A5070186988- Ion Transport and Channel Regulation
- Microscopic Colitis
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Pancreatic function and diabetes
- Eosinophilic Esophagitis
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Gastrointestinal motility and disorders
- Ion channel regulation and function
- Celiac Disease Research and Management
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Digestive system and related health
- Gastroesophageal reflux and treatments
- Pregnancy and Medication Impact
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Muscle metabolism and nutrition
- Immune Cell Function and Interaction
- Potassium and Related Disorders
Siloah St. Trudpert Klinikum
2019-2025
Medizinische Hochschule Hannover
2011-2021
ETH Zurich
2020
German Center for Infection Research
2014-2020
Winterthur Museum Garden and Library
2019
GTx (United States)
2018
Eli Lilly (Germany)
2007-2012
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2012
Universitätsklinikum Erlangen
2005
Martin-Luther-Krankenhaus
2005
This article is the second in a series of two publications relating to European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on management disease. The first covers medical management; present addresses surgical management, including preoperative aspects drug before surgery. It also provides technical advice for variety common clinical situations. Both articles together represent recommendations ECCO disease an update previous guidelines.
This is the second of a series two articles reporting European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on management adult patients with ulcerative colitis [UC]. The first article focused medical management, present addresses treatment acute severe [ASUC] surgical medically refractory UC patients, including preoperative optimisation, strategies, technical issues. provides advice for variety common clinical conditions. Together, represent an update recommendations ECCO UC.
An increased intramyocellular lipid (IMCL) content, as quantified by 1H-magnetic resonance spectroscopy (1H-MRS), is associated with reduced insulin sensitivity. At present, it unclear which factors determine IMCL formation and how rapidly accumulation can be induced. We therefore studied the impact of hyperinsulinemia elevated circulating nonesterified fatty acid (NEFA) levels on further evaluated influence a high-fat diet storage. In infusion protocol, 12 healthy male subjects underwent...
The existence of metabolically relevant intramyocellular lipids (IMCL) as assessed by the noninvasive 1H-magnetic resonance spectroscopy (MRS) has been established. In present studies, we analyzed relationships between IMCL in two muscle types [the predominantly nonoxidative tibialis (tib) and oxidative soleus (sol)] anthropometric data, aerobic capacity (VO2max, bicycle ergometry, n = 77) insulin sensitivity (hyperinsulinemic euglycemic clamp, 105) using regression analysis. univariate...
Inappropriate immune responses contribute to the continuous stimulation of intestinal system in chronic inflammatory bowel disease (IBD). Among several pathogenic factors, a numerical deficiency regulatory T (Treg) cells has been suggested lead an insufficient compensation chronically activated lymphocytes. This study was conducted investigate whether increased apoptosis contributes Treg cell IBD and successful treatment with antitumour necrosis factor α (TNFα) is achieved by reducing...
Ileocolonic luminal pH has been reported to be abnormally low in inflammatory bowel disease (IBD) patients, and one of the causative factors may reduced epithelial HCO secretory rate (J). Disturbances J occur due inflammation-induced changes crypt villous architecture, or effect proinflammatory cytokines on ion transporters. To discriminate between these possibilities, tumor necrosis factor alpha (TNF-α) overexpressing (TNF+/ΔARE) mouse model was chosen, which displays high cytokine levels...
Hypoglycemia causes recurrent morbidity in patients with type 2 diabetes. This study evaluated if exenatide twice daily (BID) was noninferior to premixed insulin aspart 70/30 BID (PIA) for glycemic control and associated less hypoglycemia.
To investigate the efficacy and safety of three different dosages embryonated, viable eggs Trichuris suis [TSO] versus placebo for induction remission in mildly-to-moderately active ileocolonic, uncomplicated Crohn's disease [CD]. Adults with CD [n = 252] randomly received six fortnightly doses 250, 2500, or 7500 TSO/15 ml suspension/day [TSO TSO 7500], 15 solution/day, a double-blind fashion, 4 weeks' follow-up. Primary endpoint was rate clinical [Crohn's Disease Activity Index [CDAI] <...
