A5046638451- Clinical Laboratory Practices and Quality Control
- Meta-analysis and systematic reviews
- Healthcare cost, quality, practices
- Hemodynamic Monitoring and Therapy
- Clinical Reasoning and Diagnostic Skills
- Bacterial Identification and Susceptibility Testing
- Blood transfusion and management
- Sepsis Diagnosis and Treatment
- Potassium and Related Disorders
- Vitamin D Research Studies
- Statistical Methods in Clinical Trials
- Health and Medical Research Impacts
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Cardiomyopathy and Myosin Studies
- Blood groups and transfusion
- Renal function and acid-base balance
- RNA and protein synthesis mechanisms
- Ethics in Clinical Research
- Adrenal Hormones and Disorders
- Biosimilars and Bioanalytical Methods
- Central Venous Catheters and Hemodialysis
- Bone health and osteoporosis research
- Pharmacology and Obesity Treatment
- Medical Malpractice and Liability Issues
Worcestershire Acute Hospitals NHS Trust
2017-2024
Walter de Gruyter (Germany)
2022
Azienda Ospedaliera di Padova
2022
University of Padua
2022
New Cross Hospital
2009-2021
Association for Clinical Biochemistry and Laboratory Medicine
2015-2021
The Royal Wolverhampton NHS Trust
2013-2016
University of Birmingham
2002-2003
Merck (France)
2003
We evaluated the effect of systemic inflammatory response (SIR), as provoked by elective orthopaedic surgery, on serum vitamin D [25-(OH)D].Serum 25-(OH)D, binding protein (VDBP) and urinary VDBP were measured in 30 patients before 48-hours after knee or hip arthroplasty. C-reactive (CRP) was to assess SIR.The mean (SD) CRP increased following surgery [5.0 (5.5) vs 116.0 (81.2) mg/L; P<0.0001] did urine VDBP/Creatinine ratio [8 (9) 20 (25) pg/mmol; p=0.0004]. Serum 25-(OH)D [56.2 (30.3) 46.0...
Laboratory diagnostics develop through different phases that span from test ordering (pre-preanalytical phase), collection of diagnostic specimens (preanalytical sample analysis (analytical results reporting (postanalytical phase) and interpretation (post-postanalytical phase). Although laboratory medicine seems less vulnerable than other clinical areas, the chance errors is not negligible may adversely impact on quality testing patient safety. This article, which continues a biennial...
An observational study was conducted in 12 European countries by the Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) to assess level compliance with CLSI H3-A6 guidelines.A structured checklist including 29 items created phlebotomy procedures guideline. A risk occurrence chart individual steps from observed error frequency severity harm each guideline key issue. The errors occurring during graded using chart.Twelve participated a...
European questionnaire survey was conducted by the Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PA) to assess how phlebotomy is performed in EFLM countries, including differences personnel, level education skills, investigate presence compliance national guidelines on this matter.A constructed containing questions elucidating different aspects organization behind praxis a basis, staff performing phlebotomy, these members, existence...
Abstract It has been well reported over recent years that most errors within the total testing process occur in pre-analytical phase (46%–68.2%), an area is usually outside of direct control laboratory and which includes sample collection (phlebotomy). National international (WHO, CLSI) guidelines recommend order draw blood during phlebotomy should be culture/sterile tubes, then plain tubes/gel tubes containing additives. This prevents contamination with additives from previous could cause...
Venous blood sampling (phlebotomy) is the most common invasive procedure performed in patient care. Guidelines on correct practice of phlebotomy are available, including H3-A6 guideline issued by Clinical Laboratory Standards Institute (CLSI). As quality practices and procedures related to venous sample collection European countries was unknown, Federation Chemistry Medicine (EFLM) Working Group for Preanalytical Phase conducted an observational study 12 countries. The demonstrated that...
Abstract The European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE) was originally established in 2013, with main aims (i) promoting importance quality preanalytical phase testing process, (ii) establishing best practices providing guidance critical activities phase, (iii) developing disseminating surveys exploring concerning issues, (iv) organizing meetings, workshops, webinars or specific training courses on issues. As...
