Accumulating evidence suggests a higher risk for cardiovascular diseases among individuals with mental disorders, but very little is known about the overall and specific groups of in people attention-deficit/hyperactivity disorder (ADHD). To fill this knowledge gap, we investigated prospective associations between ADHD wide range adults. In nationwide population-based cohort study, identified 5,389,519 adults born 1941 1983, without pre-existing diseases, from Swedish registers. The study...

•Nationwide multigenerational study of 292,274 family members people with biopsy-confirmed MASLD and comparators.•MASLD first-degree relatives had increased hazards HCC, major adverse liver outcomes liver-related mortality.•The absolute risk HCC was low, only one extra case per 900 over 20 years follow-up.•Spouses individuals also a higher relative developing outcomes.•Liver disease progressed more rapidly in concomitant diseases. Background & AimsMetabolic dysfunction-associated steatotic...

SummaryBackgroundCeliac disease (CeD) may be associated with elevated liver enzymes. However, little is known about the risk of chronic (CLD) various etiologies or major adverse outcomes (MALO) in CeD. We aimed to investigate long-term CLD patients CeD.MethodsSwedish nationwide cohort study. identified 48,027 biopsy-confirmed CeD between 1969 and 2017. Each patient was exactly matched ≤5 general population reference individuals (n = 231,909) followed through 2021. Flexible parametric...

The objective was to assess the ability of eight commonly measured blood markers serve as prognostic biomarkers in amyotrophic lateral sclerosis (ALS).A cohort study conducted 399 individuals with newly diagnosed ALS between 2006 and 2011 Stockholm, Sweden. Information on markers, including creatinine, albumin, haemoglobin, C-reactive protein (CRP), glucose, potassium, sodium calcium, at or after date diagnosis, collected. Cox regression model joint were used explore associations risk...

Background Experimental observations have suggested a role of infection in the etiology neurodegenerative disease. In human studies, however, it is difficult to disentangle whether risk factor or rather comorbidity secondary event To this end, we examined 3 most common diseases relation previous inpatient outpatient episodes hospital-treated infections. Methods and findings We performed nested case-control study based on several national registers Sweden. Cases were individuals newly...

Dysregulation of inflammatory and immune responses has been implicated in the pathogenesis heart failure (HF). But even if inflammation is a prerequisite for bowel disease (IBD), little known about HF risk IBD.

Previous animal studies have suggested a disrupted intestinal microbiome in amyotrophic lateral sclerosis (ALS). Due to the known effect of antibiotics on gut microflora, potential role use risk ALS deserves an investigation.A nested case-control study was conducted using several Swedish national registers. In all, 2484 patients diagnosed between 1 July 2006 and 31 December 2013 were included as cases, five controls per case individually matched by sex, birth year area residence randomly...

Abstract Background Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its the elderly adults, especially oldest-old, is rarely explored. Methods In present cohort study, we prospectively explore among 15,092 participants enrolled Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep death information was collected by using structured questionnaires. Cox regression model with as time-varying exposure...

Patients with inflammatory bowel disease (IBD) are at an increased risk of thromboembolic events, but evidence on the long-term stroke remains scarce. We aimed to explore whether patients a biopsy-confirmed IBD had stroke.

Few studies have evaluated dietary antioxidant vitamins intake in relation to risk of mortality Asia.We examined the associations between total carotene, vitamin C, and E from diet all causes, cancer, cardiovascular disease 134,358 participants (59,739 men 74,619 women) Shanghai Men's Health Study Women's Study, two prospective cohort middle-aged elderly Chinese adults urban Shanghai. Participants were followed up for a median period 8.3 14.2 years women, respectively. Hazard ratios (HRs)...

Green tea is one of the most widely consumed beverages in Asia. While a possible protective role green against various chronic diseases has been suggested experimental studies, evidence from human studies remains controversial.We conducted this study using data Shanghai Men's Health Study (SMHS) and Women's (SWHS), two population-based prospective cohorts middle-aged elderly Chinese adults urban Shanghai, China. Hazard ratios (HR) 95% confidence intervals (CI) for risk all-cause...

Celiac disease (CeD) has been linked to an increased risk of other autoimmune diseases, yet the impact delayed CeD diagnosis on developing additional diseases remains uncertain. We investigated this through a nationwide matched case-control study.

Summary Background There are conflicting data on the risk of acute coronary syndrome (ACS) in patients with inflammatory bowel disease (IBD). Only a few previous reports include diagnosed during last decade. Aim To assess and compare ACS between IBD general population. Methods In this cohort study, we used nationwide registers to identify Sweden 2003–2021. Every patient was matched by birth year, sex, calendar year area residence up 10 population comparators. The primary outcome incident...

Abstract Aims/hypothesis While the association between coeliac disease and type 1 diabetes is well documented, of with 2 risk remains undetermined. We conducted a nationwide cohort Mendelian randomisation analysis to investigate this link. Methods This matched used data from Swedish ESPRESSO including 46,150 individuals 219,763 in comparator group selected general population, followed up 1969 2021. Data 9053 who underwent second biopsy were examine persistent villous atrophy diabetes....

This study aimed to investigate the effects of inactivated Lactiplantibacillus plantarum N1 and its bioactive substances alleviate insulin resistance. live bacteria heat killed plantarum...

Abstract Background Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, have been associated with an increased risk of venous thromboembolism (VTE). However, data on VTE is lacking in large population-based cohorts microscopic colitis (MC). We aimed to investigate the association between MC VTE. Methods included all Swedish adults (≥18 years) without previous (1990-2017, n=12,489, follow-up until 2021). subtypes (collagenous lymphocytic colitis) were defined from...

ABSTRACT Introduction Metabolic dysfunction‐associated steatotic liver disease (MASLD) has been linked to pancreatic diseases, but evidence from population‐based studies with histology is lacking. Aims and methods In this cohort including all Swedish adults ( n = 8563) biopsy‐proven MASLD, we aimed investigate incidences of diseases compared matched reference individuals the general population 38,858) full siblings 6696). Using Cox proportional hazard models, calculated multivariable...

We included 121,148 UK Biobank participants without IBD at baseline, and collected dietary information from a validated web-based 24-hour recall questionnaire. Overall glycemic index load was estimated. Cox proportional hazard models were used to calculate multivariable-adjusted ratios (HRs) 95% confidence intervals (CIs). Substitution analyses conducted test associations after replacing medium or high foods with low foods. During median follow-up of 10.6 years, 133 incident CD 335 UC cases...

Microscopic colitis (MC), comprising collagenous (CC) and lymphocytic (LC), is an inflammatory condition of the colon, characterized by watery diarrhoea. Previous studies suggest association between autoimmune thyroid diseases (AITDs) (Hashimoto's thyroiditis Graves' disease) MC; however, large-scale histology are lacking. We conducted a nationwide, matched case-control study. Patients with biopsy-confirmed MC diagnosed 2006 2017 were identified through population-based histopathology cohort...