A5014503401- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
Yunnan University of Traditional Chinese Medicine
2016-2019
Luoyang Central Hospital Affiliated to Zhengzhou University
2016
Abstract Background MicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR‐497‐5p has been reported various human malignancies. However, the hepatocellular carcinoma (HCC) remains unclear. Results In this study, we found that was downregulated HCC tissues. The low level tumors correlated with aggressive clinicopathological characteristics predicted poor prognosis patients. overexpression significantly inhibited cell...
Abstract Growing evidence has demonstrated that single-nucleotide polymorphisms (SNPs) in the promoter of miRNA may influence individuals’ susceptibility to human diseases. We examined two SNPs rs10877887 and rs13293512 promoters let-7 family determine if were related occurrence breast cancer (BC). Genotyping was performed by PCR restriction fragment length polymorphism analysis or TaqMan assay 301 BC patients 310 age matched controls. found a higher frequency CC genotype C allele amongst...