A5005886374- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Trauma and Emergency Care Studies
- Neurological Complications and Syndromes
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Streptococcal Infections and Treatments
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
- Pregnancy-related medical research
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Trauma Management and Diagnosis
- COVID-19 Impact on Reproduction
- Reproductive Health and Technologies
- Blood Coagulation and Thrombosis Mechanisms
Mie University
2015-2024
Tsu City College
2015-2023
Seirei Sakura Citizen Hospital
2017-2023
Mie University Hospital
2016-2023
Miyagi University of Education
2023
National Cerebral and Cardiovascular Center
2013-2020
Geospatial Information Authority of Japan
2019-2020
Kyorin University Hospital
2019-2020
Tokyo University of Pharmacy and Life Sciences
2011-2020
Fukushima Medical University Hospital
2019
To clarify the problems related to maternal deaths in Japan, including diseases themselves, causes, treatments and hospital or regional systems.Descriptive study.Maternal death registration system established by Japan Association of Obstetricians Gynecologists (JAOG).Women who died during pregnancy within a year after delivery, from 2010 2014, throughout (N=213).The preventability each death.Maternal were frequently caused obstetric haemorrhage (23%), brain disease (16%), amniotic fluid...
Background:The effects of β-adrenergic blockers on the fetus are not well understood. We analyzed maternal and neonatal outcomes blocker treatment during pregnancy to identify risk fetal growth restriction (FGR).
Abstract This descriptive study was based on the maternal death registration system established by Japan Association of Obstetricians and Gynecologists Maternal Death Exploratory Committee (JMDEC). 361 women died during pregnancy or within 42 days after delivery between January 2010 June 2017 throughout were analysed, in order to investigate trend deaths related obstetric medical practice. Reports consistent, ranging from 45 cases 44 2017. Among all deaths, frequency due haemorrhage ranged...
Perinatal care in Japan has progressed rapidly recent decades, remarkably reducing maternal, perinatal and neonatal mortality rates. This is attributable not only to the sustained efforts dedication of past obstetricians midwives, but also collective results achieved by Society Obstetrics Gynecology healthcare administration, including research on advanced medical care, education, improvements establishing centers. Although maternal rate was steady decline until 2007 (3.1/100 000 births), it...
Abstract BACKGROUND We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE FGR pregnant mice as our experimental model. METHODS C57BL/6 were divided into 2 groups 11 days postcoitum (d.p.c.). A control group dams (C dam) received 0.5% carboxymethylcellulose (CMC). L-NAME-treated 1 mg/ml L-NAME dissolved CMC. The subgroups 13...
We postulated a 'kinin-tensin system' in which angiotensin II (Ang II) is cleaved by one or more serine protease independent of renin converting enzyme (ACE). The aim was to determine whether this alternative Ang II-forming pathway proteases participates the rise plasma levels during exercise humans.The study consisted two double-blind crossover experiments. experiment 1 six healthy volunteers who had been taking either placebo (group P) ACE inhibitor captopril (150 mg/day for 3 days; group...
Pulmonary hypertension (PH), caused by elevated pulmonary vascular resistance, leads to right heart failure and ultimately death. Vitamin D deficiency can predispose individuals left ventricular dysfunction; however, it remains unknown how serum vitamin level is related PH (RV) dysfunction.Serum 25-hydroxyvitamin [25(OH)D] levels were assessed in patients for an association with disease severity. To examine whether supplementation could prevent the development of remodeling RV dysfunction...
Abstract Aim We designed a safety and dose‐finding trial of tadalafil administered for fetal growth restriction (FGR). Methods Three cases were initially commenced on 10 mg/day monitored major adverse events. Should event be observed in one or more the three cases, an examination into its relation with would conducted by evaluation committee. If these new exhibited same event, stopped completely. there no harmful side‐effects, extended to at 20 mg/day, protocol continue as 10‐mg/day dose....
