A5042467408- Multiple Sclerosis Research Studies
- Vitamin D Research Studies
- Systemic Sclerosis and Related Diseases
- Bone health and osteoporosis research
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Thyroid Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Microscopic Colitis
- Psoriasis: Treatment and Pathogenesis
- RNA regulation and disease
- Respiratory Support and Mechanisms
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Dermatological and COVID-19 studies
- Neonatal Respiratory Health Research
- Polyomavirus and related diseases
- Inflammatory Bowel Disease
- Parkinson's Disease Mechanisms and Treatments
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Rheumatoid Arthritis Research and Therapies
Comenius University Bratislava
2009-2023
Martin University Hospital
2017-2018
University Hospital Bratislava
2014
Background Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are blood biomarkers that able to aid in the assessment of mild traumatic brain injury (mTBI) patients reduce computed tomography (CT) overuse. Objectives The aim this study was evaluate predictive performance individual their combination (i.e. mTBI assay) detecting clinically significant intracranial injuries mTBI. Furthermore, influence older age on investigated. Methods This prospective...
Objectives: Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis (MS). We hypothesised that extent HYP damage may determine severity MS and be associated with disease evolution. suggested fatigue depression depend on degree area.Method: 33 patients relapsing-remitting secondary progressive disease, 24 age sex-related healthy individuals (CON) underwent 1H-MR spectroscopy (1H-MRS) hypothalamus. Concentrations glutamate + glutamin (Glx), cholin...
Vitamin D acts through vitamin receptor (VDR) and has promising beneficial effects in the development progression of multiple sclerosis (MS). The purpose our study was to investigate possible association VDR gene polymorphisms ApaI, BsmI TaqI with MS susceptibility rate disease disability Central European Slovak population.The allele genotype variants were analysed 270 clinically diagnosed patients 303 healthy controls. Genotyping performed by polymerase chain reaction restriction analysis....
Since the positive role of thyrotropin (TSH) in bone remodeling has been recently emphasized, this cross-section study is aimed to evaluate association status with level TSH and free thyroxine (FT4) cohort postmenopausal women after long-term treatment thyroid disorders age matched controls.Urinary calcium (dUCa) serum TSH, FT4 turnover markers (BTMs) such as alkaline phosphatase (ALP), osteocalcin (OC), cross linked N-telopeptide type 1 collagen (NTx) well lumbar spine L 1-4 (BMD-L) femoral...
Objective:It is still unclear as to why multiple sclerosis (MS) so devastating and rapidly progressive in one patient less another. Recent data implicate vitamin D modulation of the risk well clinical course disease. Since acts through receptor (VDR), association single nucleotide polymorphisms (SNPs) VDR gene might account for variations MS within populations. The aim our study was determine between FokI polymorphism (rs10735810) a cohort Slovak population investigate possible correlations...
BACKGROUND: The causes of the individual differences in rate disability progression multiple sclerosis (MS) are still not completely clear.According to long-term prognosis MS patients, search for new valuable prognostic markers "benign" or "malign" is necessary.OBJECTIVES: Our aim was assess possible association onset age with disease Slovak patients MS.METHODS: By unique pattern evaluation using Multiple Sclerosis Severity Score (MSSS), each 270 defi ned as slow-progressing, mid-rate...
There is a high prevalence of low bone mineral density (BMD) among patients with inflammatory bowel disease (IBD) although there lack clinical data on the impact IBD specific medications and recommended vitamin D (VD) calcium (Ca) supplements it. The cohort consisted 150 patients. average change in BMD at lumbar spine per year (∆BMDL/year) was calculated characteristics, VD Ca analysed. osteopenia 69/150 (46%) osteoporosis identified 15/150 (10%) baseline. presence associated duration...
Meconium aspiration syndrome (MAS) triggers inflammatory and oxidative pathways which can inactivate both pulmonary surfactant therapeutically given exogenous surfactant. Glucocorticoid budesonide added to inhibit inflammation thereby enhance treatment efficacy. Neonatal meconium (25 mg/ml, 4 ml/kg) was administered intratracheally (i.t.) rabbits. When the MAS model prepared, animals were treated with i.t. (Pulmicort, 0.25 mg/kg, M+B); lung lavage (Curosurf®, 10 ml/kg, 5 mg phospholipids/ml,...
