A5085831921- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- Genetic diversity and population structure
- melanin and skin pigmentation
- Knee injuries and reconstruction techniques
- Disaster Response and Management
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Injury Epidemiology and Prevention
- Facial Rejuvenation and Surgery Techniques
- Sperm and Testicular Function
- Viral Infections and Vectors
- Aldose Reductase and Taurine
- Plant Disease Resistance and Genetics
- Viral Infections and Outbreaks Research
- Autophagy in Disease and Therapy
- Coenzyme Q10 studies and effects
- Academic integrity and plagiarism
- Signaling Pathways in Disease
- Lysosomal Storage Disorders Research
- Environmental DNA in Biodiversity Studies
- Acne and Rosacea Treatments and Effects
- Total Knee Arthroplasty Outcomes
Zhejiang University
2020-2025
Second Affiliated Hospital of Zhejiang University
2025
Zhejiang Cancer Hospital
2025
Albert Einstein College of Medicine
2024
Seoul Metropolitan Government
2024
Seoul National University
2024
Boramae Medical Center
2024
North Sichuan Medical University
2011-2024
West China Medical Center of Sichuan University
2005-2021
Hebei Medical University
2020
A growing number of studies have suggested microRNAs (miRNAs) are involved in the modulation myocardial ischemia-reperfusion (MI/R) injury; however, role endogenous miRNAs targeting endothelial cells (ECs) and its interaction with ICAM-1 setting MI/R remain poorly understood. Our microarray results showed that miR-146a, miR-146b-5p, miR-155*, miR-155, miR-497, miR-451 were significantly upregulated, whereas, miR-141 miR-564 downregulated ECs challenged TNF-α for 6 h. Real-time PCR analyses...
Abstract MicroRNA (miR)-143 and miR-145 have been identified as molecular regulators in cell proliferation, growth, clone formation, apoptosis, cycle, invasion, migration. We previously found that rs353292 the flanking region of miR-143/145 showed a high frequency patients with colorectal cancer (CRC). To identify whether polymorphism is risk factor for CRC, we conducted this study larger samples. A total 809 CRC 1005 gender matched controls were collected. The was genotyped by using TaqMan...
State estimation remains a fundamental challenge across numerous domains, from autonomous driving, aircraft tracking to quantum system control. Although Bayesian filtering has been the cornerstone solution, its classical model-based paradigm faces two major limitations: it struggles with inaccurate state space model (SSM) and requires extensive prior knowledge of noise characteristics. We present TrackDiffuser, generative framework addressing both challenges by reformulating as conditional...
Lysine acylation is a ubiquitous post-translational modification (PTM) that plays pivotal roles in various cellular processes, such as transcription, metabolism, protein localization and folding. Thousands of lysine sites have been identified based on advances antibody enrichment strategies, highly sensitive analysis by mass spectrometry (MS), bioinformatics. However, only 27 methacrylation (Kmea) exclusively histone proteins. It hard to separate, purify differentiate the Kmea from its...
Paraquat poisoning usually results from suicide, occupational, or accidental exposure. Herein, we report a rare fatal case of homicidal paraquat poisoning. A 58-year-old man was poisoned by taking paraquat-mixed medicine and wearing paraquat-soaked underwear. In the absence history exposure, patient misdiagnosed with pulmonary infection scrotal dermatitis died respiratory failure 24 days after initial exposure to paraquat. Ultra-performance liquid chromatography-tandem mass spectrometry...
The Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of disease remain unclear. Here, we investigated prognostic (EVD) through various statistical models.Sixty three laboratory-confirmed EVD patients with relatively complete clinical profiles were included in study. All recruited at Jui Government Hospital, Sierra Leone between October 1st, 2014 and January 18th, 2015. We first whether a single presentation would be...
The present study aimed to investigate the molecular mechanisms and effect of Beclin-1 on autophagy, proliferation apoptosis in colorectal cancer (CRC) HCT116 SW620 cells. was silenced by RNA interference (RNAi) HTC116 Reverse transcription-polymerase chain reaction western blot were used measure expression Beclin-1. percentage apoptotic cells analyzed cell counting kit-8 (CCK-8) flow cytometry (FCM). Cell cycle FCM MTT assay. created 3 groups two lines, consisting targeting siRNA (TS)...
Abstract Attrition of heterologous virus-specific CD8+ T cells has been demonstrated in murine viral infection; however, little is known regarding this phenomenon human infections. In study, we observed that CMV-specific displayed numerical decline and functional impairment the early phase acute infection, whereas programmed death-1 (PD-1) expression was significantly up-regulated by these cells. This PD-1 up-regulation found to be closely associated with increased apoptotic sensitivity The...
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression severity treatment response in colorectal cancer (CRC).Our sample size consisted of 139 CRC patients who were treated with surgery alone.Immunohistochemistry was used to investigate prognostic significance CRC, while weak normal tissue as basis for assessing tumors (control group).Real-time reverse transcription-polymerase chain reaction quantified miR-30a levels.The levels associated clinical variables...
In this study, a modified method of the conventional RNA dot-blot hybridization was established, by replacing (32)P labels with CY5 and nylon membranes positive-charged glass slides, for detecting plant viruses viroid. The named slide hybridization. optimum efficiency binding onto surfaces activated achieved using aminosilane-coated as solid matrix 5xsaline sodium citrate (SSC) spotting solution. Using CY5-labeled DNA probe prepared through PCR amplification, optimized could detect little...
Objective The aim of the study was to assess peripheral rim instability and clinical value discoid meniscus. Methods We retrospectively studied 79 magnetic resonance imaging (MRI) examinations meniscus from May 2017 September 2019. patient symptoms physical findings were documented. patients underwent “dedicated” 0.25 T supine weight-bearing MRI examination. Finally, all arthroscopy. Results Sound/clicking during motion ( P = 0.009) limited extension 0.044) subjective symptoms, clunk 0.035),...
Predicting the future risks of stroke for patients is in high demands. In this paper, we proposed a model predictive 1 year's period across all age, payor, and disease groups Maine, using demographics clinical histories extracted from Electronic Medical Record (EMR) notes provided by Health Information Exchange (HIE). A retrospective cohort 180,196 prospective 347,504 were constructed development validation, respectively. logistic regression based on multivariate analysis was built risk...