Japanese patients with chronic rhinosinusitis nasal polyps (CRSwNP), differing from European and U.S. patients, are suggested to show two distinct phenotypes: Th2-polarized Th1-shifted immunity. The purpose of this study was conduct clinical subgrouping CRSwNP based on inflammatory cell infiltration, which evaluated supported by backgrounds immunological characteristics.A cross-sectional study.One hundred thirty were classified the infiltration eosinophils neutrophils in polyps....

Abstract Objectives/Hypothesis: Eosinophilic chronic rhinosinusitis (CRS) is characterized by the accumulation of numerous eosinophils in sinus mucosa and nasal polyps, which are frequently difficult to control, even with surgery. The present study was designed evaluate expression localization eotaxins, well known be potent selective chemoattractants for CRS. Study Design: Randomized study. Methods: patients were classified into eosinophilic noneosinophilic groups. Histopathological profiles...

OBJECTIVE: To evaluate the effects of diabetes on cochlear elements in human beings. STUDY DESIGN AND SETTING: Twenty‐six temporal bones (mean age, 37.5 years) with type 1 and 30 age‐matched controls were examined by light microscopy. We compared findings vessels, hair cells, spiral ganglion lateral walls. RESULTS: In diabetics, walls vessels basilar membrane ( P < 0.001) stria vascularis 0.01) significantly thicker all turns loss outer cells (OHCs) was greater lower basal turn 0.01)....

Interleukin (IL)-17A is a highly inflammatory cytokine with robust effect on stromal cells in many tissues. Although IL-17A known to be associated lung disorders by triggering an accumulation of neutrophils, the upper airway still uncertain. The expression and its role were investigated nasal polyps chronic rhinosinusitis asthma.IL-17A was detected immunohistochemistry quantitative real-time RT-PCR. cellular source examined double staining EG2, CD4 neutrophil elastase. tissue remodeling...

Retropharyngeal infiltrative intramuscular lipomas are rare, and only 2 cases have been reported. Surgical resection is technically challenging owing to anatomical constraints, with no established optimal approach. Furthermore, the risk of recurrence high. Herein, we report a novel, minimally invasive, effective surgical approach for retropharyngeal lipoma. A 75-year-old woman presented snoring as chief complaint. Magnetic resonance imaging revealed 52 × 38 mm lipoma in space infiltration...

Previous reports on aging of human cochlea included subjects with ear diseases or ototoxic drugs. We studied spiral ganglion cells, hair and lateral wall from without disease drugs.This study 39 temporal bones 24 aged 1 day to 86 years. assessed standard cytocochleograms, mean loss fibrocytes in ligament, areas stria vascularis.Losses outer cells were significantly greater children, adults, the elderly compared infants. Spiral cell was adults infants children. Areas vascularis larger than...

Malignant cells show increased uptake, which is considered to be facilitated by glucose transporters (GLUTs). Increased GLUT-1 expression has been reported in many human cancers. We hypothesized that a oral squamous cell carcinoma, characterized high frequency of lymph node metastasis, distant metastasis or local recurrences, was associated with overexpression invasion front.GLUT-1 immunostaining front studied on 24 carcinomas, and revealed the correlation clinical characteristics.The...

To disclose the histopathologic findings in contralateral temporal bone unilateral Ménière's disease.Several functional studies reported abnormal ears patients with disease.This study involved quantitative analysis, including number of spiral ganglion cells, loss cochlear hair area stria vascularis, and density fibrocytes ligament. It included 14 bones from 7 subjects bilateral disease, 30 15 17 age-matched normal control 12 subjects.The mean cells disease was 17,376.0 significantly lower...

There are a number of genetic diseases that affect the cochlea early in life, which require normal gene transfer developmental stage to prevent deafness. The delivery adenovirus (AdV) and adeno-associated virus (AAV) was investigated elucidate efficiency cellular specificity transgene expression neonatal mouse cochlea. extent AdV transfection is comparable obtained with adult mice. AAV-directed after injection into scala media through cochleostomy showed supporting cells, inner hair cells...

