A5002326847- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Nanoparticle-Based Drug Delivery
- Cardiac Imaging and Diagnostics
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Parkinson's Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Aortic Thrombus and Embolism
- Nutrition and Health in Aging
- RNA modifications and cancer
- Neurological disorders and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- HIV-related health complications and treatments
- Nanoplatforms for cancer theranostics
- Inflammasome and immune disorders
- MRI in cancer diagnosis
- Coronary Interventions and Diagnostics
Medical University of Graz
2014-2025
Vienna BioCenter Core Facilities
2018
Vienna Biocenter
2018
Graz University of Technology
2009-2012
Obesity is characterized by excessive adipose tissue mass and associated with type 2 diabetes cardiovascular diseases. To fight obesity its sequels, elucidating molecular events that govern adipocyte differentiation function of key importance. MicroRNAs (miRNAs) are a novel class non-coding, regulatory RNAs have been shown to regulate crucial cellular processes, including differentiation. Several studies already assigned miRNAs distinct functions in murine but only few did so for...
The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies. Here we performed a large diffusion MRI study PD, integrating data from 17 cohorts worldwide, identify stage-specific profiles white matter differences. Diffusion-weighted 1654 participants diagnosed PD (age: 20–89 years; 33% female) 885...
Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They applied as contrast agents for resonance imaging (MRI). MLs have an advantage over free nanocores, in various functional groups can be attached to the surface of ligand-specific targeting. We synthesized PEG-coated sterically-stabilized (sMLs) containing ultrasmall superparamagnetic iron oxides (USPIOs) with aim generating stable liposomal carriers equipped a high payload...
Abstract Background Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non‐motor functioning remain be elucidated. Objective To quantify cross‐sectional lobule volumes using three dimensional T1‐weighted anatomical brain magnetic resonance imaging from global ENIGMA‐PD working group. Methods Cerebellar parcellation was performed deep learning‐based approach 2487 people PD 1212...
Diffusion weighted (DW) cardiovascular magnetic resonance (CMR) has shown great potential to discriminate between healthy and diseased vessel tissue by evaluating the apparent diffusion coefficient (ADC) along arterial axis. Recently, ex vivo studies on porcine arteries utilizing tensor imaging (DTI) revealed a circumferential fiber orientation rather than an organization in axial direction, suggesting dominant perpendicular slice direction. In present study, we propose method access...
Abstract Background The progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies, particularly regarding involvement white matter (WM) tracts. Here we performed largest diffusion MRI study PD date, integrating data from 17 cohorts worldwide, identify stage-specific profiles WM differences. Methods...
Atherosclerosis, the leading cause of cardiovascular disease, cannot be sufficiently explained by established risk factors, including cholesterol. Elevated plasma homocysteine (Hcy) is an independent factor for atherosclerosis and closely linked to mortality. However, its role in has not been fully clarified yet. We have previously shown that rabbits fed a diet deficient B vitamins choline (VCDD), which are required Hcy degradation, exhibit accumulation macrophages lipids aorta, aortic...
Short-term effects of alirocumab on vascular function have hardly been investigated. Moreover, there is a scarce reliable non-invasive methods to evaluate atherosclerotic changes the vasculature. The ALIROCKS trial was performed address these issues using standard ultrasound-based procedures and completely novel magnetic resonance-based imaging technique.A total 24 patients with an indication for treatment PCSK9 antibodies were recruited. There 2 visits study site, first before initiation...
Functional brain alterations in post-Covid-19 condition have been minimally explored to date. Here, we investigate differences resting-state thalamic functional connectivity among post-Covid patients with and without fatigue, alongside structural changes cognition.
Atherosclerosis, the leading cause of cardiovascular disease responsible for majority deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma homocysteine is an independent factor atherosclerosis and strongly linked to mortality. However, role in still insufficiently understood. Previous research this area has been also hampered lack reproducible vivo models that resemble human situation. Here, we have developed applied...
Abstract Nanomedicine, a young and innovative field, offers interesting approaches for diagnosis treatment in personalized medicine. Myocardial infarction stroke belong to the most important challenges this context because an improved early of individuals well before fatal clinical endpoints occur is urgently needed. The underlying cause myocardial atherosclerosis, chronic immune-mediated inflammation vascular wall involving monocytes, macrophages, T-lymphocytes, arterial cells. Hence,...
Abstract Atherosclerosis, the leading cause of cardiovascular disease, cannot be sufficiently explained by established risk factors such as cholesterol. Elevated plasma homocysteine (Hcy) is an independent factor for atherosclerosis and closely linked to mortality. However, its role in has not been fully clarified. We have previously shown that rabbits fed a diet deficient B vitamins choline (VCDD), required Hcy degradation, exhibit accumulation macrophages lipids aorta, impairment...