A5073533050- Inflammatory Bowel Disease
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Immunodeficiency and Autoimmune Disorders
- Gallbladder and Bile Duct Disorders
- Tuberculosis Research and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical studies and practices
- Intraperitoneal and Appendiceal Malignancies
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Gastrointestinal motility and disorders
- Colorectal Cancer Screening and Detection
- Pregnancy and Medication Impact
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders Research
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
Comenius University Bratislava
2011-2023
University Hospital Bratislava
2006-2023
Czech Academy of Sciences
2019
Czech Academy of Sciences, Institute of Physiology
2019
Detská Fakultná Nemocnica s Poliklinikou
2016
Corvinus University of Budapest
2015
University of Rome Tor Vergata
2014
Azienda Ospedaliera Universitaria Pisana
2013
Grigore T. Popa University of Medicine and Pharmacy
2013
Institute of Social and Preventive Medicine
2013
This article is the second in a series of two publications relating to European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on management disease. The first covers medical management; present addresses surgical management, including preoperative aspects drug before surgery. It also provides technical advice for variety common clinical situations. Both articles together represent recommendations ECCO disease an update previous guidelines.
Summary Background: Major depressive disorder is the most common psychiatric diagnosis in Crohn's disease. In other chronic diseases, evidence suggests that depression influences course of Strong such a mediating role major disease has never been found. Aim: To assess relationship between and outcome treatment luminal with infliximab. Methods: this prospective study, 100 consecutive unselected patients underwent assessment psychosocial, demographical disease‐related biological clinical...
Summary Background : Infliximab treatment is effective in 70–80% of patients with refractory luminal and fistulizing Crohn's disease. The effect infliximab ascribed to induction apoptosis. Aim To study whether polymorphisms apoptosis genes predict the response they interact clinical predictors. Methods Cohort 287 consecutive treated for ( n = 204) or 83) disease was genotyped 21 genes. Short‐term assessed at week 4 (luminal disease) 10 (fistulizing after first infusion. Results rate 69% 80%...
Patients with ulcerative colitis and Crohn's have increased risk of colorectal cancer. Current screening endoscopy protocols based on white light (WLE) random biopsies are laborious uncertain sensitivity. Novel endoscopic techniques include chromoendoscopy (CE) confocal laser endomicroscopy (CLE).The aim was to compare WLE CE for the detection intraepithelial neoplasia (IEN). Furthermore, we analysed sensitivity specificity CLE diagnosis IEN.The cohort consisted 30 patients examined by WLE,...
Cholelithiasis and nonalcoholic fatty liver disease (NAFLD) share the same risk factors. The aim of our study was to explore relationship between these two conditions indentify independent predictors both diseases in a cohort patients with metabolic Consecutive factors referred outpatient clinic during one-year period were included. defined by presence gallstones on abdominal ultrasound examination at inclusion or previously performed cholecystectomy. NAFLD least one surrogate marker such as...
The aetiology of inflammatory bowel disease (IBD) is not known but likely to involve a combination genetic predisposition and environmental risk factors. Smoking has been associated consistently with higher Crohn's (CD), while appendectomy smoking appear diminish the ulcerative colitis (UC). roles other factors are unclear. aim present study was evaluate association CD UC several factors.This case-control included 338 patients (190 CD, 148 UC) 355 controls. All subjects completed detailed...
AIM:To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality life in inflammatory bowel disease (IBD) patients. METHODS:A cohort 220 IBD patients including 141 Crohn's (CD) 79 ulcerative colitis (UC) was followed-up at a tertiary center.A subgroup (n = 26) took supplements for > 3 mo.Health assessed using short questionnaire (sIBDQ).VD serum concentration sIBDQ score were between August October 2012 (summer/autumn period) February April 2013...
The inflammatory bowel disease questionnaire (IBDQ) is a frequently used outcome parameter in clinical trials. Whereas the validity and reproducibility of IBDQ have been extensively studied, there are limited data on its short-term responsiveness cutoff values for remission partial response.The score (BD), systemic (SysD), emotional (ED), social (SocD) dimensions were tested cohort 224 patients with Crohn's (CD) treated infliximab refractory luminal disease. Changes 4 weeks after therapy...