Recently, some researchers have reported that macrophages and neutrophils were related to severe asthma. Mucus hypersecretion persistent airway inflammation result from increased expression of mucin gene (MUC5AC). Eosinophilic chronic rhinosinusitis (ECRS) is considered as intractable rhinosinusitis. From the viewpoint “one way one disease,” we examined whether ECRS associated with infiltrating macrophages, neutrophils, their promotive factors, MUC5AC. We 21 nasal polyps CRS. Each specimen...

The present study was designed to elucidate the immunoreactivity and protein level of IL-17 in human cholesteatomas.The expression localization receptor activator nuclear factor κB ligand (RANKL) were examined by immunohistochemistry tissue specimens collected from 24 patients with cholesteatomas. cellular sources assessed double staining CD4. determined using an enzyme-linked immunosorbent assay. degree bone destruction compared immunoreactivity.IL-17 detected inflammatory cells granulation...

Conclusion: Our results demonstrate for the first time a potentially enhanced basal secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin (IL)-17A-stimulated IL-6 from nasal polyp fibroblasts, eosinophilic remarkable up-regulation IL-9 granulocyte colony-stimulating factor (G-CSF) fibroblasts by IL-17A stimulation. Objectives: The fibroblast, one main cell types making up polyps, is thought to be target various cytokines. Methods: Subcultured were established human biopsy...

We experienced a case of an elongated styloid process that was 8 cm in length. The patient 68-year-old Japanese man with frequent episodes left-sided throat pain for 10 years. could be diagnosed by 3D-computed tomography (left and right length: 7.8 8.0 cm, respectively) successfully treated surgery, since the anatomic relationships fully visualized. Surgical methods shortening involve intraoral or external approach. approach to involves trans-cervical parapharyngeal space, which enables...

Methicillin-resistant Staphylococcus aureus (MRSA) otorrhea has become an increasing problem with regard to infection through the tympanic membrane perforation and postsurgical infection. In particular, dry ear, at preoperative stage, is considered be a crucial factor in surgery. We evaluated how control MRSA before after ear surgery.Twenty-six patients having were enrolled present study randomly divided into 2 groups, namely, mupirocin ointment therapy for 16 ofloxacin drops 10 patients....

<b><i>Background:</i></b> Eosinophils generate large amounts of oxidant species. The eosinophil-dominant type chronic rhinosinusitis (CRS) with nasal polyps is related to more extensive disease and a decreased likelihood surgical success. Superoxide dismutase (SOD) the first-line only antioxidant enzyme that converts superoxide hydrogen peroxide. <b><i>Methods:</i></b> patients CRS were divided into eosinophilic noneosinophilic groups....

Introduction Eosinophilic chronic rhinosinusitis (ECRS) is characterized by an eosinophilic inflammation driven Th2-type cytokines. Glucocorticosteroids are the most common first-line treatment for ECRS with nasal polyps. Objective We have evaluated long-term double-dose intranasal corticosteroids in refractory polyps resistant to conventional dose and assessed risk of adverse systemic effects Methods Sixteen subjects were enrolled this study. All had after endoscopic sinus surgery that...

Conclusion: We found no significant differences in the bacterial features of maxillary sinuses between eosinophilic and neutrophilic chronic rhinosinusitis (CRS) with nasal polyps. Objectives: Since CRS is often influenced by a predisposition to infection, likely be developed allergic antigens, microbiology two pathologies can expected. The present study was designed investigate findings from sinus CRS. Methods: Seventy patients polyps were divided into types based on histopathological...

Orbital apex syndrome is commonly been thought to have a poor prognosis. Many cases of this reported be caused by paranasal sinus mycosis. We encountered very rare case (60-year-old woman) sinusitis with orbital due Pseudomonas aeruginosa infection. She had received insulin and dialysis for diabtes diabetic nephropathy, moreover anticoagulants after heart by-pass surgery. underwent endoscopic operation was treated antibiotics, but her loss left vision did not improve. Recently, were...

Distortion product otoacoustic emissions (DPOAEs) have been used to examine the development of hearing in rat and gerbil. However, no reports DPOAE measurement from onset mice are available. Commercially-available components were assembled adapted provide a suitable probe microphone sound delivery system for measuring developing C57BL/6J mice. Furthermore, data compared with findings auditory brainstem response (ABR). DPOAEs obtained at 8 kHz 11 days after birth, 20 12 days, 30 13 days....