Abstract To ensure that clinical laboratories produce results are both accurate and of utility it is essential only samples adequate quality analysed. Although various studies databases assessing the stability analytes in different settings do exist, guidance on how to perform report lacking. This often not information, thus compromising transferability data. The aim this manuscript describe C hecklist for R eporting S tability tudies (CRESS) against which future should be reported...
Abstract Objectives Knowledge of the stability analytes in clinical specimens is a prerequisite for proper transport and preservation samples to avoid laboratory errors. The new version ISO 15189:2022 European directive 2017/746 increase requirements on this topic manufacturers laboratories. Within project generate database Federation Clinical Chemistry Laboratory Medicine (EFLM) Working Group Preanalytical Phase (WG-PRE), need standardise improve quality published studies has been detected,...
Background Most errors in the clinical laboratory occur preanalytical phase. This study aimed to comprehensively describe prevalence and nature of quality monitoring practices UK laboratories. Methods A survey was sent on behalf Association for Clinical Biochemistry Laboratory Medicine Preanalytical Working Group (ACB-WG-PA) all heads department laboratories UK. The captured data analytical platform Information Management System use; which were recorded how they classified gauged interest an...
Abstract The selection or procurement of blood collection devices in healthcare facilities is often an underestimated issue. This probably due to different factors including the lack knowledge policymakers, hospital administrators and even laboratory managers about importance preanalytical quality phlebotomy process, as well absence reliable guidelines recommendations on how precisely assess around globe. With awareness that a gap remains between manufacturers’ local validation devices,...
No guideline currently exists on how to detect or document haemolysis, icterus lipemia (HIL) in blood samples, nor subsequent use of this information. The EFLM WG-PRE has performed a survey for assessing current practices European laboratories HIL monitoring. This second part two coherent articles is focused HIL.An online survey, containing 39 questions preanalytical issues, was disseminated among member countries. Seventeen exclusively assessment, management and follow-up actions routine...
Background To study the detection and prevalence of spurious hyperkalaemia due to potassium ethylenediaminetetra-acetic acid (kEDTA) contamination. Methods In a one-month prospective study, serum EDTA, zinc, calcium, magnesium concentrations alkaline phosphatase activity were measured in samples with ≥6.0 mmol/L. Results Twenty-eight out 117 hyperkalaemic contaminated EDTA. Only zinc values below reference range had 100% sensitivity for indicating EDTA contamination, but even at an optimal...
Abstract It is now undeniable that laboratory testing vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite many advances made achieving a high degree quality safety in analytical part diagnostic testing, hurdles total process remain, especially preanalytical phase ranging from test ordering to obtaining managing biological specimens. The Working Group Preanalytical Phase (WG-PRE) European Federation Clinical Chemistry Laboratory Medicine (EFLM) has...
To investigate whether incorrect order of draw blood samples during phlebotomy causes in vitro potassium ethylenediaminetetraacetic acid EDTA (kEDTA) contamination samples.Serum kEDTA, potassium, calcium, magnesium, alkaline phosphatase, zinc and iron concentrations were measured drawn before after collecting into kEDTA containing sample tubes by an experienced phlebotomist using the Sarstedt Safety Monovette system.EDTA was undetectable all samples. The other analytes similar collection...
Background We studied the impact on reference intervals, classification of patients with hypoalbuminaemia and albumin infusion prescriptions changing from a bromocresol green (BCG) to purple (BCP) serum assay. Methods Passing-Bablok regression analysis Bland-Altman plot were used compare Abbott BCP Roche BCG methods. Linear was in-house an external laboratory results. Reference intervals for derived in two different laboratories using pathology data adult primary care. Prescriptions 20%...
To establish cutoff values for salivary liquid chromatography tandem mass spectroscopy cortisol and cortisone in defining adequate adrenocortical function during a standard synacthen test.We compared responses to those of serum measured on the Roche E170 immunoassay analyser Abbott Architect i2000 before 30 min 60 following 0.25 mg intravenous synacthen.Correlations were bimodal linear, respectively. Based these correlations, extrapolated from (Roche) cut-off 550 nmol/L defined as 15 45...