Background:The aim of this study was to clarify the clinical features maternal death due stroke associated with pregnancy-induced hypertension (PIH) in Japan.Methods and Results:Reported deaths occurring between 2010 2012 throughout Japan were analyzed by Maternal Death Exploratory Committee. Among a total 154 reports death, those (n=12) or without (n=13) PIH compared. Cerebral occurred more frequently third trimester during second stage labor PIH, whereas it at any time point not involving...
The influence of the physiological circulatory changes during pregnancy on hypertrophic cardiomyopathy (HCM) is unclear. There have been no comprehensive studies pregnant women with HCM in Japanese population.A total 27 pregnancies (23 HCM) were retrospectively reviewed. A 18 cardiovascular events occurred 13 (48%), and these (76%) related to arrhythmia. tended occur early stage (≈30 gestational weeks) or postpartum. arrhythmia mainly at approximately 30 weeks. Four terminated because...
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with long half-life, high selectivity, and rapid onset of action. Because the safety using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been problem worldwide, this paper primarily focuses on assessments performed in Treatment Fetuses Early-Onset Growth Restriction (TADAFER) II population. Neonatal maternal adverse events were analyzed, addition to fetal, neonatal, infant death cases, six months after...
The aim of this retrospective study was to assess tadalafil treatment in pregnant women with fetal growth restriction (FGR) terms maternal and perinatal outcomes.We retrospectively analyzed 11 Japanese singleton FGR who received along conventional management for at Mie University Hospital from July 2015 February 2016 (tadalafil group). These were matched age, parity, gestational estimated weight enrollment 14 only the 2014 (conventional performed according guidelines obstetric practice...
Abstract We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor dilates the maternal blood sinuses placenta, thereby facilitating of fetus. The purpose this study was to investigate effects treatment for PE and FGR on developing brain offspring using an L-NAME-induced mouse model FGR. A control group dams received...
This study aimed to clarify the relationship between maternal mortality and advanced age in Japan provide useful information for future perinatal management. Maternal death rates by group were investigated all deaths an 11-year period, from 2010 2021. among those aged ≥ 40 years examined detail determine cause, number of cause was calculated. The causes onset most common also investigated. 0.8 (95% confidence interval [CI] 0.3-4.7) < 20 years, 2.6 CI 1.7-3.8) 20-24 2.9 2.3-3.6) 25-29 3.9...
Abstract Aim In Japan, unlike Western countries, tocolytic agents are administered in long‐term protocols to treat threatened preterm labor. Evaluating the side effects of this practice is crucial. We examined whether ritodrine hydrochloride had been cases maternal death, aiming investigate any relationship between administration and death. Methods This retrospective cohort study used reports deaths from multiple institutions Japan 2010 2020. Data on reported were retrospectively analyzed,...
Twenty-one patients with essential hypertension were treated aerobic (lactate threshold) exercise (n = 21) and the change in blood pressure was compared that a non-exercising hypertensive control group 10). After 10 weeks of therapy significantly reduced, from 154 ± 3/100 2 to 141 3/93 3 mmHg, there significant reduction plasma volume, cardiac index noradrenaline whereas no changes non-exercise group. Responders (10 mmHg or more fall mean pressure) had higher index, serum Na: K ratio lower...
Abstract Aims The incidence of T akayasu arteritis during child‐bearing years is relatively high. management pregnancies in patients with this disease great importance clinical obstetrics. Here we analyzed women Takayasu and without complications. Material Methods We retrospectively identified 27 20 seen between 1983 2005 at the National Cardiovascular Center, O saka, J apan. incidences obstetric events, steroid dose increase pregnancy, cardiovascular events were compared group I (no...
Background:The aim of the present work was to understand current circumstances maternal-death-related venous thromboembolism (MD-VTE) in Japan. We retrospectively investigated characteristics cases MD-VTE, and compared past rates occurrence.Methods Results:We examined Japanese data for MD-VTE 2010–2013, it with that from 1991–1992. occurred 17 women 1991–1992, 13 2010–2013. The maternal mortality ratio 0.7 per 100,000 1991–1992 0.4 Both rate 2010–2013 deceased significantly (P<0.05)....