The influence of a short-term elevation free fatty acids (FFAs) on intramyocellular lipids (IMCL) under hyperinsulinemic conditions was monitored in five healthy male subjects the course 5-hr glucose clamp. During clamp lipid emulsion (Intralipid 20(R)) and heparin were administered intravenously. IMCL quantified tibialis anterior (TA) soleus (SOL) muscle by (1)H-MRS. A rapid pool found both muscles (61% TA 22% SOL) time period. control same study group, repeated without circulating FFAs,...
Despite the introduction of effective medical treatment peptic ulcer disease, bleeding is still a frequent complication. The aim this study was to investigate whether incidence and risk profile haemorrhage have changed within 10-year period.In prospective epidemiological observational in Düsseldorf, Germany were compared between two time periods (period A: 1.3.89-28.2.90 period B: 1.4.99-31.3.2000), involving nine hospitals with both surgical departments. Patients proven at endoscopy or...
Intestinal inflammation is often associated with an increased level of serotonin (5-HT), important gastrointestinal signaling molecule involved in gut homeostasis through stimulation specific receptors. In this study, we investigated the role 5-HT7 receptor (5-HT7R) induction and development intestinal using a mouse model acute chronic colitis human patients Crohn's disease (CD). Acute was induced administration dextran sodium sulfate to wild-type, 5-HT7R–deficient mice hematopoietic bone...
This was a multicentre case series supported by the European Crohn's and Colitis Organisation [ECCO] performed as part of Collaborative Network Exceptionally Rare reports [CONFER] project. The aim to report on whether cutaneous lesions associated with inflammatory bowel disease [IBD] refractory standard medical therapy including anti-tumour necrosis factors [anti-TNFs], would respond newer biologic agents ustekinumab [UST] or vedolizumab [VDZ]. includes 28 patients from 14 centres, all whom...
Background Prophylactic application of a haemostatic gel to the resection field may be an easy way prevent delayed bleeding, frequent complication after endoscopic mucosal (EMR). Objective We aimed evaluate if prophylactic directly EMR can reduce rate clinically significant bleeding events. Design conducted prospective randomised trial patients undergoing hot-snare flat lesions in duodenum (≥10 mm) and colorectum (≥20 at 15 German centres. clip closure was not allowed, but selective clipping...
The Na + /H exchanger isoform NHE2 is highly expressed in the intestinal tract, but its physiological role has remained obscure. aim of this study was to define expression, location, and regulatory properties murine colon look for compensatory changes (−/−) that allow normal histology absorptive function. To end, we measured proximal colonic surface crypt cell NHE1, NHE2, NHE3 expression levels, transport rates response acid, hyperosmolarity cAMP crypts, as well transcript levels...
The PDZ‐binding protein PDZK1 (NHERF3/CAP70/PDZ‐dc‐1) in vitro binds to NHE3, but its role the regulation of NHE3 activity native enterocytes is unknown. This study was undertaken understand physiological regulating murine colonic enterocytes. transport rates were assessed fluorometrically BCECF‐loaded crypts NHE3‐expressing cryptal openings by measuring acid‐activated, Na + ‐dependent, Hoe 642‐insensitive proton efflux rates. mRNA expression levels and total enterocyte brush border membrane...
A major causative factor of diarrhea in ulcerative colitis (UC) patients is the loss Na(+) absorptive capacity inflamed colonic mucosa. Potential contributing mechanisms include reduced driving force for active transport, and impaired expression, mislocalization, or defective transport function proteins. We therefore studied brush border membrane (BBM) localization, intestinal protein, Na(+)/H(+) exchanger isoform 3 (NHE3) biopsies from UC patients.In control biopsies, inflammation was...
Clostridium difficile infection (CDI) is a major cause of hospital-acquired diarrhea. Secondary bile acids were shown to confer resistance colonization by C. difficile. 7α-dehydroxylation key step in transformation primary secondary and required genes have been located single acid-inducible (bai) operon scindens as well hiranonis, two sp. recently reported protect against colonization.
Abstract Purpose To assess the muscular lipid content (LC) in different muscle groups of lower leg by a magnetic resonance imaging technique working with chemical shift selective excitation, and comparison anthropometric metabolic data. Materials Methods Examinations were performed 67 volunteers (54 male/13 female, age 29 ± seven years) on 1.5 T whole body imager, applying highly spectral‐spatial for fat MRI. LC was measured six calf muscles correlated mass index (BMI), percent (PFAT),...