A5056637574- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Neurological Complications and Syndromes
- Gestational Diabetes Research and Management
- Bone Metabolism and Diseases
- Cytomegalovirus and herpesvirus research
- Maternal and Perinatal Health Interventions
- Cardiac Structural Anomalies and Repair
- Blood Coagulation and Thrombosis Mechanisms
- Trauma and Emergency Care Studies
- Neonatal and Maternal Infections
- Pelvic floor disorders treatments
- Bone health and treatments
- Streptococcal Infections and Treatments
- Bone and Dental Protein Studies
- Congenital Diaphragmatic Hernia Studies
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrhythmias and Treatments
- Cancer, Hypoxia, and Metabolism
Mie University
1993-2024
Mie University Hospital
2018-2023
Chiba University
2023
Weatherford College
2023
Miyagi University of Education
2023
University of Fukui
2023
Kurume University
1998-2019
Tsu City College
2019
National Cerebral and Cardiovascular Center
1993-2018
Meikai University
1991-1995
Although the action of insulin-like growth factor-I (IGF-I) on bone formation has been extensively investigated, effect factor resorption is little known. We first examined IGF-I by preexistent osteoclasts using unfractionated cells cultured dentin slices. had a dose-related stimulating osteoclasts, whereas IGF-II did not. When was added to cultures after degenerated slices, increased number osteoclastic multinucleate (MNCs) with tartrate-resistant acid phosphatase activity. Moreover,...
Abstract Previously, we have shown that the adipocyte-specific nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously developed hepatic lesions are similar to those human nonalcoholic steatohepatitis (NASH) with a concomitant elevation plasma TNF-α. In this study, analyzed role TNF-α in progression fatty liver disease (NAFLD). We established Tnf knockout nSREBP-1c mouse line. Glucose tolerance and histology were examined at age 20 weeks. The...
Background:The effects of β-adrenergic blockers on the fetus are not well understood. We analyzed maternal and neonatal outcomes blocker treatment during pregnancy to identify risk fetal growth restriction (FGR).
Abstract BACKGROUND We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE FGR pregnant mice as our experimental model. METHODS C57BL/6 were divided into 2 groups 11 days postcoitum (d.p.c.). A control group dams (C dam) received 0.5% carboxymethylcellulose (CMC). L-NAME-treated 1 mg/ml L-NAME dissolved CMC. The subgroups 13...
The influence of the physiological circulatory changes during pregnancy on hypertrophic cardiomyopathy (HCM) is unclear. There have been no comprehensive studies pregnant women with HCM in Japanese population.A total 27 pregnancies (23 HCM) were retrospectively reviewed. A 18 cardiovascular events occurred 13 (48%), and these (76%) related to arrhythmia. tended occur early stage (≈30 gestational weeks) or postpartum. arrhythmia mainly at approximately 30 weeks. Four terminated because...
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with long half-life, high selectivity, and rapid onset of action. Because the safety using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been problem worldwide, this paper primarily focuses on assessments performed in Treatment Fetuses Early-Onset Growth Restriction (TADAFER) II population. Neonatal maternal adverse events were analyzed, addition to fetal, neonatal, infant death cases, six months after...
Abstract We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor dilates the maternal blood sinuses placenta, thereby facilitating of fetus. The purpose this study was to investigate effects treatment for PE and FGR on developing brain offspring using an L-NAME-induced mouse model FGR. A control group dams received...
This study aimed to clarify the relationship between maternal mortality and advanced age in Japan provide useful information for future perinatal management. Maternal death rates by group were investigated all deaths an 11-year period, from 2010 2021. among those aged ≥ 40 years examined detail determine cause, number of cause was calculated. The causes onset most common also investigated. 0.8 (95% confidence interval [CI] 0.3-4.7) < 20 years, 2.6 CI 1.7-3.8) 20-24 2.9 2.3-3.6) 25-29 3.9...
Abstract Aims The incidence of T akayasu arteritis during child‐bearing years is relatively high. management pregnancies in patients with this disease great importance clinical obstetrics. Here we analyzed women Takayasu and without complications. Material Methods We retrospectively identified 27 20 seen between 1983 2005 at the National Cardiovascular Center, O saka, J apan. incidences obstetric events, steroid dose increase pregnancy, cardiovascular events were compared group I (no...
