The aim of this study is to conduct a thorough evaluation the association between Benzophenone-3 (BP-3) exposure and OA, offering critical insights into underlying mechanisms involved. National Health Nutrition Examination Survey (NHANES) database was utilized investigate correlation BP-3 osteoarthritis. Proteomic sequencing from clinical sample PharmMapper online tool were employed predict biological target BP-3. Cellular molecular assays transfection studies performed verify prediction...

Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and α-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) 90 cirrhosis. The mean concentration PIVKAII HCC was higher than that cirrhotic patients. A total 53.3% (64 out 120) had above 40 mAU ml−1. However, only 13 cirrhosis PIVKA levels. Of 32 small patients, (40.6%) values An increased AFP (i.e. 20 ng ml−1)...

Glucocorticoids (GCs) are the mainstay treatment of myasthenia gravis (MG). However, wide inter-individual variability exists in response to GCs.A Chinese cohort 257 MG patients treated with GCs was evaluated for association between 19 single nucleotide polymorphisms GR gene and clinical initial 3 month GC therapy. A quantitative score decreasing by ≥3 units or becoming zero defined as sensitivity GCs.The rs17209237* G allele less frequent insensitive group compared sensitive [P = 0.013,...

To compare the visual and refractive outcomes after laser-assisted in situ keratomileusis (LASIK) surgery for correction of myopia or myopic astigmatism using a six-dimensional Amaris excimer laser.In this retrospective cohort study, we enrolled 47 eyes 28 patients (age: 19-36 years) with astigmatism. We used Custom Ablation Manager protocol performed ablations SCHWIND AMARIS system. LASIK flaps were cut an iFS Advanced Femtosecond Laser. Mean static (SCC) dynamic cyclotorsion (DCC)...

Abstract Background Uveal melanoma (UVM) is the most common primary ocular malignancy, with a wide range of symptoms and outcomes. The programmed cell death (PCD) plays an important role in tumor development, diagnosis, prognosis. There still no research on relationship between PCD-related genes UVM. A novel PCD-associated prognostic model urgently needed to improve treatment strategies. Objective We aim screen signature investigate its proliferation ability apoptosis UVM cells. Methods...

Osteoarthritis (OA) is a chronic joint disease affecting millions of adults worldwide, characterized by degeneration articular cartilage. Many environmental risk factors contribute to OA development. Benzophenone-3 (BP-3), commonly used ultraviolet filter in personal care products, has been positively associated with risk. However, it remains unclear whether and how BP-3 induces toxic effects on chondrocytes promote This study aims investigate the damage at environmentally relevant...

Abstract To investigate wavefront aberrations in the entire eye and internal optics (lens) retinal image qualities according to different lenticular opacity types densities. Forty-one eyes with nuclear cataract, 33 cortical 29 posterior subcapsular cataract were examined. In each group, quality measured using a raytracing aberrometer. Eyes cataracts showed significantly higher coma-like compared other two groups both optic ( P = 0.012 0.007, respectively). had lower spherical-like than <...

To explore the offset distribution of pupillary centres, between pupil centre and coaxially sighted corneal light reflex (P-Dist) their correlation in femtosecond laser combined with excimer situ keratomileusis.Randomly selected 194 patients (398 eyes) who underwent femtosecond-assisted keratomileusis preoperative use WaveLight Allegro Topolyzer Corneal Topography (WaveLight Laser Technologies AG, Erlangen, Germany) to measure size position. The P-Dist was recorded by X Y axis eyeball...

Purpose To report a case of neurogenic dry eye (NDE) that developed after intravitreal ranibizumab injection (IVR). Case A 71-year-old woman had history cataract phacoemulsification and intraocular lens (IOL) implantation, Nd:YAG laser posterior capsulotomy femtosecond laser-assisted in situ keratomileusis (FS-LASIK). Aneurysmal dilatation the inferior temporal retina was found left fundus, which diagnosed as retinal aneurysm, administered. Dry first injection. After second injection,...

