A5100414322- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biomarkers in Disease Mechanisms
- Head and Neck Cancer Studies
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
Yanbian University
2019-2023
State Ethnic Affairs Commission
2022
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
The Affiliated Hospital to Changchun University of Chinese Medicine
2020
<abstract> <sec><title>Background</title><p>Non-chromosomal structure maintenance protein condensin complex I subunit H (NCAPH) has been reported to play a regulatory role in variety of cancers and is associated with tumor poor prognosis. This study aims explore the potential NCAPH view providing insights on pathologic mechanisms.</p> </sec> <sec><title>Methods</title><p>The expression different tumors was explored by The...
Abstract Background T lymphoma invasion and metastasis 1 (Tiam1) is a tumor related gene that specifically activates Rho-like GTPases Rac1 plays critical role in the progression of various malignancies. Glycolysis an important cancer progression, it crucial for supplying energy producing metabolic end products, which can maintain survival cells. As yet, however, mechanism Tiam1 glycolysis reprogramming pancreatic (PC) remains to be clarified. Here, we investigated functional PC cell...
Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are the major enzymatic source of reactive oxygen species (ROS).NOX2 and NOX4 expressed in heart but its role hypoxia-induced atrial natriuretic peptide (ANP) secretion is unclear.This study investigated effect NOX on ANP induced by hypoxia isolated beating rat atria.The results showed that significantly upregulated not NOX2 expression, which was completely abolished endothelin-1 (ET-1) type A B receptor antagonists BQ123 (0.3 M)...
<title>Abstract</title> Accurate prognosis prediction of head and neck squamous cell carcinoma (HNSCC) is vital for guiding clinical decision-making. DNA methylation (DNAm) plays important roles in the regulation gene expression abnormal DNAm a hallmark cancers. This study aimed to develop prognostic model HNSCC based on changes that can regulate expression. Based The Cancer Genome Atlas dataset, we constructed novel four-CpG (cg02409878, cg01984743, cg23867673, cg01995815) risk score...
Background : To explore expression and immune infiltration of SPARC/osteonectin, cwcv, maze-like domains proteoglycan 1 (SPOCK1) in Head Neck squamous cell carcinoma. Methods A total 107 HNSC patients’ tissues 15 adjacent normal were collected this study. Co-expressed gene set enrichment analysis was detected using STRING Linked Omics. Immune related to SPOCK1 analyzed via TIMER. Results The positive rate significantly higher than that by immunohistochemical staining ( p < 0.01). a...
Abstract Background Accurate prognostic prediction in Head and neck squamous cell carcinoma (HNSCC) patients remains challenging owing to its heterogeneity intra- inter-pathological variability. Numerous models for HNSCC have been developed; however, they limited performances. Moreover, DNA methylation (DNAm) plays important roles the regulation of gene expression abnormal DNAm is a hallmark cancers. Methods Based on The Cancer Genome Atlas (TCGA) dataset, we first identified CpGs associated...
Abstract Background: Our previous studies found that polymorphism of activating transcription factor 6 (ATF6) was associated with susceptibility to hepatocellular carcinoma (HCC), and ATF6 promoted HCC progression. So genes down-regulated by might play a tumor suppressing role. In present study, we aimed identify downstream ATF6, clarified its role in Methods: To determine the on gene expression, qRT-PCR western blot were performed cells liver specifically Atf6 -knocked out mice. Tumor...