A5084638807- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Advanced Drug Delivery Systems
- Pneumocystis jirovecii pneumonia detection and treatment
- Toxin Mechanisms and Immunotoxins
- Organic Light-Emitting Diodes Research
- Dermatologic Treatments and Research
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Electrocatalysts for Energy Conversion
- Natural product bioactivities and synthesis
- Plant Pathogens and Fungal Diseases
- Advanced Photocatalysis Techniques
- Polyomavirus and related diseases
- Phytoplasmas and Hemiptera pathogens
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Multicomponent Synthesis of Heterocycles
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Hydrogels: synthesis, properties, applications
Tongji University
2020-2024
Shanghai Changzheng Hospital
2008-2022
Guangdong Academy of Sciences
2020-2021
Second Military Medical University
2008-2020
China Guangzhou Analysis and Testing Center
2019
World Wide Web Consortium
2003
Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and gattii. Distinction between the two species based on phenotypic genotypic characteristics. Recently, it was proposed that C. be divided into gattii five phylogenetic analysis 115 isolates. While this proposal adds to knowledge about genetic diversity population structure cryptococcosis agents, published genotypes 2,606 strains have already revealed more than encompassed seven species....
Cryptococcosis is caused by either Cryptococcus neoformans or C. gattii. While cryptococcal meningoencephalitis mostly in immunocompromised patients, the risk factors remain unclear for patients with no known immune defect. Recently, anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies were detected plasma of seven "immunocompetent" cryptococcosis and strains from these reported as (three strains), gattii (one strain), not identified to species level). We all three...
Abstract To determine the population structure of cryptococcosis agents in China, we analyzed genotype 120 Cryptococcus neoformans and 9 gattii strains isolated from 1980 through 2006 patients residing 16 provinces mainland China. A total 71% (91/129) clinical 1985 were without any apparent risk factors. Only 8.5% (11/129) AIDS patients; remaining 20.5% (27/129) with underlying diseases other than HIV infection. One hundred twenty 129 isolates C. serotype A, mating type MATα that exhibited...
Abstract CoMo 2 S 4 2D nanosheets are constructed by a hard template‐limited domain strategy, meanwhile the hydrogen evolution reaction (HER) properties and function of Co in systematically investigated. Electrochemical tests show that possesses high HER performance with an overpotential 55 150 mV at 10 100 mA cm −2 , respectively, outperforming Pt/C (20%) state art Mo–S, Co–S, Co–Mo–S‐based materials. An in‐depth mechanism study reveals main active site is Mo rather than Co, whereas plays...
Amphotericin B (AmB)/poly(lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) nanoparticles coated with polysorbate 80 (Tween-80) were prepared by nanoprecipitation for transport across the blood–brain barrier (BBB). The effects of Tween-80 on size and distribution, entrapment efficiency release behavior AmB/PLA-b-PEG investigated. Furthermore, brain targeting curative effect also was significantly enhanced when Tween-80. spherical homogeneous distribution. Drug concentration in mice greatly...
Abstract: Amphotericin B deoxycholate (AmB), a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate cryptococcal meningitis due to its inability pass through blood–brain barrier (BBB). We examined efficacy amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs) modified with polysorbate 80 that had mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm). AmB-PBCA-NPs were detected in brain 30 minutes after...
The C. neoformans and gattii species complex causes cryptococcosis. is known as an opportunistic pathogen since it primarily infects immunocompromised patients. has been referred to a primary due its high infection frequency in apparently immunocompetent people.
Solar keratosis, also known as actinic keratosis (AK), is becoming increasingly prevalent. It a benign tumor that develops in the epidermis. Individuals with AK typically exhibit irregular, red, scaly bumps or patches result of prolonged exposure to UV rays. These growths primarily appear on sun-exposed areas skin such face, scalp, and hands. Presently, dermatologists are actively studying due its rising incidence rate United States. However, underlying causes remain poorly understood....
To describe clinical characteristics, treatment and outcome of cryptococcal meningitis in immunocompetent children. Immunocompetent children with who attended Changzheng Hospital between 1998 2007 were retrospectively reviewed. During the 10 years reviewed, 11 admitted to hospital identified as immunocompetent. The had a median age 7.25 years. Headache (100%), fever (81.8%), nausea or vomiting (63.6%) visual hearing damage loss (36.4%) most common symptoms before treatment. There is no...
Cryptococcosis is a significant invasive fungal infection with noteworthy morbidity and mortality that usually caused by either Cryptococcus neoformans (C. neoformans) or gattii gattii). Epidemiological studies have indicated C. are more often reported in immunocompromised immunocompetent patients. It has been well established the cytokine profile of host markedly affects outcome cryptococcal disease, negative regulators microRNAs(miRs miRNAs) critically important for immunomodulation....
Cryptococcal meningitis is a fungal infectious disease with poor prognosis and high mortality. Amphotericin B (AMB) the first choice for treatment of cryptococcal meninges. The blood-brain barrier (BBB) major effective delivery drugs to brain. In this study, AMB was incorporated in thermosensitive gel intrathecal injection. We synthesized AMB-loaded thermogel, investigated its vitro cumulative release, vivo neurotoxicity, therapeutic effect. comprised 25 wt% poly (lactic acid-co-glycolic...
Although cryptococcosis is widely recognized as infection by Cryptococcus neoformans sensu lato from environmental sources, information concerning the characteristics of isolates C. s. l. and how they are related to clinical very limited, especially in East China. In this study, 61 were recovered pigeon (Columba livia) droppings Yangtze River Delta region These genotyped using ISHAM-MLST consensus scheme their antifungal drug susceptibilities determined following CLSI M27-A3 guidelines. The...
We present a case of primary cutaneous aspergillosis caused by Aspergillus terreus in patient with T-cell lymphoma. A 41-year-old woman bruised her left shin and presented 1 x 2 cm ecchymosis on the upper third for over 6 months. Before mycological examination sequential biopsies, was erroneously treated antibiotics local debridement. After final diagnosis A. lymphoma basis mycological, histopathological immunohistochemical findings, responded well to oral itraconazole chemotherapy month.