Objective: The number of stroke-related maternal deaths is increasing in Japan. We investigated methods to reduce death from stroke.Methods: analyzed Japan reported the Committee Ministry Health, Labor, and Welfare 2010 2014 inclusive.Results: A total 35 cases were identified. median age was years (range 22–45) incidence stoke women ≥40 seven-fold higher than <34. Etiologies pregnancy induced hypertension 16, subarachnoid hemorrhage seven, cerebral infarction three, arteriovenous...
We studied the efficacy of sitagliptin in type 2 diabetic patients our outpatient clinics. Since December 2009, 164 have been treated by for their management diabetes. HbA1c decreased 0.8% all without any change mean body weight after 3 months. However, actually did not decrease 30 patients, and more than half showed gain to some extent. Patients were classified according reduction analyzed based on this category. Baseline characters such as age, gender, duration diabetes, BMI, concomitantly...
To make recommendations for saving mothers' lives, issues related to maternal deaths including diseases, causes, treatments, and hospital regional systems are analyzed by the Maternal Death Exploratory Committee in Japan. In this report, we present ten clinical important based on analysis of between 2010 2014
To assess the effect of adiponectin on circadian rhythm disturbances associated with metabolic syndrome, we generated a KK/Ta mouse line expressing human transgene in liver. Locomotor activity control C57BL/6 mice was highest during beginning dark period and low light period. Under constant darkness, length locomotor slightly shorter than 24 h. In peak blunted significant observed Furthermore, showed average free-running when compared mice. However, transgenic expression liver significantly...
Itai-itai disease is caused by environmental cadmium (Cd) pollution in the Jinzu River basin Japan. To reduce Cd contamination of rice, soil restoration paddy fields was carried out. We evaluated effect on health status residents former Cd-polluted area.Participants were 1,030 men and 944 women who lived area rice paddies. First morning urine collected urinary Cd, β2-microglobulin (β2MG), N-acetyl-β-D-glucosaminidase (NAG) levels measured. Associations among age, years residence before after...
Cesarean section is commonly selected in pregnancy with Moyamoya disease. We consider vaginal delivery epidural anesthesia a viable alternative such cases.Mode of and outcomes were examined 27 pregnancies 19 women disease treated at the Department Perinatology, National Cardiovascular Center, Japan, from 1983 to 2013. Of these pregnancies, 20 delivered vaginally anesthesia. The cerebral circulation, mode delivery, maternal outcome (presence symptoms due intrapartum) neonatal (gestational...
Background: Consensus has not been reached about the anticoagulant therapy to be used during pregnancy after mechanical valve replacement. Warfarin is a fetal toxicant, so we retrospectively examined using unfractionated heparin. Methods and Results: Pregnancy replacement occurred in 25 cases between 1983 2011. Targeted heparin was administered 9 pregnancies, which were divided into 3 groups: Group I received subcutaneous administration of APTT measured twice weekly; II by constant rate...
Abstract Aim To clarify the perinatal outcomes in pregnancy complicated with intracranial arteriovenous malformation (i‐AVM). Methods A retrospective study was performed 36 pregnancies by i‐AVM from 1981 to 2013 at one institution. Results In total, 6 women miscarried, and 30 had live births. The median (range) gestational age delivery 38 (24–40) weeks; 11 cases experienced initial rupture during (first, second third trimester: 18%, 64% respectively). At onset, 4 a Glasgow Coma Scale ≤10, 10...
Unlike Europe and the United States, Japan has seen numerous maternal deaths from hemorrhagic strokes related to hypertensive disorders of pregnancy (HDP). This study retrospectively analyzed associated with HDP-related stroke in determine number that may have been prevented blood pressure control during pregnancy.This included cases. The proportion patients without proteinuria whose exceeded 140/90 mmHg between 14+0 33+6 weeks gestation were determined. Lastly, application tight...
Aims/Hypothesis The aim of this study was to elucidate the mechanism by which severe hypoglycemia accelerates vascular complications. Furthermore, we assessed possible protective effect ketone bodies against endothelial cell damage caused glucose deficiency. Methods Human umbilical vein cells (HUVECs) were cultured at a level either 0.56 or 5.6 mmol/L with without 3-hydroxybutyrate (3-HB) supplementation. Cell viability CCK-8 assay and lactate dehydrogenase (LDH) release assay. activity...