Infliximab (IFX) is an effective therapy for refractory luminal and fistulizing Crohn's disease (CD). Predictors of response could improve selection patients with a higher probability favorable outcomes the safety profile. We aimed to develop predictive model infliximab in CD.Genetic clinical data collected previous pharmacogenetic study apoptosis genes were analyzed using SAS Enterprise miner modeling software SPSS 12.0. proposed novel apoptotic index (API) score ranging from 0 (low...
AIMTo analyze 1-year liver injury burden in inflammatory bowel disease (IBD) patients. METHODSDuring a 6-mo inclusion period, consecutive IBD cases having control visit at center were included.Basic demographics, phenotype and treatment recorded on entry.Aminotransferase (AT) activities of ALT, AST, ALP gamma-glutamyl transpeptidase (GGT) measured baseline, 3 mo prior to study entry prospectively every for 1 year.Liver patterns predefined as: Grade ALT 1-3 × upper limit normal (ULN), grade 2...
Higher probability of the development Crohn's disease (CD) and ulcerative colitis (UC) as a possible consequence north-south gradient has been recently suggested. Living far north or south equator is manifested in fluctuation vitamin D (vitD) levels depending on season both healthy affected individuals. In present study we investigate link between seasonal serum vitD level to microbial composition lower gut Inflammatory Bowel (IBD) patients using 16S rRNA sequencing. Decrease winter/spring...
Background: The role of cell-free DNA (cfDNA) in the pathogenesis inflammatory bowel disease (IBD) has been recently suggested. aim this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity IBD patients clinical remission. Materials Methods: Plasma serum were obtained from 72 with Crohn's 28 ulcerative colitis. Total cfDNA, nuclear (ncDNA), mitochondrial (mtDNA) DNase measured. Results: showed higher levels both ncDNA mtDNA compared healthy controls. Concentration...
Aim: Osteoporosis is a known chronic complication of infl ammatory bowel diseases (IBD).The aim our study was to describe the prevalence reduced bone mineral density (BMD) in IBD patients and identify crucial risk factors for osteoporosis.Methods: The cohort consisted 76 patients, 40 with Crohn's disease (CD) 36 ulcerative colitis (UC).Clinical characteristics every patient were recorded, i.e. age, sex, duration disease, clinical behavior, location according Montreal classifi cation,...
Present methods for DNA isolation of stool have various limitations such as the amount used, requirement lavage fluids or use fresh stool. In this paper, a new method is described human nucleic acids from stool, which independent moment collection. Fecal samples dry possible were collected 75 patients; two grams mixed with lysis buffer containing phenol. yields crude variable and ranged 9–1686 μg/g feces. With dot blots in 9 cases, was identified 0.06%–46%. remaining 66 genomic detected by...
There is a high prevalence of low bone mineral density (BMD) among patients with inflammatory bowel disease (IBD) although there lack clinical data on the impact IBD specific medications and recommended vitamin D (VD) calcium (Ca) supplements it. The cohort consisted 150 patients. average change in BMD at lumbar spine per year (∆BMDL/year) was calculated characteristics, VD Ca analysed. osteopenia 69/150 (46%) osteoporosis identified 15/150 (10%) baseline. presence associated duration...
Background and Aims: CT-P13 is the first approved infliximab (IFX) biosimilar. It has proven equivalent to IFX treatment in several rheumatoid disorders; however, limited efficacy data available for its use inflammatory bowel disease (IBD). We evaluated clinical from our year using assess safety IBD patients. Methods: This retrospective cohort study included all consecutive Crohn’s (CD) or ulcerative colitis (UC) patients treated between March 2014 April 2015. Clinical remission was 14 weeks...
BACKGROUND AND AIMS: Relapse rates after discontinuing anti-tumor necrosis factor-α (TNFα) therapy of infl ammatory bowel disease (IBD) patients in deep remission are poorly understood.This prospective singlecenter open-label study evaluated the relapse IBD stopping anti-TNFα therapy.METHODS: All who were clinical and stopped 2011-2013 followed up for at least 12 months enrolled.The "Ultradeep" calprotectin-negative (<50 ng/g) six ceased on physician recommendations.The "clinical" but not...