- Musculoskeletal pain and rehabilitation
- Pediatric Pain Management Techniques
- Mindfulness and Compassion Interventions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Infant Development and Preterm Care
- Childhood Cancer Survivors' Quality of Life
- Psychosomatic Disorders and Their Treatments
- Healthcare professionals’ stress and burnout
- Digital Mental Health Interventions
- Pain Management and Placebo Effect
- COVID-19 and Mental Health
- Health, psychology, and well-being
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Complementary and Alternative Medicine Studies
- Sleep and related disorders
- Behavioral Health and Interventions
- Eating Disorders and Behaviors
- Health Policy Implementation Science
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Opioid Use
- Workplace Health and Well-being
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
Karolinska Institutet
2016-2025
Saint Göran Hospital
2021-2025
Karolinska University Hospital
2012-2024
Stanford University
2021
Aarhus University Hospital
2021
Children's Healthcare of Atlanta
2011
Georgia State University
2011
Uppsala University
2004-2006
Although several studies have illustrated the effectiveness of cognitive behavior therapy (CBT) on adult pain patients, there are few randomized controlled trials children and adolescents. There is particularly a need for pediatric patients who severely disabled by longstanding syndromes. Acceptance Commitment Therapy, as an extension traditional CBT, focuses improving functioning quality life increasing patient's ability to act effectively in concordance with personal values also presence...
Fibromyalgia (FM) is characterized by widespread pain and co-morbid symptoms such as fatigue depression. For FM, medical treatments alone appear insufficient. Recent meta-analyses point to the utility of cognitive behaviour therapy (CBT), but effects are moderate. Within continuous development CBT, empirical support for acceptance commitment (ACT) has increased rapidly. ACT focuses on improving functioning increasing patient's ability act in accordance with personal values also presence...
Interventions based on Cognitive Behavioral Therapy (CBT) are widely used to treat chronic pain, but the brain mechanisms responsible for these treatment effects poorly understood. The aim of this study was validate relevance cortical control theory in response an exposure-based form CBT, Acceptance and Commitment Therapy, patients with pain. Forty-three female diagnosed fibromyalgia syndrome were enrolled a randomized, 12-week, waiting-list controlled clinical trial (CBT n=25; controls...
Abstract Cognitive behavior therapy (CBT) has made important contributions to chronic pain management, but the process by which it is effective not clear. Recently, strong arguments have been raised concerning need for theory driven research e.g. identify mechanisms of change in CBT and enhance effectiveness this type treatment. However, number studies addressing these issues still relatively scarce. Furthermore, arrival varieties with seemingly different targets increases such information....
Although 14% to 42% of people with whiplash injuries end up chronic debilitating pain, there is still a paucity empirically supported treatments for this group patients. In pain management, increasing consensus regarding the importance behavioural medicine approach symptoms and disability. Cognitive behaviour therapy has proven be beneficial in treatment pain. An that promotes acceptance of, or willingness experience, other associated negative private events (e.g. fear, anxiety, fatigue)...
Acceptance of pain and other associated negative private experiences has received increasing attention in recent years. This approach is stark contrast to the traditional reducing or controlling symptoms pain. The empirical support for treatments emphasizing exposure acceptance, such as Commitment Therapy, growing. However, date, few instruments exist assess core processes these types treatments. study describes development preliminary validation Psychological Inflexibility Pain Scale....
For chronic pain of unclear origin (idiopathic), pharmacological therapy is often insufficient. Psychological treatment strategies have been developed and evaluated for adults with pain. However, few such studies are seen youths, to date there limited empirical evidence regarding the effectiveness psychological generalized musculoskeletal syndromes in adolescents. Acceptance commitment (ACT) a development cognitive behaviour emphasizing exposure acceptance. In this pilot study, 14...
Recent developments within CBT have emphasized acceptance rather than control of pain and distress in treatments aimed at improving functioning life quality, but there is still a lack reliable valid instruments to assess relevant processes such interventions. The Psychological Inflexibility Pain Scale (PIPS) was developed target variables exposure oriented treatments. A preliminary validation study resulted two-factor solution with subscales for avoidance cognitive fusion related pain,...
