A5048455784- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Nanoplatforms for cancer theranostics
- bioluminescence and chemiluminescence research
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Immune Cell Function and Interaction
- Molecular Communication and Nanonetworks
- Physical Unclonable Functions (PUFs) and Hardware Security
- T-cell and B-cell Immunology
- Antimicrobial Peptides and Activities
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- Vanadium and Halogenation Chemistry
- Metal complexes synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
Memorial Sloan Kettering Cancer Center
2019-2023
Cornell University
2023
Stony Brook University
2013
T cell receptor (TCR) signal strength is a key determinant of responses. We developed cancer mouse model in which tumor-specific CD8 cells (TST cells) encounter tumor antigens with varying TCR strength. High-signal-strength interactions caused TST to up-regulate inhibitory receptors (IRs), lose effector function, and establish dysfunction-associated molecular program. undergoing low-signal-strength also up-regulated IRs, including PD1, but retained cell-intrinsic functional state....
Abstract Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells the microenvironment endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAFV600E. GABA synthesized cells, then acts on GABA-A receptors keratinocytes. Electron microscopy...
We report the synthesis and characterisation of mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes, which were used as potential photodynamic therapeutic agents for melanoma cell growth inhibition. The novel [Ru(pbt)2(phen2DTT)](PF6)2·1.5H2O 1 (where phen2DTT = 1,4-bis(1,10-phenanthrolin-5-ylsulfanyl)butane-2,3-diol pbt 2-(2'-pyridyl)benzothiazole) [Ru(pbt)2(tpphz)](PF6)2·3H2O 2 tpphz tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) synthesised characterised. Compound was...
<p>Combined supplementary figures and figure legends. Supplementary Fig. 1: Switching requires direct contact between nascent melanoma cells keratinocytes in vivo. 2: vitro. 3: does not involve cell fusion cells. 4: Exosome-like vesicles are transferred from to keratinocytes. 5: GABAergic signaling is active skin 6: Melanoma express GAD1 produce GABA. 7: Disruption of GABA blocks melanoma/keratinocyte communication. 8: Specialized cell-cell junction signatures enriched 9: present near...
<p>Combined supplementary figures and figure legends. Supplementary Fig. 1: Switching requires direct contact between nascent melanoma cells keratinocytes in vivo. 2: vitro. 3: does not involve cell fusion cells. 4: Exosome-like vesicles are transferred from to keratinocytes. 5: GABAergic signaling is active skin 6: Melanoma express GAD1 produce GABA. 7: Disruption of GABA blocks melanoma/keratinocyte communication. 8: Specialized cell-cell junction signatures enriched 9: present near...
<p>3D rendering of melanoma/switched keratinocyte contacts and stained vesicles in human melanoma/keratinocyte co-cultures</p>
<p>3D rendering of gephyrin positive clusters in melanoma/keratinocyte co-cultures</p>
<p>3D rendering of melanoma/switched keratinocyte contacts and stained vesicles in human melanoma/keratinocyte co-cultures</p>
<p>Representative trace videos of spike activity in melanoma/keratinocyte co-cultures +/- GABA signaling</p>
<p>3D rendering of melanoma/keratinocyte contacts in zebrafish embryos</p>
<p>Representative trace videos of spike activity in melanoma/keratinocyte co-cultures +/- GABA signaling</p>
<p>3D rendering of melanoma/keratinocyte contacts in zebrafish embryos</p>
<p>3D rendering of gephyrin positive clusters in melanoma/keratinocyte co-cultures</p>
<div>Abstract<p>Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells the microenvironment endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAFV600E. GABA synthesized cells, then acts on GABA-A receptors keratinocytes....
<p>3D rendering of gephyrin positive clusters in melanoma/keratinocyte co-cultures</p>
<div>Abstract<p>Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells the microenvironment endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAF<sup>V600E</sup>. GABA synthesized cells, then acts on GABA-A...
<div>Abstract<p>Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells the microenvironment endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAFV600E. GABA synthesized cells, then acts on GABA-A receptors keratinocytes....
<p>Representative trace videos of spike activity in melanoma/keratinocyte co-cultures +/- GABA signaling</p>