To investigate the differences between dominant and nondominant eyes in a predominantly young patient population by analyzing angle kappa, pupil size, center position eyes.A total of 126 college students (252 eyes) with myopia who underwent femtosecond laser-combined LASIK were randomly selected. Ocular dominance was determined using hole-in-card test. The WaveLight Allegro Topolyzer (WaveLight Laser Technologies AG, Erlangen, Germany) used to measure size position. offset coaxially sighted...

To analyze the distribution of offset between pupil center and coaxially sighted corneal light reflex (P-Dist), effects 50% 100% angle kappa adjustments on refractive visual quality in patients with moderate myopia were investigated. A randomly selected 254 (254 eyes) who underwent femtosecond laser-combined LASIK examined. During operation, P-Dist was recorded by x- y-axis eyeball-tracking adjustment program WaveLight Eagle Vision EX500 excimer laser system. Preoperatively 3 months...

To investigate the differences between dominant and nondominant eyes in femtosecond laser-assisted laser situ keratomileusis (FS-LASIK) with 50% angle kappa compensation on diopter visual quality.University hospital.Retrospective clinical study.109 patients (218 eyes, 100%) myopia who underwent FS-LASIK were randomly selected. The preoperative pupil size, center position, offset coaxially sighted corneal light reflex ( P-Dist ) of was recorded. In postoperative 6 months, an iTrace wavefront...

Presbyopia refers to a phenomenon in which the ability of eye accommodate is insufficient meet daily demand for proximity due age. In modern society, more and patients over 40 years old want solve visual problems caused by presbyopia refractive errors, poses new challenges clinical laser corneal surgery, variety combined correction technologies programs have emerged. However, whether surgery with technology could treat deserves attention. Based on mechanism various techniques, this article...

A 5-year-old female patient, presented with"night blindness and poor hearing for 1 year"whose first diagnosis was Usher syndrome due to retinitis pigmentosa accompanied by sensorineural deafness. Compound heterozygous variants (c.5G>A, p.W2*/c.3022C>T, p.P1008S) of PEX1, the causative gene Zellweger spectrum disorder confirmed targeted exome sequencing analysis. Permanent tooth enamel dysplasia, nail leukoplakia, biochemical abnormalities peroxisome which is consistent with mild were found...

Objective: To evaluate long-term clinical outcomes of consecutive patients treated with coronary artery bypass grafting (CABG) and percutaneous intervention(PCI) drug-eluting stents(DES) for ostial/shaft lesions in unprotected left main artery(ULMCA). Method: A total 259 isolated ostial/midshaft were enrolled consecutively who received DES implantation or underwent CABG between January 2003 July 2009 Beijing Anzhen Hospital. The endpoints the study death, repeat revascularization, myocardial...

Background The incidence of dry eye is gradually increasing, and the aging population one factors. Researches showed that change tear film stability leads to shift corneal refractive power, which probably affects measurement intraocular lens (IOL) power. The influence on calculation IOL power worth paying close attention. Objective This study was investigate accuracy in age-related cataractous patients. Methods A non-randomized controlled clinical performed. Two hundred sixteen...

Abstract Rationale: Breast carcinoma is the most common primary source of choroidal metastasis (CM). In present case, esophageal cancer was tumour, brain occurred, and CM occurred later in left eye with 2 retinal detachments, which very rare. Patient concerns: A 62-year-old man complained a sudden decrease visual acuity consisting small shadow front his sensation covered vision after 1 cycle systemic chemotherapy radiotherapy for resected metastasis. Fundus examination revealed exudative...

In order to optimize the parameters of dielectric barrier-discharge plasmas, emission spectrum second transition line oxygen and nitrogen under normal temperature pressure was measured with a grating spectrometer. The results show that intensity plasma increases voltage, best frequency range generate is 39—41kHz. Meanwhile, introduction helium gas high extent. combination theoretical analysis, feasibility spectral method in study barrier discharge verified.

Objective: To investigate the association between plasma levels of 20 amino acids and risk diabetes in middle-aged elderly population. Methods: This study was a part Chinese multi-provincial cohort conducted communities Shougang. In 2007 2012, population investigated for other factors. Blood samples collected from 475 people were tested various acid by liquid chromatography-tandem mass spectrometry. A multivariate logistic regression analysis used to analyze risk. Results: The age selected...