A5045102265- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Lung Cancer Treatments and Mutations
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Neuroendocrine regulation and behavior
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Genetic Neurodegenerative Diseases
- Central Venous Catheters and Hemodialysis
- RNA and protein synthesis mechanisms
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Silk-based biomaterials and applications
- Cardiomyopathy and Myosin Studies
- Cancer Cells and Metastasis
- Biotin and Related Studies
- Fungal and yeast genetics research
The University of Queensland
2017-2025
Zhejiang University
2024-2025
Park Centre for Mental Health
2017-2025
Third Hospital of Hebei Medical University
2017-2025
Hebei Medical University
2017-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Zhejiang Cancer Hospital
2025
Second Affiliated Hospital of Nanjing Medical University
2024
Tongji University
2024
Tongji Hospital
2024
Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) type 2 diabetes mellitus (T2DM) subjects investigated the relationships between glycolipid metabolism, insulin resistance, pancreatic β-cell function, inflammation.A total of 176 were enrolled study, including 88 patients with newly diagnosed T2DM normal glucose tolerance (NGT). NGT groups divided into normal-weight (NW) OB subgroups....
Transcription of new RNA is crucial for maintaining synaptic plasticity, learning and memory. Although the importance plasticity-related mRNAs well established, role a large group long non-coding RNAs (lncRNAs, > 200 bp) in long-term potentiation (LTP) not known. In this study, we demonstrated expression lncRNA cluster, namely Meg3, Rtl1-AS, Meg8 Meg9, which located maternally imprinted Dlk1-Dio3 region on mouse chromosome 12qF1, primary cortical neurons following glycine stimulation an NMDA...
The accumulation of soluble amyloid-β (Aβ) peptides produces profound neuronal changes in the brain during pathogenesis Alzheimer's disease. Excessive levels Aβ disrupt excitatory synaptic transmission by promoting removal AMPA receptors (AMPARs), dendritic spine loss, and depression. Recently, activity-dependent ubiquitination GluA1 subunit has been shown to regulate intracellular sorting AMPARs toward late endosomes for degradation. However, whether this ubiquitin signaling pathway...
Colorectal cancer is one of the most common malignant tumors in world, and about 50% its advanced patients will have liver metastasis. Preoperative assessment risk metastasis with colorectal great significance for making individualized treatment plans. Traditional imaging examinations tumor markers some limitations predicting Therefore, it clinical value to explore more sensitive specific predictive indicators improving early detection effect. In recent years, circulating cells (CTCs), as a...
Lysine acylation is a ubiquitous post-translational modification (PTM) that plays pivotal roles in various cellular processes, such as transcription, metabolism, protein localization and folding. Thousands of lysine sites have been identified based on advances antibody enrichment strategies, highly sensitive analysis by mass spectrometry (MS), bioinformatics. However, only 27 methacrylation (Kmea) exclusively histone proteins. It hard to separate, purify differentiate the Kmea from its...
Maintaining genomic integrity and faithful transmission of genetic information is essential for the survival proliferation cells organisms. DNA damage, which threatens genome, rapidly sensed repaired by mechanisms collectively known as damage response. The RNA demethylase FTO has been implicated in this process; however, underlying mechanism regulates repair remains unclear. Here, we use an unbiased quantitative proteomic approach to identify proximal interactome endogenous protein. Our...
Demixing of proteins and nucleic acids into condensed liquid phases is rapidly emerging as a ubiquitous mechanism underlying the complex spatiotemporal organisation molecules within cell. Long disordered regions low sequence complexity (LCRs) are common feature that form liquid-like microscopic biomolecular condensates. In particular, RNA-binding with prion-like have emerged key drivers demixing to condensates such nucleoli, paraspeckles stress granules. Splicing factor proline-...
Interleukin-25 (IL-25) has been proved to play a role in the pathogenesis and metastasis of Hepatocellular carcinoma (HCC), but relationship between level IL-25 prognosis HCC is still not clear. This study aimed investigate expression other potential biochemical indicators among healthy people, HBV-associated patients without lung with metastasis.
Upon DNA damage, numerous proteins are targeted for ubiquitin-dependent proteasomal degradation, which is an integral part of the repair program. Although details ubiquitination processes have been intensively studied, little known about whether and how 26S proteasome regulated in damage response (DDR). Here, we show that human Rpn10/PSMD4, one three ubiquitin receptors proteasome, rapidly phosphorylated to different types damage. The phosphorylation occurs at Rpn10-Ser266 within a conserved...
Whether an endobronchial ultrasound (EBUS) is required for transbronchial needle aspiration (TBNA) in the diagnosis of mediastinal masses currently a disputed subject. Previous studies have demonstrated that EBUS-TBNA performs better compared to conventional TBNA as it capable sampling real-time with TBNA. However, some clinicians consider be sufficient diagnosis. In this meta-analysis, we evaluated these two methods according diagnostic yield. A search was conducted through PubMed, Embase...
Abstract Latent bioreactive unnatural amino acids (Uaas) have been widely used in the development of covalent drugs and identification protein interactors, such as proteins, DNA, RNA carbohydrates. However, it is challenging to perform high-throughput Uaa cross-linking products due complexities samples data analysis processes. Enrichable Uaas can effectively reduce simplify analysis, but few cross-linked peptides were identified from mammalian cell with these Uaas. Here we develop an...
Background: Patients with coronavirus disease 2019 (COVID-19) can present gastrointestinal (GI) symptoms. However, the prevalence of GI symptoms and their association outcomes remain controversial in COVID-19 patients. Methods: All patients consecutively admitted to Wuhan Huoshenshan hospital from February 2020 April were collected. Disease severity compared between without Logistic regression analyses performed evaluate composite endpoint death A was defined as transfer intensive care unit,...
Abstract MicroRNAs (miRNAs) have been implicated in a wide range of biological processes including angiogenesis. MiR‐204 was identified as tumor suppressor multiple cancer types, lung adenocarcinoma. However, the function miR‐204 angiogenesis remains unknown. In this study, we found that expression decreased adenocarcinoma based on genome atlas (TCGA) analysis and gain‐of‐function experiment showed promoted cell apoptosis suppressed proliferation, migration vitro growth vivo . Functionally,...
Abstract Progressive supranuclear palsy (PSP) is a late‐onset neurodegenerative disease defined pathologically by the presence of insoluble phosphorylated‐Tau (p‐Tau) in neurons and glia. Identifying co‐aggregating proteins within p‐Tau inclusions may reveal important insights into processes affected aggregation Tau. We used proteomic approach, which combines antibody‐mediated biotinylation mass spectrometry (MS) to identify proximal PSP. Using this proof‐of‐concept workflow for identifying...
Acute lung injury (ALI) is a serious and common complication that occurs in children with congenital heart disease after cardiopulmonary bypass (CPB) surgery, leading to higher mortality rates poorer prognosis. Currently, there no reliable predictive strategy for CPB-associated (CPB-ALI) infants. Certain characteristics of the gut microbiota could potentially serve as biomarkers predicting development CPB-ALI.
Abstract Coronavirus disease (COVID-19) patients frequently develop liver biochemical abnormality. However, abnormality in COVID-19 with cirrhosis is under-recognized. Patients hospitalized during pandemic China (ie, from February to April 2020) were screened. All of 17 consecutively admitted the Wuhan Huoshenshan Hospital identified. Meanwhile, age-, sex-, and severity-matched without this hospital selected as a control group; all 14 cirrhotic Department Gastroenterology General Northern...