A5037957365- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Ion-surface interactions and analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Smart Grid Security and Resilience
- Diamond and Carbon-based Materials Research
- Nasal Surgery and Airway Studies
- Power Systems and Renewable Energy
- Microbial Natural Products and Biosynthesis
- Power System Optimization and Stability
- Microgrid Control and Optimization
- Reproductive Biology and Fertility
- Microbial Metabolism and Applications
- Ear and Head Tumors
- Otitis Media and Relapsing Polychondritis
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Tyrosine Phosphatases
- Chemical synthesis and alkaloids
- Congenital Ear and Nasal Anomalies
- Fungal and yeast genetics research
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Real-time simulation and control systems
Toho University
2017-2025
Toho University Ohashi Medical Center
2017-2025
Toa Pharmaceutical (Japan)
2024
Jikei University School of Medicine
2020-2024
Tokyo University of Science
2006-2014
Kobe Gakuin University
2012
Nagasaki International University
2011
New Energy and Industrial Technology Development Organization
2008
National Research Center for Preventive Medicine
1995
TRW Automotive (United States)
1983
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, distinguished from other non‐eosinophilic (NECRSwNP) types. However, the pathogenesis of each remains unclear. Methods Nasal polyp tissues ECRS (ECRSwNP) NECRS patients were obtained, their comprehensive gene expression profiles investigated by microarray analysis. Bioinformatics approaches (eg, Ingenuity...
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of various endotypes, including eosinophilic CRS (eCRS), which characterized by marked infiltration and high refractory rates despite treatment. Recent findings suggest the interaction between local IgE mast cells in nasal polyps (NPs) key to eCRS pathogenesis; however, details remain unclear. This study investigated involvement MS4A2, component receptor, pathogenesis eCRS. NP tissue samples were collected from 47 patients...
Abstract Gut microbiota plays an important role in regulating brain function and adult neurogenesis. Although probiotics have recently been reported as effective against certain psychiatric disorders, the underlying mechanisms remain unclear. In particular, combination of 3 probiotic strains, Bacillus subtilis TO-A, Enterococcus faecium T-110, Clostridium butyricum hereafter referred to ProB3, has potentially alleviate symptoms patients with schizophrenia. Herein, we show that ProB3 promotes...
New alkylated hydroquinones violaceoid A (1), B (2), and C (3), an phenol D (4), a cyclohexenoid E (5) were isolated from culture broth of Aspergillus violaceofuscus Gasperini moss. The structures identified by interpretation spectroscopic data (1D 2D NMR, MS, IR). Two known compounds, the 6 eupenoxide (7), also isolated. Compound was for first time as natural product named F. Isolated compounds tested cytotoxic activity against five human cancer cell lines mouse macrophage line. Violaceoid...
BACKGROUND Pleomorphic adenoma of the salivary gland is a common benign tumor parotid gland. However, pleomorphic arising in minor glands, including nasopharynx, uncommon. This report case nasal which preoperative imaging findings were consistent with histological features gland, differs from that major CASE REPORT A 56-year-old Japanese man was referred to department otolaryngology following endoscopy performed at referral center identified right mass. The contrast-enhanced magnetic...
This paper provides an overview of strategies and the results grid-connection-related demonstrative projects New Energy Industrial Technology Development Organization (NEDO). NEDO is Japan's largest public R&D management organization for promoting development advanced industrial, environmental, new energy conservation technologies. One important objectives NEDO's solving problems that arise when distributed renewable resources are connected to power grids. These issues because output from...
The total synthesis of (+)-Sch 725680, a member the hydrogenated azaphilone family, has been accomplished. confirmed absolute configuration and biological activities natural product. A key reaction to construct core skeleton is Ti-mediated aldol reaction.
Molecular dynamics calculation was performed to simulate nano-Focused Ion Beam (FIB) processing on a Silicon surface. A combination of potential functions impacting ion and target atoms evaluated, the influence computational domain along lateral directions estimated. The (100) surface Si crystal were described by Tersoff potential. Ion-beam source represented Ga ions, where optimal chosen comparing Lennard-Jones, Tersoff, ZBL (Ziegler, Biersack Littmark) potentials. initial velocity...
TRA98 is a testis-specific nuclear protein, but its biological role unclear.We analyzed the localization of in developing spermatogenic cells using immunofluorescence (IF) and immunoelectron microscopy (IEM).TRA98 was localized exclusively to nuclei.In spermatocytes, IF staining associated with certain sub-nuclear structures show reticular pattern; XY body strongly stained.In spermatids, both punctate patterns were observed.In late decreased as cell differentiation proceeded.However,...
Saccharomyces cerevisiae Stm1 protein (273 amino acids) is a purine motif triplex DNA-binding protein. Here, to examine the location of domain protein, we analyzed interaction between and series truncated proteins by electrophoretic mobility shift assay. Stm(1-113) (amino acids 1-113) was able bind with triplex. Smaller regions in Stm(1-113), Stm(1-54) 1-54) Stm(55-113) 55-113), were unable Although has ability triplex, it duplex. We conclude that minimal specifically
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic and sinonasal inflammatory disease. Recently, resident memory B (BRM) cells have been identified in the lungs, although not mucosa. Our aim was to characterize B-cell phenotypes regard patients CRSwNP identify BRM both normal sinonosal mucosa samples from CRSwNP. CD19+ were isolated analyzed using flow cytometry immunohistochemistry. Although found mucosa, their numbers frequencies tended be limited. These findings confirmed on...
Central venous catheter insertion and cancer represent some of the important predisposing factors for deep thrombosis (DVT). DVT usually develops in lower extremities, upper extremities is uncommon. Early diagnosis treatment are importance, because it a precursor complications such as pulmonary embolism postthrombotic syndrome. A 47-year-old woman visited our department with painful swelling on left side her neck. Initial examination revealed region extending from neck to shoulder without...
The investment in both time and man- effort that utilities make supplying an initial data base, testing, debugging, commissioning a state estimator is quite large. This paper addresses the modelling, base definition tuning associated with estimator, as well problems encountered during field installation. proper sequence of steps necessary for checkout presented.
アレルギー性真菌性鼻副鼻腔炎 (allergic fungal rhinosinusitis; AFRS) は, 吸入した真菌が副鼻腔に定着したのちに非浸潤性に増殖し, 真菌に対するⅠ型・Ⅲ型アレルギー反応や T 細胞応答などにより病態が形成されると考えられている. 今回われわれは, 当院で内視鏡下鼻内副鼻腔手術 (endoscopic sinus surgery; ESS) を施行した834例のうち, AFRS と確定診断した9例に対し, 後方視的観察研究を行った.