A5054512826- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Chronic Kidney Disease and Diabetes
- Computational Drug Discovery Methods
- Electrolyte and hormonal disorders
- Genomics, phytochemicals, and oxidative stress
- IL-33, ST2, and ILC Pathways
- Medicinal Plants and Bioactive Compounds
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Clusterin in disease pathology
- Free Radicals and Antioxidants
- Climate Change and Health Impacts
- Flavonoids in Medical Research
- Lipid metabolism and disorders
- Saffron Plant Research Studies
- Renal cell carcinoma treatment
- Pharmaceutical studies and practices
- Metabolomics and Mass Spectrometry Studies
- Global Health Care Issues
Nanjing University
2015-2020
Shanghai Institute of Hypertension
1992
Particulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as lung, brain liver. However, its effects on renal the underlying molecular mechanism have not been understood. The inactive rhomboid protein 2 (iRhom2), also known family member (Rhbdf2), necessary modulator shedding of tumor necrosis factor-α (TNF-α) in immune cells, has explored pathogenesis chronic diseases. In present study, we found that compared to wild type (iRhom2+/+) mice, iRhom2 knockout...
Obesity-related renal disease is related to caloric excess promoting deleterious cellular responses. However, a full understanding of the molecular mechanisms involved in progressive kidney disease, as well therapeutic strategy, still absent. Fisetin (FIS), natural flavonoid, possesses various bioactivities number models. its role obesity-associated injury unclear and requires elucidation. In our study, an obesity animal model was established using C57BL/6 mice fed with normal chow diet...
Research suggests that particulate matter (PM2.5) is a predisposing factor for metabolic syndrome-related systemic inflammation and oxidative stress injury. TNF-α as major pro-inflammatory cytokine was confirmed to participate in various diseases. Inactive rhomboid protein 2 (iRhom2) recently determined necessary regulator shedding of immune cells. Importantly, kidney-resident macrophages are critical inflammation-associated chronic renal Podocyte injury can be induced by stimulants give...
Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD).
High fructose intake promotes hepatic lipid accumulation. Pterostilbene, a natural analogue of resveratrol found in diet berries, exhibits hepatoprotective property. Here, we studied the protection by pterostilbene against fructose-induced accumulation and explored its possible mechanism. We observed high expression microRNA-34a (miR-34a, P < 0.05) low target, sirtuin1 (Sirt1, mRNA: 0.01; protein: 0.001), with overactivation downstream sterol regulatory element-binding protein-1 (SREBP-1)...