A5056567472- Clinical Laboratory Practices and Quality Control
- Meta-analysis and systematic reviews
- Bacterial Identification and Susceptibility Testing
- Acute Ischemic Stroke Management
- Healthcare cost, quality, practices
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reliability and Agreement in Measurement
- Adipose Tissue and Metabolism
- Hemodynamic Monitoring and Therapy
- Neonatal Health and Biochemistry
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Venous Thromboembolism Diagnosis and Management
- S100 Proteins and Annexins
- Statistical Methods in Clinical Trials
- Metabolism, Diabetes, and Cancer
- Cardiac Imaging and Diagnostics
- Renal function and acid-base balance
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Regional Development and Management Studies
Sisters of Charity Hospital
2015-2025
University of Zagreb
2009-2025
University Hospital Centre Zagreb
2019-2024
Hospital de Sant Pau
2023
University of Rijeka
2023
University of Gothenburg
2023
Centre Hospitalier Universitaire de Liège
2023
Croatian Science Foundation
2018-2022
Background: Results from hemolyzed, icteric, and lipemic samples may be inaccurate can lead to medical errors. These preanalytical interferences detected using visual or automated assessment. Visual inspection is time consuming, highly subjective not standardized. Our aim was assess the comparability of spectrophotometric detection lipemic, icteric hemolyzed samples.
An observational study was conducted in 12 European countries by the Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) to assess level compliance with CLSI H3-A6 guidelines.A structured checklist including 29 items created phlebotomy procedures guideline. A risk occurrence chart individual steps from observed error frequency severity harm each guideline key issue. The errors occurring during graded using chart.Twelve participated a...
Assay interferences have long been underestimated and unfortunately too often undetected in the daily clinical laboratory practice. The extra-analytical phase of testing process has recognized as major source errors over past decade. Preanalytical are most common within total hemolysis is one prevalent preanalytical surely interference testing. Visual detection arbitrary therefore mostly unreliable since it may over- underestimate actual prevalence hemolyzed serum specimens (i.e., trained...
Abstract Background: The preanalytical phase is the most common source of laboratory errors. goal this descriptive study was to analyze prevalence and type errors in relation site sample collection (inpatient vs. outpatient) unit (hematology coagulation biochemistry). For biochemistry unit, data were also analyzed relative analysis (stat routine). Methods: We retrospectively test request form error rate for a 1-year period, from January December 2008. Results: frequency differed...
Laboratory medicine is amongst the fastest growing fields in medicine, crucial diagnosis, support of prevention and monitoring disease for individual patients evaluation treatment populations patients. Therefore, high quality safety laboratory testing has a prominent role high-quality healthcare. Applied knowledge competencies professionals increases clinical value results by decreasing errors, increasing appropriate utilization tests, cost effectiveness. This collective paper provides...
The aim of our study was to perform verification serum indices on three clinical chemistry platforms.This done analyzers: Abbott Architect c8000, Beckman Coulter AU5800 (BC) and Roche Cobas 6000 c501. following analytical specifications were verified: precision (two patient samples), accuracy (sample with the highest concentration interferent serially diluted measured values compared theoretical values), comparability (120 patients samples) cross reactivity (samples increasing concentrations...
Highlights • Atellica UAS 60 provides results comparable to 800 Risk analysis identified 15 errors, mostly in the low-risk category, with unrecognized total crystals and mucus category +1 being most frequent, no errors classified as high risk Positive for non-squamous epithelial cells, hyaline pathological cast after automated image evaluation should be reviewed by laboratory personnel is suitable automating urine sediment low- mid-volume laboratories can serve an effective backup instrument larger
Background Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are blood biomarkers that able to aid in the assessment of mild traumatic brain injury (mTBI) patients reduce computed tomography (CT) overuse. Objectives The aim this study was evaluate predictive performance individual their combination (i.e. mTBI assay) detecting clinically significant intracranial injuries mTBI. Furthermore, influence older age on investigated. Methods This prospective...
Abstract Introduction Poor harmonization of critical results management is present in various laboratories and countries, including Croatia. We aimed to investigate procedures used reporting Croatian medical biochemistry (MBLs). Materials methods An anonymous questionnaire, consisting 24 questions/statements, related procedures, was send managers MBLs Participants were asked declare the frequency performing degree agreement with statements about values using a Likert scale. Total score mean...
Abstract Background: Manual handling of hemolyzed samples is not standardized and vulnerable to errors. This study aimed evaluate laboratory errors due manual assess the risk they might have for patient safety. Methods: Data were retrospectively obtained from a information system 25 emergency tests samples. Hemolysis (concentration free hemoglobin >0.5 g/L) was visually assessed by comparison with color chart. The reference person reestimated routinely degree hemolysis all (n=3185)...
Prostate cancer (PCa) is the most commonly diagnosed neoplasm among men. Since it often resembles benign prostate hyperplasia (BPH), biomarkers with a higher differential value than PSA are required. Epigenetic in liquid biopsies, especially miRNA, could address this challenge. The absolute expression of miR-375-3p, miR-182-5p, miR-21-5p, and miR-148a-3p were quantified blood plasma seminal 65 PCa 58 BPH patients by digital droplet PCR. sensitivity specificity these microRNAs determined...
While tissue biopsy has for the longest time been gold-standard in biomedicine, precision/personalized medicine is making shift toward liquid biopsies. Cell-free DNA (cfDNA) based genetic and epigenetic biomarkers reflect molecular status of its tissue-of-origin allowing early non-invasive diagnostics different pathologies. However, selection preanalytical procedures (including cfDNA isolation) as well analytical methods are known to impact downstream results. Calls greater standardization...
We redefined Robert's prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar that which occurs when major or veins are occluded animal models. With this redefinition, we used model examine cytoprotective effects stable gastric pentadecapeptide BPC 157. The induced lesions, intracranial (superior sagittal sinus) hypertension, severe brain swelling portal vena caval aortal hypotension,...
Introduction: Venous thromboembolic disease is one of the leading causes morbidity and mortality in developed world. Identification hereditary factors thrombophilia contributing to a better understanding etiology prevention. The aim this study was assess prevalence factor II G20210A, V Leiden, MTHFR (methylenetetrahydrofolate reductase) C677T PAI-1 (plasminogen activator inhibitor-1) 5G/4G polymorphisms healthy Croatian subjects patients with thromboembolism.