A5025268881- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Head and Neck Surgical Oncology
- Pregnancy and preeclampsia studies
- Spinal Dysraphism and Malformations
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Complement system in diseases
- Primary Care and Health Outcomes
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Face Recognition and Perception
- Healthcare Policy and Management
- Hospital Admissions and Outcomes
- Neonatal and fetal brain pathology
Yale New Haven Hospital
2023-2024
Yale University
2022-2023
The University of Texas at Dallas
2018-2022
Background: Cognitive slowing occurs in ~70% of multiple sclerosis (MS) patients. The pathophysiology this is unknown. Neurovascular coupling, acute localized blood flow increases following neural activity, essential for efficient cognition. Loss vascular compliance along the cerebrovascular tree would result suboptimal vasodilation, neurovascular uncoupling, and cognitive slowing. Objective: To assess its relationship to MS-related Methods: We tested by dividing cerebral cortex into nested...
ABSTRACT BACKGROUND AND PURPOSE Multiple sclerosis (MS) clinical management is based upon lesion characterization from 2‐dimensional (2D) magnetic resonance imaging (MRI) views. Such views fail to convey the lesion‐phenotype (ie, shape and surface texture) complexity, underlying metabolic alterations, remyelination potential. We utilized a 3‐dimensional (3D) phenotyping approach coupled with study physiologic profiles within around MS lesions their impacts on phenotypes. METHODS Lesions were...
Neural-vascular coupling (NVC) is the process by which oxygen and nutrients are delivered to metabolically active neurons blood vessels. Murine models of NVC disruption have revealed its critical role in healthy neural function. We hypothesized that, humans, aging exerts detrimental effects upon integrity neural-glial-vascular system that underlies NVC. To test this hypothesis, calibrated functional magnetic resonance imaging (cfMRI) was used characterize age-related changes cerebral flow...
Behavioral studies investigating fundamental cognitive abilities provide evidence that processing speed accounts for large proportions of performance variability between individuals. Processing decline is a hallmark feature the disruption observed in healthy aging and demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optica, Wilson's disease. Despite wealth suggesting central role decline, neural mechanisms this ability remain unknown. Intact neurovascular coupling, acute...
The neural mechanisms underlying motor impairment in multiple sclerosis (MS) remain unknown. Motor cortex dysfunction is implicated blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies, but the role of neural–vascular coupling BOLD changes remains We sought to independently measure physiologic factors (i.e., cerebral blood flow (ΔCBF), metabolic rate oxygen (ΔCMRO 2 ), and flow–metabolism (ΔCBF/ΔCMRO utilizing dual-echo calibrated fMRI (cfMRI) during a...
Facial recognition ability declines in adult aging, but the neural basis for this decline remains unknown. Cortical areas involved face exhibit lower dopamine (DA) receptor availability and blood-oxygen-level-dependent (BOLD) signal during task performance with advancing age. We hypothesized that changes relationship between these two systems are related to age differences face-recognition ability. To test hypothesis, we leveraged positron emission tomography (PET) functional magnetic...
Introduction: Medical education systems are trained to produce efficient, thorough clinicians. These programs provide limited training on personal finances. The current socioeconomic climate for medical trainees includes increasing debt and stagnating reimbursement. We conducted a survey-based cross-sectional pilot study at an academic institution targeted residents, fellows, attendings of all specialties. Our aim was understand baseline levels financial literacy different career stages,...
To explore how age and sex affect cerebrospinal fluid (CSF) dynamics, particularly examining the relationships between CSF production, meningeal lymphatic vessel (mLV) characteristics, glymphatic function. determine impact of brain function on processing speed cognitive performance.
Motivation: Multiple sclerosis (MS) involves a proinflammatory state leading to cellular waste accumulation and disability. This study investigates the glymphatic system's clearance role, hypothesizing that lymphatic dysfunction contributes MS-related Goal(s): Explore relationship between function, meningeal vessels (mLV), Approach: The examined 49 MS patients using MRI visualize mLVs evaluate stasis via CSF fraction (CSFF), analyzing links mLV volume, CSFF, outcomesResults: With age,...