A5100401134- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Lymphatic Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Systemic Sclerosis and Related Diseases
- IL-33, ST2, and ILC Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Medicinal Plants and Bioactive Compounds
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Neonatal and fetal brain pathology
- Cerebrovascular and genetic disorders
- Atherosclerosis and Cardiovascular Diseases
- Anesthesia and Neurotoxicity Research
- Lymphatic System and Diseases
- Urinary Bladder and Prostate Research
- Connexins and lens biology
Tongji Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Weatherford College
2021
Abstract Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in fibrosis is poorly explored. After TEC injury, various are released and among the most potent adenosine triphosphate (ATP), which via ATP-permeable channels. In these hemichannels, connexin 43 (Cx43) common member. However, its role interstitial (RIF) has not been fully examined. We analyzed samples patients with obstructive nephropathy mice unilateral ureteral obstruction (UUO). Cx43-KSP...
Background Lupus nephritis (LN) is a common and severe glomerulonephritis that often occurs as an organ manifestation of systemic lupus erythematosus (SLE). However, the complex pathological mechanisms associated with LN have hindered progress targeted therapies. Methods We analyzed glomerular tissues from 133 patients 51 normal controls using data obtained GEO database. Differentially expressed genes (DEGs) were identified subjected to enrichment analysis. Weighted gene co-expression...
White matter hyperintensity (WMH) is prevalent in older adults aged 60 and above. A large proportion of people with WMH have not experienced stroke little has been reported the literature.The case data patients ≥60 years without Wuhan Tongji Hospital from January 2015 to December 2019 were retrospectively analyzed. It was a cross-sectional study. Univariate analysis logistic regression used analyze independent risk factors for WMH. The severity assessed using Fazekas scores. participants...
Wang, Zheng; Hu, Danni; Pei, Guangchang; Yao, Ying; Xu, Gang; Zeng, Rui Author Information
Objective To investigate the effect of progesterone pretreatment focal cerebral ischemic and reperfusion injury (fCIRI) underlying molecular mechanisms. Methods A single intraperitoneal injection (8 mg/kg) given 1 h，48 h 96 before fCIRI was established in male Sprague-Dawley rats.The number survival neurons hippocampal CA1region ischemia-side，as well as spatial memory function，was detected on days 3-8 after fCIRI.Extracellular-signal-regulated kinase 1/2 phosphorylation (p-ERK1/2)...