Summary Variables consistent with psychological flexibility mediate the effects of Acceptance and Commitment Therapy-based interventions to improve functioning in patients chronic debilitating pain. Even though are well established treatment pediatric pain, there is a clear need for further development, especially severely disabled patients. However, optimizing effectiveness treatments pain requires clarification mechanisms action. Studies addressing change processes scarce, however,...
Resilience factors have been suggested as key mechanisms in the relation between symptoms and disability among individuals with chronic pain. However, there is a need to better operationalize resilience empirically evaluate its role function. The present study examined psychological flexibility factor functioning 252 adults pain applying for participation digital ACT-based self-help treatment. Participants completed measures of (pain intensity, anxiety), interference depression), well...
Acceptance of pain and distress has lately appeared as an important factor in determining peoples' ability to restore functioning the presence chronic pain. Although treatments based on cognitive behaviour therapy are beginning incorporate acceptance strategies, there is still a lack reliable valid instruments assess relevant processes such interventions. The Chronic Pain Questionnaire (CPAQ) was originally constructed part development oriented treatment approach for patients. A revised...
Pediatric chronic pain is common and can result in substantial long-term disability. Previous studies on acceptance commitment therapy (ACT) have shown promising results improving functioning affected children, but more research still urgently needed. In the current clinical pilot study, we evaluated an ACT-based interdisciplinary outpatient intervention (14 sessions), including a parent support program (four sessions). Adolescents were referred to clinic if they experienced disabling pain....
Symptoms after inflammatory activation, so-called sickness behaviour, overlap with trans-diagnostic complaints. As no self-report questionnaire to assess behaviour exists, we aimed develop such an instrument, the Sickness Questionnaire. Items responsive experimentally induced activation (randomized double-blind study endotoxin (0.6 ng/kg) versus placebo, n = 52) were selected and statistical properties examined in 172 primary care patients. A principal component analysis indicated a...
Fibromyalgia (FM) is a common and disabling chronic pain disorder, for which existing pharmacological psychological treatments have yet yielded insufficient effects. Previous literature has shown that exposure therapy may be an effective treatment pain. This study constitutes the first randomized controlled trial evaluating FM.A total of 140 participants with diagnosed FM were to 10-week Internet-delivered (iExp; n=70) or waitlist control condition (WLC; n=70). Primary outcome measure...
The purpose of the present pilot study was to explore moderating role basal inflammation on effects behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated outcomes: higher pre-treatment levels Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related less improvement intensity, psychological inflexibility mental health-related quality life. outcomes improved subgroup that had low cytokines at baseline, while subjects did not....
Abstract Background Studies of Internet‐delivered acceptance and commitment therapy (ACT) for chronic pain have shown small to moderate positive effects interference acceptance. Effects on intensity, depression, anxiety quality life (QoL) been less favourable, improvements values sleep are lacking. In this randomized controlled trial iACT – a novel format Internet‐ACT using daily microlearning exercises was examined efficacy compared waitlist condition. Methods Adult participants (mean age...
A neuropsychological assessment was conducted to study cognition, with emphasis on memory, information processing/learning ability, and executive functions in boys Duchenne muscular dystrophy (DMD). group of 20 DMD, aged 7 14 years (mean age 9 5 months, SD 2 months), contrasted 17 normally developing age‐matched comparison individuals, using specific tests (Block Span, Digit Story Recall, Rey Auditory Verbal Learning Test, Complex Figure Spatial Fluency, Trail Making Tower London, Memory for...
A neuropsychological assessment was conducted to study cognition, with emphasis on memory, information processing/learning ability, and executive functions in boys Duchenne muscular dystrophy (DMD). group of 20 DMD, aged 7 14 years (mean age 9 5 months, SD 2 months), contrasted 17 normally developing age-matched comparison individuals, using specific tests (Block Span, Digit Story Recall, Rey Auditory Verbal Learning Test, Complex Figure Spatial Fluency, Trail Making Tower London, Memory for...
Acceptance and commitment therapy (ACT) is a promising treatment option for fibromyalgia (FM). Studies have shown that many cognitive behavioral protocols can be transferred to the Internet with sustained efficacy. However, no study has investigated effect on an Internet-delivered ACT-based protocol FM. This evaluated efficacy, acceptability, health economic effects of acceptance values-based exposure FM.This open pilot trial included 41 self-referred women FM diagnosis. The 10-week...