A5100753529- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Drug-Induced Ocular Toxicity
- Corneal surgery and disorders
- Photosynthetic Processes and Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Supercapacitor Materials and Fabrication
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Advanced battery technologies research
- Retinopathy of Prematurity Studies
- Protein Tyrosine Phosphatases
- interferon and immune responses
- Cell death mechanisms and regulation
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- Nutrition, Genetics, and Disease
- Analytical Chemistry and Sensors
- Cancer-related Molecular Pathways
- Granular flow and fluidized beds
- Biomarkers in Disease Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Kruppel-like factors research
Harbin Medical University
2024
Taihe Hospital
2018-2022
Hubei University of Medicine
2018-2022
Xi'an Jiaotong University
2022
Union Hospital
2021
Jilin University
2021
China Agricultural University
2012-2017
Liaoning Technical University
2012
Tianjin Children's Hospital
2012
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial mutation with simultaneous or consecutive binocular painless loss of vision and central visual field (VF) defects.1Lam B.L. Feuer W.J. Schiffman J.C. et al.Trial end points natural history in patients G11778A Leber neuropathy: preparation for gene therapy clinical trial.JAMA Ophthalmol. 2014; 132: 428-436Crossref PubMed Scopus (77) Google Scholar In 2008, we initiated recombinant adeno-associated...
Abstract Purpose To analyse the factors associated with rapid and significant improvement in visual acuity patients Leber's hereditary optic neuropathy (LHON) after gene therapy explain theory of this improvement. Methods We recruited 149 LHON, who underwent therapy, divided them into two groups according to absence or presence improvements within 3 days treatment. A bivariate logistic regression model was used relevant including age, period between onset treatment, baseline values best...
The prevalence of obesity has been increasing in the US. Among multifactorial contributors to obesity, dietary factors stand out as primary drivers. Using data from NHANES, we investigated trends and disparities diet quality nutrient intake among US adults with different bodyweight statuses. Participants were divided into normal weight, overweight, obese groups based on BMI. Diet was examined using HEI-2020. Nutrient estimated USDA Food Database for Dietary Studies. From 1999 2020, Despite...
Abstract Importance Factors affecting visual acuity prognosis after gene therapy in Leber's hereditary optic neuropathy (LHON) patients with mutation at site 11 778 are unknown. Background To analyse correlations between and baseline characteristics of LHON rAAV2‐ND4 therapy. Design Retrospective study. Participants Fifty‐three a 778. Methods Single‐eye intravitreal injection rAAV2‐ND4. Main Outcome Measures Sex, onset age, duration disease, best‐corrected (BCVA), field index (VFI) mean...
Background Limited studies have identified the changes in peripapillary retinal nerve fibre layer (pRNFL) thickness patients with chronic Leber’s hereditary optic neuropathy (LHON) at different stages of disease. We aimed to characterise pRNFL LHON having m.11778G>A ( MT-ND4 ) mutation. Methods This retrospective cross-sectional study included 221 eyes from (n=145)—classified into seven groups according disease duration—and 52 healthy controls (n=26). All subjects underwent examinations....
Myocardial infarction (MI) is a major atherosclerotic cardiovascular disease which represents leading cause of death worldwide. Kruppel-like factor 5 (KLF5) member the kruppel-like transcription family has been reported with pro-apoptotic functions in myocardial cells. This work focuses on function KLF5 pathogenesis MI and molecules involved. A mouse model was established. Hypoxia/reoxygenation (H/R)-treated H9C2 cells were applied for vitro experiments. KLF5-specific inhibitor ML264...
Objective To study the characteristics and progression of visual field defects in patients with Leber hereditary optic neuropathy. Design Prospective study. Setting 3-A-class hospital China; single-centre Participants From 100 diagnosed neuropathy, 80 (160 eyes; 68 men 12 women; youngest patient, 6 years; oldest 35 years) were recruited. Exposure All followed up for at least months. Each patient underwent three examinations. Patient groups 1–6 created according to time data acquisition....
Background: Leber's hereditary optic neuropathy is a mitochondrial disease. No effective treatment has so far been established, with gene therapy currently being the most promising. Because of possibility spontaneous visual acuity recovery in this disease, we screened patients before therapy, excluding those improvement, and prepared for subsequent therapy. Objective: To clinically observe course 6 months prior to Methods: Sixty-six were enrolled study. Patients classified based on duration...
During the first few trials of gene therapy for Leber's hereditary optic neuropathy performed by our group, visual acuity patients increased gradually over several months, or even years. However, in current round neuropathy, we noted that three rapidly, within a days after treatment.Three who were diagnosed with mitochondrial 11778 mutation (associated G-to-A transition at Mt-11778 ND4 subunit complex I DNA changes an arginine to histidine amino acid 340) genetic diagnosis followed up times...
To observe the efficacy and safety of pars plana vitrectomy (PPV) combined with filtered air tamponade in treatment rhegmatogenous retinal detachment (RRD) inferior breaks.This retrospective study included 20 patients (20 eyes) breaks RRD; all underwent PPV tamponade. Preoperative examinations BCVA, IOP, anterior segment, fundus locations, numbers, sizes ocular B-mode ultrasonography. Postoperative residual gas volume, reattachment, complications.After follow-up for 1 year, primary...
The yaw rock-breaking processes of roadheader single pick at different positions have been simulated by using LS-DYNA, and the dynamic process that pick-shaped cutters cut hard-rock has analyzed with technique SPH(Smooth Particle Hydrodynamics). It found separating rock into smooth particle hydrodynamics(SPH) units can effectively simulate analyze deformation, damage other phenomena to lay a foundation design, processing failure modes analysis. results calculations show this kind new...
To investigate retinal nerve fiber layer (RNFL) thickness changes at different stages of Leber's hereditary optic neuropathy (LHON) in patients bearing the ND4 G11778A mutation.Ninety-eight clinically diagnosed, G11778A-positive LHON underwent 538 optical coherence tomography (OCT) examinations from September 2015 to 2017. Patients were grouped based on disease duration examination. Fifty healthy volunteers 100 as controls. Differences RNFL compared across groups.During onset with mutation,...
To explore the clinical efficacy of quadruple surgery (anterior segment pars plana vitrectomy + phacoemulsification posterior capsulorhexis intraocular lens (IOL) implantation trabeculectomy) and dual (phacoemulsification IOL to treat medically uncontrolled acute primary angle-closure glaucoma (APACG). The data 44 patients (45 eyes) with APACG treated in Department Ophthalmology Taihe Hospital were retrospectively analyzed. They divided into 2 groups based on surgery. There 20 (20 underwent...
Abstract Purpose: To investigate the changes in posterior corneal elevations (PCEs) circular areas and local points after collagen cross-linking (CXL) for treatment of keratoconus. Methods: Method 1 divided cornea into 0–2, 2–4, 4–6, 6–8 mm regions centering on apex. 2 obtained other 34 PCE values point that were identified nasal, supra-nasal, sub-nasal, superior, inferior, temporal, supra-temporal, sub-temporal sides circle with diameters 2, 4, 6, 8 mm, apex thinnest point. Results: showed...