A5035498713- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Hemophilia Treatment and Research
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Blood properties and coagulation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- Diabetes and associated disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atrial Fibrillation Management and Outcomes
- Blood groups and transfusion
- Obesity, Physical Activity, Diet
Medical University of Graz
2016-2025
University of Graz
2000-2020
Medizinische Hochschule Hannover
2016
European Space Agency
2015
Johns Hopkins Medicine
2009
Johns Hopkins University
2009
Austrian Agency for Health and Food Safety
2009
Johannes Gutenberg University Mainz
2007
Landeskrankenhaus Feldkirch
2005
Universitätsklinik für Kinder und Jugendpsychiatrie
2002-2005
<i>Background:</i> The tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic measurement to assess right ventricular function in adults and children. <i>Objective:</i> We determined growth- birth weight-related changes of TAPSE establish reference values preterm term neonates. <i>Methods:</i> A prospective study was conducted a group 258 neonates (age: 25+0 40+6 weeks gestation, weight: 530–4,200 g). <i>Results:</i> ranged...
Albumin is the most abundant plasma protein. Critical illness often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia usually corrected by administration of exogenous albumin. study aimed to track concentration-dependent influence on blood coagulation in vitro. Whole (WB) samples from 25 volunteers were prepared contain low (19.3 ± 7.7 g/L), physiological (45.2 7.8 and high (67.5 18.1 g/L) levels Haemostatic profiling was performed using a platelet...
Abstract Aims To investigate the seroconversion following first and second COVID‐19 vaccination in people with type 1 2 diabetes relation to glycaemic control prior analyse response comparison individuals without diabetes. Materials methods This prospective, multicentre cohort study analysed a glycated haemoglobin level ≤58 mmol/mol (7.5%) or >58 (7.5%), respectively, healthy controls. Roche's Elecsys anti‐SARS‐CoV‐2 S immunoassay targeting receptor‐binding domain was used quantify...
Pulsed-wave Doppler determination of the pulmonary artery acceleration time (PAAT) as a surrogate for pressure was found to be clinical value assessment hypertension (PH) with studies date exclusively performed in adults. This study aims provide representative, normal reference values PAAT children all ages. Moreover, we validated abnormal 54 PH.We conducted prospective echocardiographic 756 healthy (aged 1 day 18 years) and PH. Possible associations age, body length, weight, surface area,...
The tricuspid annular plane systolic excursion (TAPSE), as echocardiographic index to assess right ventricular (RV) function, has not been investigated thoroughly in children and young adults with tetralogy of Fallot (TOF) pulmonary artery hypertension secondary congenital heart disease (PAH-CHD). TAPSE values 49 patients PAH-CHD 156 TOF were compared age-matched normal subjects. also RV ejection fraction (RVEF) indexed end-diastolic volume (RVEDVi) determined by magnetic resonance imaging...
Iron oxide nanoparticles (IONs) are of great interest in nanomedicine for imaging, drug delivery, or hyperthermia treatment. Although many research groups have focused on the synthesis and application IONs nanomedicine, little is known about influence surface properties particles' behavior human body. This study analyzes impact coatings (dextran, polyvinyl alcohol, polylactide-co-glycolide) nanoparticles' cytocompatibility, agglomeration, degradation, resulting oxidative stress induced by...
The vitamin B complex comprises 8 different water-soluble constituents that humans must sequester from the diet. This pilot study compared natural versus synthetic complexes for their bioavailability, accumulation, and impact on antioxidants, homocysteine levels, oxidative stress. We conducted a double-blind randomized clinical trial with thirty healthy participants. They were randomly assigned to group N (natural) S (synthetic). Vitamin was ingested daily 6 weeks in range of about 2.5 times...
Coated iron oxide nanoparticles (IONs) are promising candidates for various applications in nanomedicine, including imaging, magnetic hyperthermia, and drug delivery. The application of IONs nanomedicine is influenced by factors such as biocompatibility, surface properties, agglomeration, degradation behavior, thrombogenicity. Therefore, it essential to investigate the effects coating material thickness on behavior performance human body. In this study, with a carboxymethyl dextran (CMD) two...
Abstract Available evidence suggests that various medical/rehabilitation treatments evoke multiple effects on blood hemostasis. It was therefore the aim of our study to examine whether fascial manipulation, vibration exercise, motor imagery, or neuro‐muscular electrical stimulation can activate coagulation system, and, thereby, expose patients thrombotic risk. Ten healthy young subject were enrolled in study. Blood samples obtained pre and posttreatment. Besides standard laboratory methods,...
Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis. In our vitro-model, oxidation was induced by the addition CuCl2 presence increasing concentrations degree lipid, as well protein part LDL, measured. We found that spermidine concentration-dependently inhibited production lipid hydroperoxides, malondialdehyde,...
During human placentation extravillous trophoblasts (EVTs), arising from cell column (CCT) invade the highly differentiated uterine mucosa, called decidua, where they erode blood vessels and replace vascular endothelial cells. Maternal platelets have been detected in intercellular gaps of CCTs but their physiological role remained unclear so far. This study aimed to elucidate impact platelet-derived factors on that are exposed maternal through erosion decidual vessels. Trophoblast line...
Although there is no direct evidence, it generally believed that bed rest shifts the haemostatic system towards hypercoagulability; thus, immobilized patients are commonly treated with anticoagulants. We therefore aimed to investigate whether long-term actually leads an elevated risk for thromboembolic events.Eleven healthy men were enrolled in our study (bed campaign MEDES Clinique d'Investigation, Toulouse, France). Besides various standard laboratory methods, we used calibrated automated...
Abstract Objective Extremely low gestational age newborns (ELGANs) represent an especially vulnerable population. Herein, we aimed to determine incidence and severity of pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH) in extremely immature ELGANs (gestational age: 23 0/6 –25 6/7 weeks). Methods In this prospective observational cohort study, assessed BPD-PH by means several echocardiography markers serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels...
Summary Recombinant factor VIIa (rVIIa) has been reported to be clinically effective and safe in haemophilic patients with inhibitor antibodies. Compared activated prothrombin complex concentrates the risk of thrombotic complications seems very low after rVIIa administration. Determination free thrombin generation shown identify hypercoagulability. Therefore, prothrombinase activity (Xa generation) were assessed extrinsic activation supplemented VIII IX deficient plasma. Free was also...
Obesity is associated with increased prevalence of thromboembolic events. We aimed to investigate whether obese women might benefit from vigorous aerobic exercise. Forty-two overweight and performed a 30-min walking exercise test (treadmill ergometer) at an intensity 70% individual peak oxygen uptake. Blood samples were collected before immediately after Thrombelastometry platelet function measurements on whole blood. Standard coagulation times, thrombin generation curves, markers...