Multiple sclerosis (MS) is an inflammatory demyelinating disease that may cause physical disabling as well cognitive dysfunction. The presented study investigated how the neuropsychological status depends on thalamus and hippocampus's metabolic processes, using γ-aminobutyric acid-edited magnetic resonance spectroscopy (GABA-edited 1H MRS) in patients with early MS, results differ from healthy volunteers.We recruited 36 relapsing-remitting (RRMS) MS 22 controls (CON). In addition to common...
This cross-sectional study aimed to evaluate the interrelations between endogenous TSH level on one side and status of bone mineral density (BMD) metabolic turnover (BMT) other in pooled four groups premenopausal women either without or with a long-term L-thyroxine treatment.Serum levels free thyroxine (FT4), thyrotropin (TSH), calcium (Ca), alkaline phosphatase (ALP), osteocalcin OC) cross linked N-telopeptide type 1 collagen (NTx) as well urinary (U-Ca/24h), lumbar spine L 1-4 (BMD-L)...
Objective: The aim of the present study was to assess association between HLA-DRB1 and -DQB1 allele groups with genetic predisposition multiple sclerosis (MS) in Caucasian Central European Slovak population.Methods: A total 282 unrelated patients sporadic MS were enrolled this case-control study. HLA-DQB1 genotyped using a polymerase chain reaction sequence-specific primers. DRB1 DQB1 carrier frequencies, genotypes haplotype frequencies compared cases healthy controls.Results: Positive found...
Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung damage, inflammation, oedema formation, and surfactant dysfunction leading to hypoxemia. Severe ARDS can accelerate the injury of other organs, worsening patient´s status. There an evidence that tissue affects right heart function causing cor pulmonale. However, changes associated with are still poorly known. Therefore, this study evaluated oxidative inflammatory modifications in two experimental models induced New...
The effectiveness of bisphosphonate treatment for post-menopausal osteoporosis depends on patients adhering to the therapeutic regimen. We previously showed that prefer a once-monthly regimen and present follow-up study aimed analyse patients' motivation this preference. Women with (n = 2035) completed questionnaire targeting their preferences. majority had chosen due comfort (69%) simplicity (59%) need take fewer pills (55%). Friends, relatives print media were highlighted as important...
BackgroundThe latest diagnostic criteria for multiple sclerosis (MS) have revitalized the role of oligoclonal bands synthesis in cerebrospinal fluid (CSF-OCB). This study identifies predictors CSF-OCB-positivity among vivo metabolic markers subcortical gray/white matter MS patients after their first episode (CIS) and with relapsing-remitting course (RRMS).MethodsThe enrolled 13 CIS 23 RRMS patients. Metabolism was evaluated using Mescher-Garwood-edited proton-magnetic resonance spectroscopy...
Aim: To test the association between common TP53 haplotypes and colorectal cancer (CRC) development. Patients Methods: A total of 277 CRC patients 167 healthy volunteers were included in study. Common estimated from eight single-nucleotide polymorphisms (SNPs) (rs1614984, rs77697176, rs12947788, rs1800372, rs2909430, rs1042522, rs17878362 rs11652704). Stepwise haplotype trend regression showed haplotype-regressor cccgaRDa as a possible predictive marker. Results: The rare was identified 10...
Abstract Tumour necrosis factor (TNF)‐mediated signalling plays a key role in inflammatory and neurodegenerative processes leading to the development of multiple sclerosis (MS). Recent studies have highlighted tumour receptor superfamily member 1A (TNFRSF1A) gene encoding type 1 TNF genetic predisposition MS. This study aimed validate association TNFRSF1A rs1800693 rs4149584 polymorphisms with susceptibility MS Slovak population analyse their influence on age at disease onset, severity,...
The aim of our present study was to analyse the association HLA-DRB1 and -DQB1 alleles genotypes with Multiple Sclerosis (MS) disability progression in a cohort Central European Slovak population.The allele genotype variants were analyzed 282 non-related MS patients. Rate disease evaluated using EDSS score 5th, 7th, 10th, 15th year duration, time reach 3 5, MSSS score. Genotyping performed by polymerase chain reaction sequence-specific primers.We found that carriers homozygous for DRB1*15...