A5077822527- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Aldose Reductase and Taurine
- Immune Response and Inflammation
- Urinary Tract Infections Management
- Escherichia coli research studies
- Prenatal Substance Exposure Effects
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Treatment of Major Depression
- Schizophrenia research and treatment
- Pneumonia and Respiratory Infections
- T-cell and B-cell Immunology
- Functional Brain Connectivity Studies
- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Monoclonal and Polyclonal Antibodies Research
- Psychosomatic Disorders and Their Treatments
- Electrolyte and hormonal disorders
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Immunodeficiency and Autoimmune Disorders
- Immune cells in cancer
- Structural Engineering and Materials Analysis
Linköping University
2011-2024
Linköping University Hospital
2024
Region Östergötland
2018-2022
County Administrative Board
2018-2022
Karolinska Institutet
2010-2016
Karolinska University Hospital
2011-2015
Science for Life Laboratory
2015
AstraZeneca (Sweden)
2015
Lund University
2001-2014
University of Gothenburg
2010-2011
The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. an endogenous metabolite tryptophan (TRP) produced astrocytes and antagonizes N-methyl-D-aspartate α7* nicotinic receptors. formation determined by the availability substrate, hence, we analyzed its precursors, kynurenine (KYN) TRP, cerebrospinal fluid (CSF) patients with schizophrenia. CSF from male olanzapine treatment (n = 16) was compared healthy...
Accumulating evidence indicates that schizophrenia is associated with brain immune activation. While a number of reports suggest increased cytokine levels in patients schizophrenia, many these studies have been limited by their focus on peripheral cytokines or confounded various antipsychotic treatments. Here, well-characterized all receiving olanzapine treatment, and healthy volunteers were analyzed regard to cerebrospinal fluid (CSF) cytokines. We correlated the CSF previously metabolites...
Considerable data relate major depressive disorder (MDD) with aberrant immune system functioning. Pro-inflammatory cytokines facilitate metabolism of tryptophan along the kynurenine pathway (KP) putatively resulting in reduced neuroprotective and increased neurotoxic KP metabolites MDD, addition to modulating metabolic function. This central nervous hypothesis has, however, only been tested periphery. Here, we measured KP-metabolite levels both plasma cerebrospinal fluid (CSF) depressed...
<h3>Background:</h3> In recent years, a role for the immune system in pathogenesis of psychiatric diseases has gained increased attention. Although bipolar disorder appears to be associated with altered serum cytokine levels, putative immunological contribution its patho-physiology remains established. Hitherto, no direct analyses cerebrospinal fluid (CSF) cytokines patients have been performed. <h3>Methods:</h3> We analyzed CSF concentrations euthymic diagnosed type I (<i>n</i> = 15) or II...
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels schizophrenia result from pathological shift kynurenine pathway toward enhanced formation, away other branch leading to quinolinic (QUIN). Here we investigate QUIN cerebrospinal fluid (CSF) patients with and healthy controls, relate those CSF metabolites same individuals. stable outpatients treated olanzapine (n = 22) controls 26) were...
Neuroinflammation is increasingly recognized as contributing to the pathogenesis of depression. Key inflammatory markers well kynurenic acid (KYNA) and quinolinic (QUIN), both tryptophan metabolites, have been associated with depressive symptoms suicidality. The aim present study investigate peripheral concentration cytokines kynurenine metabolites in patients unipolar treatment-resistant depression before after electroconvulsive therapy (ECT), most effective treatment for Cytokines plasma...
Neutrophil migration to infected mucosal sites involves a series of complex interactions with molecules in the lamina propria and at epithelial barrier. Much attention has focussed on vascular compartment endothelial cells, but less is known about molecular determinants neutrophil behavior periphery. We have studied urinary tract infections (UTIs) determine events that initiate recruitment recruited neutrophils Bacteria activate chemokine response uroepithelial repertoire depends bacterial...
Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls mucosal response Escherichia coli urinary tract infections. Inactivation of mouse causes an asymptomatic carrier state resembling bacteriuria (ABU). The present study compared neutrophil levels between children ABU (n=17) and age-matched control subjects (n=24), significantly...
BackgroundFor unknown reasons, urinary tract infections (UTIs) are clustered in certain individuals. Here we propose a novel, genetically determined cause of susceptibility to acute pyelonephritis, which is the most severe form UTI. The IL-8 receptor, CXCR1, was identified as candidate gene when mIL-8Rh mutant mice developed pyelonephritis (APN) with tissue damage.Methods and FindingsWe have obtained CXCR1 sequences from two, highly selected APN prone patient groups, detected three unique...
<h3>Background:</h3> Patients with schizophrenia show elevated brain levels of the neuroactive tryptophan metabolite kynurenic acid (KYNA). This astrocyte-derived mediator acts as a neuroprotectant and modulates sensory gating cognitive function. We measured KYNA in cerebrospinal fluid (CSF) patients bipolar disorder healthy volunteers to investigate putative involvement disorder. <h3>Methods:</h3> obtained CSF by lumbar puncture from 23 men 31 euthymic analyzed samples using...
Objective Recent studies indicate that inflammation may play a role in the pathophysiology of suicidality. Interleukin‐8 ( IL ‐8) is chemokine addition to its function immune system also exert neuroprotective properties. The involvement this neuropsychiatric conditions incompletely known. Method We measured plasma and cerebrospinal fluid CSF ) ‐8, as well genotype frequency single nucleotide polymorphism (‐251A/T, rs4073) promoter region 8 gene, suicide attempters n = 206) healthy controls...
A coherent sense of self is crucial for social functioning and mental health. The N-methyl-D-aspartate antagonist ketamine induces short-term dissociative experiences has therefore been used to model an altered state self-perception. This randomized double-blind placebo-controlled cross-over study investigated the mechanisms ketamine's effects on bodily in context affective touch. Thirty healthy participants (15 females/15 males, age 19-39) received intravenous or placebo while performing...
Mucosal pathogens differ from normal flora constituents in that they provoke a host response upsets mucosal integrity. We investigated whether the elaboration of discrete adherence factors is sufficient to break inertia barrier. PapG-mediated was selected as an example, because P fimbrial expression characterizes uropathogenic Escherichia coli and starts attack on Patients were inoculated intravesically with transformed nonvirulent E. strains expressing functional fimbriae (E. pap(+)) or...
In recent years, kynurenine metabolites generated by tryptophan catabolism have gained increasing attention in the context of brain diseases. The question importance is whether there a relationship between peripheral and central levels these metabolites. Some compounds do not cross blood-brain barrier; particular, kynurenic acid, most analyses kynurenines from psychiatric patients been performed using plasma samples. present study, we recruited 30 healthy volunteers with no history or...