A5046362912- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Pulmonary Hypertension Research and Treatments
- Amyotrophic Lateral Sclerosis Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastroesophageal reflux and treatments
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Dysphagia Assessment and Management
- Invertebrate Immune Response Mechanisms
- Tissue Engineering and Regenerative Medicine
- Studies on Chitinases and Chitosanases
- Parkinson's Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Eosinophilic Disorders and Syndromes
- Assisted Reproductive Technology and Twin Pregnancy
Karolinska Institutet
2007-2024
Karolinska University Hospital
2003
Background: Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with a poor prognosis.Fibroblasts and myofibroblasts are the key cells in fibrotic process.Recently two drugs, pirfenidone nintedanib, were approved for clinical use as they able to slow down progression.The mechanisms by which these drugs act vitro cell systems not known.The aim of this study was therefore examine effects nintedanib on fibroblasts structure function established from patients or without IPF.Methods:...
Abstract The Swedish Twin Registry functions as research infrastructure containing information on 216,258 twins born between 1886 and 2015, of whom 86,199 pairs have zygosity determined by DNA, an intrapair similarity algorithm, or being opposite sex. In essence, practically all alive currently 9 years older been invited for participation donation DNA which genomewide single nucleotide polymorphisms array genotyping has performed. Content, management alternatives future improvements are discussed.
The objective was to assess the ability of eight commonly measured blood markers serve as prognostic biomarkers in amyotrophic lateral sclerosis (ALS).A cohort study conducted 399 individuals with newly diagnosed ALS between 2006 and 2011 Stockholm, Sweden. Information on markers, including creatinine, albumin, haemoglobin, C-reactive protein (CRP), glucose, potassium, sodium calcium, at or after date diagnosis, collected. Cox regression model joint were used explore associations risk...
Background Experimental observations have suggested a role of infection in the etiology neurodegenerative disease. In human studies, however, it is difficult to disentangle whether risk factor or rather comorbidity secondary event To this end, we examined 3 most common diseases relation previous inpatient outpatient episodes hospital-treated infections. Methods and findings We performed nested case-control study based on several national registers Sweden. Cases were individuals newly...
Previous animal studies have suggested a disrupted intestinal microbiome in amyotrophic lateral sclerosis (ALS). Due to the known effect of antibiotics on gut microflora, potential role use risk ALS deserves an investigation.A nested case-control study was conducted using several Swedish national registers. In all, 2484 patients diagnosed between 1 July 2006 and 31 December 2013 were included as cases, five controls per case individually matched by sex, birth year area residence randomly...
Non-Helicobacter pylori microbiota might account for some cases with unexplained chronic gastritis that may in a minority eventually progress to gastric cancer through the Correa cascade. We characterized by describing normal stomach, compared it early precancerous lesions and other disease states, assessed whether H. status affects bacterial diversity.In population-based study of those without gastrointestinal symptoms, cytology brush samples were collected during endoscopy from 316...
SUMMARY Asthma is characterized by an eosinophilic inflammation and a subepithelial fibrosis in the airways. Eosinophils contain several cytotoxic substances, such as eosinophil cationic protein (ECP), which can promote cause tissue damage. This has generated hypothesis that eosinophils may drive remodelling of extracellular matrix (ECM). To investigate role we used vitro model for remodelling, three-dimensional collagen gel contraction assay. Two sources were this study, isolated human...
The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case‐control study with 448 cases their individually matched control subjects, based on the European Prospective Investigation into Cancer Nutrition (EPIC) cohort, to determine whether there was an altered associated chronic corpus atrophic gastritis. Conditional logistic regression models were applied calculate odds ratios (ORs) corresponding 95% confidence intervals (CIs),...
Abstract Eosinophil cationic protein (ECP) is a secretory of the eosinophil granulocyte, cell involved in innate immunity. Functional studies have implicated ECP numerous processes, such as tissue remodeling allergic inflammation and cytotoxicity toward variety pathogens. Recent genetic suggested that 434(G>C) polymorphism resulting an arg97thr substitution would alter function vivo. (in vitro) up until now either been conducted with native preparations containing unknown mixture...
Abstract Asthma is characterized by eosinophilic inflammation and remodelling of the airways. Eosinophil cationic protein (ECP) a released activated eosinophils hypothesis that ECP contributes to development structural changes in airways asthmatics has been posed. Fibroblast recruitment an important step process, we therefore put question whether stimulates migration human lung fibroblasts. Human peripheral isolated from buffycoats healthy individuals were cultured conditioned media (CM)...
Platelets are thought to play a role in variety of inflammatory conditions the lung, some which may lead fibrosis. In current study we tested hypothesis that whole platelets and platelet lysate can mediate remodelling extracellular matrix vitro by affecting fibroblast-mediated contraction collagen gel. We also sought determine what extent platelet-derived growth factor (PDGF) transforming factor-β (TGF-β) contribute this effect. Washed platelets, isolated from healthy blood donors, (freezing...
Background and aims: Oral microbiota may contribute to the development of upper gastrointestinal (UGI) disorders. We aimed study association between microbiome saliva, subgingival buccal mucosa, UGI disorders, particularly precancerous lesions. also determine which oral site might serve as most effective biomarker for Methods: In this population-based study, 388 adults underwent endoscopy with biopsies histopathological analysis. symptoms were assessed using a validated questionnaire 16S...
For targeted eradication of Helicobacter pylori (H. pylori) to reduce gastric cancer burden, a convenient approach is definitely needed. The purpose this study was evaluate the LAMP assay for H. detection using samples collected by noninvasive and self-sampling methods. available appraised verified reference clinically isolated strains. In addition, clinical conducted assess on 51 patients, from whom saliva, oral brushing samples, feces, corpus, antrum specimens were available....
Abstract Background The association between atrophic gastritis (AG) and symptomatic gastroesophageal reflux disease (GERD) needs to be better assessed. Objective We aimed study this in a twin setting, controlling for genetic familial factors, addition range of known covariates. Methods performed co‐twin control based on the Swedish Twin Registry, including confirmed monozygotic (MZ) dizygotic (DZ) twins. AG was determined by measurement serum pepsinogen I (PGI) II (PGII), with different...