A5080211352- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Balance, Gait, and Falls Prevention
- Nuclear Receptors and Signaling
- Heart Rate Variability and Autonomic Control
- Assistive Technology in Communication and Mobility
- RNA regulation and disease
- Studies on Chitinases and Chitosanases
- Botulinum Toxin and Related Neurological Disorders
- Advanced Sensor and Energy Harvesting Materials
Fondazione Santa Lucia
2013-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2021
Sapienza University of Rome
2012
Freezing of Gait (FoG) is a common symptom in Parkinson’s Disease (PD) occurring with significant variability and severity associated increased risk falls. FoG detection everyday life not trivial, particularly patients manifesting the only specific conditions. Various wearable devices have been proposed to detect PD symptoms, primarily based on inertial sensors. We here report results validation novel system pair pressure insoles equipped 3D accelerometer episodes. Twenty attended motor...
Background Mobile health, predominantly wearable technology and mobile apps, have been considered in Parkinson disease to provide valuable ecological data between face-to-face visits improve monitoring of motor symptoms remotely. Objective We explored the feasibility using a technology-based mHealth platform comprising smartphone combination with smartwatch pair smart insoles, described this study as PD_manager system, collect clinically meaningful data. also outcomes disease-related factors...
Rapid eye movement (REM) sleep behavior disorder (RBD) is a risk factor for developing Parkinson’s disease (PD) and may represent its prodromal state. We compared neuropsychological neuropsychiatric phenotypes of idiopathic (i) RBD, PD healthy comparators (HC) in order to identify iRBD specific characteristics. Thirty-eight patients with iRBD, 38 RBD (PD + RBD), without (PD-RBD) HC underwent comprehensive neurological, evaluation. PD-RBD performed worse than short-term verbal memory, praxia,...
The present study investigated the association of SNPs involved in regulation immune response, cellular degenerative and neuroinflammatory pathways with susceptibility progression idiopathic Parkinson’s Disease (PD). In particular, 342 PD patients were subjected to a genotyping analysis panel 120 by Open Array Technology. As control group, 503 samples representative European general population utilized. genetic identified 26 associated susceptibility. Of them, 12 described as significant...
Phenotypic variants of progressive supranuclear palsy (PSP) are all characterized by the combination motor symptoms parkinsonism with a number neuropsychiatric and cognitive disorders. Despite strong effort in characterizing these features PSP, alexithymia anhedonia have not been investigated at present. Here, we aimed investigating qualitative quantitative differences two more frequent Richardson's syndrome (PSP-RS) PSP predominant (PSP-P) compared to Parkinson's disease (PD) patients...
Memory processes are based on large cortical networks characterized by non-stationary properties and time scales which represent a limitation to the traditional connectivity estimation methods. The recent development of approaches able consistently describe temporal evolution dimension networks, in fully multivariate way, represents tool that can be used extract novel information about at basis memory functions. In this paper, we applied such advanced approach combination with use...
Episodes of complete failure to respond during attentive tasks — lapses responsiveness ('lapses') accompanied by behavioral signs sleep such as slow-eye-closure are known microsleeps (BMs). The occurrence BMs can have serious/fatal consequences, particularly in the transport sectors, and therefore further investigations on neurophysiological correlates highly desirable. In this paper we propose a combination High Resolution EEG techniques an advanced method for time-varying functional...
<sec> <title>BACKGROUND</title> Mobile health, predominantly wearable technology and mobile apps, have been considered in Parkinson disease to provide valuable ecological data between face-to-face visits improve monitoring of motor symptoms remotely. </sec> <title>OBJECTIVE</title> We explored the feasibility using a technology-based mHealth platform comprising smartphone combination with smartwatch pair smart insoles, described this study as PD_manager system, collect clinically meaningful...