A5100339449- CAR-T cell therapy research
- Colorectal Cancer Screening and Detection
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Otolaryngology and Infectious Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and osteoporosis research
- Digital Mental Health Interventions
- Tuberous Sclerosis Complex Research
- Ovarian cancer diagnosis and treatment
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Colorectal Cancer Surgical Treatments
- Technology Use by Older Adults
- Nosocomial Infections in ICU
- Intraperitoneal and Appendiceal Malignancies
- Neurological Complications and Syndromes
- Cancer Risks and Factors
Cleveland Clinic
2019-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2023
Union Hospital
2023
Huazhong University of Science and Technology
2023
Qingdao University
2019-2022
Affiliated Hospital of Qingdao University
2019-2022
University of Oslo
2022
Kunming Medical University
2022
Jining First People's Hospital
2018
The First Affiliated Hospital, Sun Yat-sen University
2018
Programmed cell death 1 (PD-1) and its ligand (PD-L1) inhibitors have quickly become standard of care for patients with advanced non-small lung cancer increasing numbers other types. In this report, we discuss the clinical history, pathological evaluation, genomic findings in a patient metastatic squamous (SCC) who developed severe nivolumab-induced pneumonitis preceding durable remission after three doses nivolumab. A chemotherapy-refractory, SCC symptomatic by week 4 nivolumab treatment,...
The proliferation of the biomarker Ki67 has been extensively studied in colorectal cancer (CRC). Although numerous cut-off values have previously reported, optimal value remains unclear with previous studies providing contrasting results. present retrospective cohort study aimed to determine for CRC. levels and prognosis patients non-metastatic CRC were obtained from Electronic Health Information System a tertiary hospital Kunming City. Restricted Cubic Spline (RCS) model was used analyze...
Objective To investigate the frequency and prognostic role of human epidermal growth factor receptor 2 gene ( HER2 ) BRAF V600E mutation in Chinese patients with colorectal cancer (CRC). Methods Clinicopathological survival information from 480 stage I–III CRC were reviewed recorded. amplification was analyzed by immunohistochemistry (IHC) fluorescence situ hybridization (FISH), tested IHC Sanger sequencing. The relationship between status clinicopathological characteristics outcomes...
Olsenella uli is anaerobic or microaerophilic bacteria, commonly found in oral cavity gastrointestinal tract, which has not been reported to be associated with lower respiratory tract infection. Herein, we report the first case of infection lung.A 70-year-old male farmer no history other diseases developed a cough bloody sputum three times day without obvious causes concomitant symptoms. After period treatment empirical antibiotic, his condition did improve. The computed tomography (CT) and...
Background/Aims: Non-radical primary tumour resection (PTR) of asymptomatic metastatic colorectal cancer (mCRC) can prolong survival time some patients. Patients with mutated RAS gene have worse outcome. This study aimed to investigate the impact mutations on prognosis unresectable mCRC patients who underwent PTR. Methods: A retrospective observational cohort was deduced among experienced PTR or had intact (IPT). All them tissue genotyping tested for (KRAS and NRAS) mutations. The...
Abstract The 15th Annual Protein Engineering Summit (PEGS) organized by Cambridge Healthtech Institute was held in Boston, USA, from 8 to 12 April 2019. This report highlights the presentations Oncology Stream of this meeting with a focus on bispecific antibodies (BsAbs). A variety BsAb formats different target antigens (CD3, CTLA4, PD-1, PD-L1, EGFR, HER2, BCMA, CD19, CD20, CD38, CD123, TGFβ, PSMA, etc.) have been discussed, which T-cell engaging (anti-CD3) is most studied construct exhibit...
This study explored the value of ascites and serum CA125, CEA, CA19-9 levels DNA ploidy analysis for diagnosis peritoneal carcinomatosis (PC) in patients with gastrointestinal ovarian malignancies, which can cause may disseminate peritoneally.We measured performed an 58 PC 44 without PC.We found that a high expression level CA125 fluid was associated occurrence malignancies (P<0.001), CEA CA19- 9 were (P=0.001, P=0.002). But, these tumor marker not significantly stage (P>0.05). We similar...
Chimeric antigen receptor T cell (CAR-T) therapy has breakthrough potential for relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL). However, because of the risk neurotoxicity, trials usually exclude patients with central nervous system (CNSL) or active neurological comorbidities (NC). Here, we evaluated efficacy and neurotoxicity humanized CD19-directed CAR-T R/R ALL CNSL NC. Of 12 enrolled patients, 4 had bone marrow (BM) testicular recurrence, 3 BM relapses NC, 5 relapse without...
e13565 Background: Radiotherapy and concurrent chemotherapy with Temozolomide (TMZ) have myelosuppressive effect, thrombocytopenia is commonly seen in this patient population 5-10% of glioblastoma (GBM) patients. There a lack data analyzing the it’s on progression free survival (PFS) or overall (OS) these The primary objective study was to identify degree newly diagnosed GBM patients receiving TMZ based chemoradiation (CRT). Secondary objectives included associations between PFS, OS....
Objective To analyzed the expression and clinical characteristics of CD20 marker in children with B-lineage acute lymphoblastic leukemia (B-ALL) evaluated its medical significance assessing prognosis disease. Methods From November 2008 to July 2012,125 cases were collected from Shanghai Children′s Hospital,including 79 males 46 females,aged between 2 months 14 years old.Flow cytometry based immunophenotyping Minimal Residual Disease (MRD) screening applied these when newly...
Purpose: Rates of screening and surveillance colonoscopy are limited by multiple factors, including patient nonadherence. We sought to define predictors for nonadherence in a large cohort patients who had ordered either colorectal cancer (CRC) or polyp surveillance. Methods: The primary study outcome was nonadherence, defined as failure complete within 120 days post-bowel preparation scheduled colonoscopy. Possible determinants included: demographics, ordering physician (gastroenterologist...