A5023005815- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Mechanisms and Treatments
- Health, psychology, and well-being
- Psychosomatic Disorders and Their Treatments
- Psychology of Moral and Emotional Judgment
- Dermatology and Skin Diseases
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Pediatric Pain Management Techniques
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Optimism, Hope, and Well-being
- Health, Environment, Cognitive Aging
- Optical Imaging and Spectroscopy Techniques
- Exercise and Physiological Responses
- Intensive Care Unit Cognitive Disorders
- Sexual function and dysfunction studies
Karolinska Institutet
2015-2024
University of Stavanger
2021-2024
Stockholm University
2014-2023
Stanford University
2018-2019
Karolinska University Hospital
2012-2017
Observational studies have suggested that with time, some diseases result in a characteristic odor emanating from different sources on the body of sick individual. Evolutionarily, however, it would be more advantageous if innate immune response were detectable by healthy individuals as first line defense against infection various pathogens, to optimize avoidance contagion. We activated system injecting them endotoxin (lipopolysaccharide). Within just few hours, endotoxin-exposed had aversive...
Symptoms after inflammatory activation, so-called sickness behaviour, overlap with trans-diagnostic complaints. As no self-report questionnaire to assess behaviour exists, we aimed develop such an instrument, the Sickness Questionnaire. Items responsive experimentally induced activation (randomized double-blind study endotoxin (0.6 ng/kg) versus placebo, n = 52) were selected and statistical properties examined in 172 primary care patients. A principal component analysis indicated a...
Despite the existing knowledge regarding neuropathology of Alzheimer's disease (AD), cause sporadic forms is unknown. It has been suggested that systemic inflammation may have a role, but exact mechanisms through which inflammatory processes influence pathogenesis and progress AD are not obvious. Allergy chronic affecting more than 20% Western population, effects allergic conditions on brain functions largely The aim this study was to investigate whether or peripheral associated with allergy...
Serotonin (5-HT) is highly involved in pain regulation and serotonin-1A (5-HT1A) receptors are important determining central 5-HT tone. Accordingly, variation the 5-HT1A receptor gene (HTR1A) may contribute to inter-individual differences human sensitivity. The minor G-allele of HTR1A single nucleotide polymorphism (SNP) rs6295 attenuates firing serotonergic neurons reduces postsynaptic expression receptor. Experiments rodents suggest that 5-HT1A-agonism modulates opposite directions at mild...
Severe health anxiety is characterized by a debilitating fear of somatic illness, and avoidance disease-related stimuli plays key role in the maintenance disorder. The aim this study was to investigate severe within an evolutionary disease-avoidance framework. We hypothesized that, compared healthy controls, participants with would perceive others as sicker, more contagious, less attractive. also expected individuals be prone avoid interaction persons who appeared sick, well respond...
The role of inflammation in common psychiatric diseases is now well acknowledged. However, the factors and mechanisms underlying inter-individual variability vulnerability to develop psychopathology-related symptoms response are not characterized. Herein, we aimed at investigating morphological brain regions central for interoception emotion regulation, if these associated with acute inflammation-induced sickness anxiety responses. Systemic was induced using an intravenous injection...
Chronic pain is characterized by high psychological comorbidity, and diagnoses are symptom-based due to a lack of clear pathophysiological factors valid biomarkers. We investigate if inflammatory blood biomarker signatures associated with intensity comorbidity in mixed chronic population. Eighty-one patients (72% women) (>6 months) were included. Patient reported outcomes collected, was analyzed the Proseek Multiplex Olink Inflammation Panel (Bioscience Uppsala, Sweden), resulting 77...
Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in brain, but this hypothesis has not been tested humans. The aim present study was therefore to investigate seasonal changes glial cell marker translocator protein (TSPO), relate peripheral inflammation, fatigue sleep, allergy. We examined 18 patients severe allergy, 13 healthy subjects...
Contagious disease is a major threat to survival, and the cost of relying on immune system defeat pathogens high; therefore, behavioral avoidance contagious individuals arguably an adaptive strategy. Animal findings demonstrate ability detect avoid sick by aid olfactory cues, recent study indicated that human axillary odor also becomes more aversive as function activation. By injecting healthy participants with lipopolysaccharide (0.6 ng/kg body weight) experimentally induce inflammation,...
Chronic sickness behavior is implicated in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) and chronic pain but the level of subjective these conditions has not been investigated or compared to other clinical non-clinical samples, experimental inflammation. Furthermore, relationship between self-rated health functioning known patients with pain. The aim present study was investigate how differs from that individuals acute sickness, primary care patients, general population...
Background Patient-reported outcomes predict mortality and play increasingly important roles in care, but factors that modify central measures such as health ratings have been little investigated. Building on designated immune-to-brain pathways, we aimed to determine how a short-term induced inflammation response impacts self-reported status. Methods Lipopolysaccharide injections were used provoke acute systemic inflammatory responses healthy men women compared placebo two double-blind...
Approximately one in five adults experiences chronic pain, often co-occurrence with depression, insomnia, anxiety, and lower self-rated health. Elevated levels of cytokines, e.g. tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), 8 (IL-8), 10 (IL-10), have been identified patients pain. Depression, insufficient sleep, poor health, pain intensity also associated inflammatory biomarkers. This study aimed to investigate the interrelationships between biomarkers sickness behavior,...
Background: Low-grade inflammation has been implicated in the etiology of depression, long-term fatigue and chronic pain. TNFα IL-6 are perhaps most studied pro-inflammatory cytokines field psychoneuroimmunology. The purpose our study was to further investigate these relationships patients with pelvic pain specifically. Using plasma samples from a large, well-described cohort healthy controls via Multidisciplinary Approach Study Chronic Pelvic Pain (MAPP) Research Network, we examined...