A5100441544- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Circular RNAs in diseases
- Diverse Topics in Contemporary Research
- GDF15 and Related Biomarkers
- Trace Elements in Health
- Nerve injury and regeneration
- Transportation and Mobility Innovations
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Nutritional Studies and Diet
- Bone and Dental Protein Studies
- Microscopic Colitis
- Alzheimer's disease research and treatments
- Phytochemicals and Antioxidant Activities
- Developmental Biology and Gene Regulation
- RNA Interference and Gene Delivery
- Heavy Metal Exposure and Toxicity
- Fluoride Effects and Removal
- Inflammatory Bowel Disease
Shanghai Jiao Tong University
2017-2023
Renji Hospital
2016-2023
Shaanxi Provincial People's Hospital
2021
Qilu Hospital of Shandong University
2018
Chinese Center For Disease Control and Prevention
2017
Harbin Medical University
2017
Shanghai Cancer Institute
2016
Abstract Small extracellular vesicles (EVs), including exosomes, play multiple physiological roles. In neurodegenerative diseases, EVs can be pivotal in dispersing neuropathogenic proteins. This study investigates the role of neural stem cell (NSC)‐derived a transgenic (Tg) mouse model Alzheimer's disease (AD). Five weeks following treatment on 9‐month‐old APP/PS1 mice, effects NSC‐derived cognitive behavior, mitochondrial function, sirtuin1 (SIRT1), synaptic function and morphology,...
A disintegrin and metalloproteinase 10 (ADAM10) is the constitutive α-secretase that governs nonamyloidogenic pathway of β-amyloid precursor protein processing an attractive drug target for treating Alzheimer's disease. To date, little known about mechanism by which ADAM10 regulated in neurons. Using mouse primary cortical neurons, we show here NMDA receptor (NMDAR) activation led to upregulation genes encoding β-catenin proteins. Interestingly, was abolished inhibitors Wnt/β-catenin...
Abstract JOURNAL/nrgr/04.03/01300535-202407000-00040/figure1/v/2023-11-20T171125Z/r/image-tiff Mitochondrial dysfunction is a hallmark of Alzheimer's disease. We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex APP/PS1 mice. Because disease affects entire brain, further research needed to elucidate alterations metabolism brain as whole. Here, we investigated expression several important biogenesis-related cytokines multiple...
Cerebral amyloid angiopathy (CAA) is present in up to 90% of patients with Alzheimer's disease (AD), and may interact classical neuropathology exacerbate cognitive decline. Since growth differentiation factor 11 (GDF11) can activate vascular remodeling, we tested its effects on function neuroinflammatory changes AD model mice. We intravenously administered GDF11 or vehicle daily 12-month-old transgenic mice overexpressing the amyloid-β protein precursor (AβPP)/PS1). Cognitive was monitored...
To investigate the potential influence of dietary Se intake on mortality among Chinese populations.We prospectively evaluated all-cause, CVD and cancer risks associated with in participants Shanghai Women's Health Study (SWHS) Men's study (SMHS). Dietary was assessed by validated FFQ during in-person interviews. Cox proportional hazards models were used to calculate hazard ratios (HR) 95 % CI.Urban city China.Chinese adults (n 133 957).During an average follow-up 13·90 years SWHS 8·37 SMHS,...
Extracellular vesicles (EV) are important mediators of cell communication and physiology. EVs frequently investigated by transiently transfecting cells with plasmid DNA to produce modified protein(s) or nucleic acid(s) interest. DNA-transfection reagent complexes (DTC) approximately the same size as EVs, raising possibility that some purification procedures may fail separate these two species activity arising from carryover DTC be improperly attributed EVs. We find differential...
Abstract According to much research, neurodegeneration and cognitive decline in Alzheimer disease (AD) are correlated with alternations of neurotrophic factors such as nerve growth factor, brain‐derived glial cell–derived factor. The experimental illumination neural stem cell (NSC) transplantation eliminate AD symptoms is being explored frequently, we have acknowledged that may play a pivotal role improvement. However, the relation between reversal deficits after NSC directed not clearly...
High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been confirmed. In this study, we (1) investigated whether VEGF participates DC murine cells (RM-1), (2) down-regulated expression using low-frequency ultrasound microbubbles (UM), (3) further explored any synergistic effect on immunological activation....
As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide link between these two diseases. The present study compared the content function MPs from patients with ACS or without T2DM. healthy subjects (n=20), (n=24), T2DM (n=20) combined (n=24) were obtained. After incubating rat thoracic tissue MPs, effect on endothelial‑dependent vasodilatation, expression caveolin‑1 endothelial nitric oxide synthase...
Epidemiological investigations indicate that certain ingredients in tea bricks can antagonize the adverse effects of fluoride. Tea polyphenols (TPs), most bioactive ingredient bricks, have been demonstrated to be potent bone-supporting agents. ClC‑7 is known crucial for osteoclast (OC) bone resorption. Thus, this study, we investigated potential protective TPs against fluorosis using a mouse model and explored underlying mechanisms with particular focus on ClC‑7. A total 40, healthy,...
Abstract BACKGROUND Lignin extracted from Canna edulis Ker residues shows a strong inhibitory effect on α‐glucosidase and promoting α‐amylase. Protease activity inhibition may play key role in disease processes, such as metastasis, tumor invasion bacterial colonization. Hence, the present study, mechanism of lignin trypsin was examined, including interaction type, thermodynamic parameters, structure, reaction site molecular docking. RESULTS The isolated presented an with IC 50 value 1.35...