A5044079618- Peptidase Inhibition and Analysis
- Osteomyelitis and Bone Disorders Research
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Inflammasome and immune disorders
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Mast cells and histamine
- Boron Compounds in Chemistry
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Vitamin K Research Studies
- Pressure Ulcer Prevention and Management
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Spondyloarthritis Studies and Treatments
- Uterine Myomas and Treatments
- Osteoarthritis Treatment and Mechanisms
Zhejiang Chinese Medical University
2025
North Sichuan Medical University
2024
Peking Union Medical College Hospital
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
China-Japan Friendship Hospital
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Education Department of Jiangxi Province
2024
81th Hospital of PLA
2023
Chongqing Medical University
2022
Southern Medical University
2017
Fibroblast activation protein contributes to immunosuppression and resistance immunotherapies. This study aimed compare baseline 68Ga-labeled fibroblast inhibitor (68Ga-FAPI) PET/CT 18F-FDG in response survival prediction unresectable hepatocellular carcinoma (uHCC) patients treated with the combination of programmed cell death 1 (PD-1) lenvatinib. Methods: In this prospective cohort study, 22 uHCC who underwent 68Ga-FAPI soon began taking a PD-1 lenvatinib were recruited. Semiquantitative...
Introduction: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disorder without standardized treatment. Janus kinase (JAK) inhibitors can block a range of cytokines might possess significant anti-inflammatory activity. Here, we report the first case efficacious treatment refractory SAPHO with JAK inhibitor tofacitinib. Case presentation: A 44-year-old woman presented arthralgia in right wrist complained having difficulty doing housework....
Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration action, quick smooth recovery. However, pharmacokinetic characteristics continuous infusions correlation between plasma concentration bispectral index (BIS) elderly patients are still unknown. In this randomized, controlled study, thirty (62–78 years old) undergoing elective gastrointestinal tumor resection...
To explore the patterns of osteoarticular involvement in SAPHO syndrome. Baseline clinical characteristics and imaging data 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out 164 patients diagnosed with The twelve most frequently involved sites analysed by hierarchical cluster analysis Ward minimum-variance method. Three distinctive identified: spinal type (70 patients, 44.6%), predominantly thoracic, lumbar or sacral vertebral lesions; costal (52 33.1%), lesions...
Objective The study aimed to compare the effectiveness and safety of ultrasound-guided microwave ablation (MWA) percutaneous sclerotherapy (PS) for treatment large hepatic hemangioma (LHH).
Despite the potential of mesenchymal stromal cells (MSCs) in osteoarthritis (OA) treatment, challenge lies addressing their therapeutic inconsistency. Clinical trials revealed significantly varied outcomes among patients receiving same allogenic MSCs but different treatment regimens. Therefore, optimizing personalized strategies is crucial to fully unlock MSCs' and enhance consistency. We employed XGBoost algorithm train a self-collected database comprising 37 published clinical reports...
To estimate the incidence, prevalence and incidence-based mortality in patients with gynecologic sarcoma (GS), described trends of survival initial treatments US by using Surveillance, Epidemiology, End Results (SEER) database.GS cases aged 20 years or older between 1975 2015 were identified from SEER 9 registries. Incidence, prevalence, estimated, all rates age adjusted to 2000 standard population presented as per 100,000 persons. Annual percentage change (APC) average APC (AAPC) calculated...
SAPHO syndrome is a rare disease characterized by inflammatory lesions on skin and bones. Diversified manifestation inadequate understanding of etiology has limited its diagnosis treatment. The co-occurrence other immune-mediated diseases strongly suggests an involvement autoimmunity in syndrome. However, the role largest population circulating immune cells, neutrophils, still not well explored. In this study, we performed RNA sequencing to profile mRNA expression neutrophils purified from...
Erdheim-Chester disease (ECD) involves multiple organs and tissues has diverse manifestations, which makes it difficult to distinguish lesions caused by ECD from those other diseases. Variable degrees of fibrosis are present in ECD. Therefore, we conducted a prospective cohort study explore the ability 68Ga fibroblast activation protein inhibitor (68Ga-FAPI) PET/CT detect patients. Methods: Fourteen patients diagnosed with ECD, as confirmed histology, were included this study. For every...
Abstract A 58-year-old man was enrolled in our 68 Ga-FAPI PET/MR study for evaluation of stroke etiology. He had left thalamus and cerebellum infarction 6 months ago, occipital lobe 2 years ago. showed focal uptake along the low segment basilar artery. We hypothesize that FAPI-avid plaque artery may account embolic events resulting downstream infarction. Thus FAP-targeted imaging have a potential detection vulnerable plaques.
We used an Akeso device to record the visual behavior of children with myopia in two learning modes. found that online class mode may increase near-viewing time and reduce outdoor compared traditional school be responsible for accelerating progression.We aimed explore effects different modes on progression among 9 11 years old.Forty-nine were included requested use a wearable objectively real from November 2019 2020; participants took classes mid-February early May 2020 during this period....
Quantitative DNA-image cytometry (ICM) is used to diagnose malignancy via detecting changes in DNA content. We aimed estimate the value of cytology, DNA-ICM, and their combination diagnosing pancreatic malignancy.One hundred twenty-one endoscopic ultrasound-guided fine-needle aspiration samples from 116 patients suspected for were examined by cytology DNA-ICM. Their results final diagnoses (malignancy or not) collected. Diagnostic values compared among combination.The DNA-ICM had a lower...
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Objectives: To compare the efficacy and safety of anterior temporal lobotomy (ATLo) lobectomy (ATLe) in drug-resistant lobe epilepsy.Methods: Patients diagnosed with pharmacoresistant epilepsy who underwent or performed by a single surgeon were retrospectively included. Every patient was followed up annually after surgery. The postoperative seizure outcome evaluation based on Engel ILAE classifications. We compared complications 2-year follow-up outcomes between ATLo group ATL group.Results:...
Abstract Extraneural metastases of primary brain tumors are rare. Here, we provided a case 19-year-old man presenting with 2 intra-abdominal masses, who had history intracranial germ cell and ventriculoperitoneal shunt implanted in order to alleviate obstructive hydrocephalus. The lesions showed intense FDG uptake were confirmed be by postoperative histopathology. 18 F-FDG PET scan could useful monitoring via shunt.
Objective: Different SSTR2 antagonists have been developed. This study aims to evaluate the impact of different peptides and chelators on diagnostic performance in well-differentiated NETs. Methods: In this prospective study, participants were equally randomized into 2 arms: arm A, would undergo a whole-body 68 Ga-NODAGA-LM3 PET/CT scan first day Ga-DOTA-LM3 second day; B, Ga-NODAGA-JR11 day. Biodistribution normal organs, lesion detection ability, tumor uptakes compared within each arm....
Objective To estimate the diagnostic value of cytology, DNA-ICM (DNA-image cytometry), cytology combined with for pancreatic malignancy, and to explore cut-off DNA-ICM. Methods Patients suspicious malignancy were retrospectively identified. In total, 145 EUS-FNA specimens acquired from 140 separate patients examined by DNA-ICM. Diagnostic values among combination techniques in detecting compared. Results Compared had a lower sensitivity (63.0% VS 82.4%) accuracy (69.7% 85.5%)....