A5102795947- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Heat shock proteins research
- Insect and Pesticide Research
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Calcium signaling and nucleotide metabolism
- Biological and pharmacological studies of plants
- Kruppel-like factors research
- RNA modifications and cancer
- Biochemical and Molecular Research
- PARP inhibition in cancer therapy
- Enzyme Structure and Function
- Plant and animal studies
- Genetic factors in colorectal cancer
- Connective Tissue Growth Factor Research
- Cancer Genomics and Diagnostics
- FOXO transcription factor regulation
- Lung Cancer Research Studies
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
Northeast Agricultural University
2025
ETH Zurich
2021
YangPu Geriatric Hospital
2020
Huadong Hospital
2018
Fudan University
2018
First Affiliated Hospital of Hebei Medical University
2016
Shanghai Medical College of Fudan University
1998-1999
Zhongshan Hospital
1998-1999
Cancer Institute (WIA)
1998
A new human hepatocellular carcinoma (HCC) cell line with a highly metastatic potential was established from subcutaneous xenograft of model HCC in nude mice (LCI-D20) by means alternating culture vitro and growth mice. The line, designated MHCC97, has been cultivated for 18 months subcultured more than 90 passages. showed to be origin karyotype analysis. cells were either grown as compact colonies (in clusters) or monolayered sheet about 31 h population-doubling time, exhibited typical...
Despite significant advances in cancer biology research and treatment, clinical outcomes for patients with liver remain unsatisfactory. The biological molecular mechanisms underlying the bidirectional signaling between tumor cells microenvironment (TME), which promotes progression liver, to be elucidated. Fibroblasts are crucial regulators of response therapy; however, our understanding their roles remains limited. Here, we integrated single-cell RNA sequencing spatial transcriptomic data...
Resistance to epidermal growth factor receptor (EGFR) targeted monoclonal antibody therapy represents a clinical challenge in patients suffered from RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, the molecular mechanisms and key factors conferring this resistance are largely unknown. Forkhead transcription of O class 3a (FoxO3a), an important regulator cell survival, has been reported with dual functions tumor recently. In study, we found that FoxO3a was highly expressed...
Background/Aims: Non-radical primary tumour resection (PTR) of asymptomatic metastatic colorectal cancer (mCRC) can prolong survival time some patients. Patients with mutated RAS gene have worse outcome. This study aimed to investigate the impact mutations on prognosis unresectable mCRC patients who underwent PTR. Methods: A retrospective observational cohort was deduced among experienced PTR or had intact (IPT). All them tissue genotyping tested for (KRAS and NRAS) mutations. The...
Abstract Pupylation is the post-translational modification of lysine side chains with prokaryotic ubiquitin-like protein (Pup) that targets proteins for proteasomal degradation in mycobacteria and other members Actinobacteria. Pup ligase PafA depupylase Dop are two enzymes acting this pathway. Although they share close structural sequence homology indicative a common evolutionary origin, catalyze opposing reactions. Here, we report series high-resolution crystal structures different...
Inevitable gefitinib resistance is the biggest bottleneck in current treatment and mechanisms are not fully understood. Here, we observe that PFTK1 (also named CDK14) significantly enhanced NSCLC with resistance. And upregulation of negatively associated progression-free survival (PFS) patients who receive treatment. Further study suggests can critically accelerate through suppressing its promoter methylation a DNMT3B-dependent manner. Gain loss function assays demonstrate desregulation...
Objective:To research the effect of Six1,TGF-β,VEGF-C that promoting tumor lymphangiogenesis in human laryngeal carcinoma xenografts nude mice. Method:Technology RNA interference was used for silencing Six1 and TGF-β genes expression squamous cell, preparation Six1-targeting TGF-β-targeting siRNA transfecting into cell carcinoma, sieve out positive clone amplify. Preparing bearing cancer mice, mice were divided five groups, group A (untransfected),group B(empty vector), C(Six1-siRNA),group...