A5028194059- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Schizophrenia research and treatment
- Nicotinic Acetylcholine Receptors Study
- S100 Proteins and Annexins
- Ion channel regulation and function
- Restraint-Related Deaths
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Psychosomatic Disorders and Their Treatments
- Neuroscience of respiration and sleep
- Traumatic Ocular and Foreign Body Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Gun Ownership and Violence Research
- Suicide and Self-Harm Studies
- Homicide, Infanticide, and Child Abuse
- Autopsy Techniques and Outcomes
- Immune Response and Inflammation
- Neural dynamics and brain function
Otto-von-Guericke University Magdeburg
2012-2025
Gdańsk Medical University
2014-2025
University of Gdańsk
2024
University Hospital Magdeburg
2008-2023
Klinikum Magdeburg
2009
Zero to Three
2007
Immune dysfunction, including monocytosis and increased blood levels of interleukin-1, interleukin-6 tumour necrosis factor α has been observed during acute episodes major depression. These peripheral immune processes may be accompanied by microglial activation in subregions the anterior cingulate cortex where depression-associated alterations glutamatergic neurotransmission have described. Microglial immunoreactivity N-methyl-D-aspartate (NMDA) glutamate receptor agonist quinolinic acid...
Alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology mood disorders. Gamma-aminobutyric acid (GABA) acts via binding A and B receptors, whereas receptor is G protein-coupled. Glutamic decarboxylase (GAD) key enzyme GABA synthesis. Immunohistochemical staining GAD 65/67-immunoreactive neurons was performed dorsolateral prefrontal cortex, orbitofrontal anterior cingulate superior temporal hippocampus formation, mediodorsal thalamus with...
An involvement of the central serotonergic system has constantly been reported in pathogenesis suicide. The dorsal raphe nucleus (DRN) is main source innervation forebrain limbic structures disturbed suicidal behaviour, which an abnormal microglia reaction seems to play a role. In our present study, density immunostained for HLA-DR antigen was evaluated DRN. These analyses were carried out on paraffin-embedded brains from 24 and 21 non-suicidal patients; among them, 27 depressed (15 major...
Fetal and neonatal brain development is characterized by developmental time windows during which regions or neuron types are specifically sensitive to environmental influences. Previous studies on cortical have revealed evidence for the hypothesis that extent direction of experience-induced neuronal synaptic changes correlate with endocrine development. To further test this we exposed rats separation stress different phases maturation, i.e. prior, after hyporesponsive period (SHRP)...
In recent years, the hypothalamus, amygdala and hippocampus have attracted increased interest with regard to effects of stress on neurobiological systems in individuals depression suicidal behaviour. A large body evidence indicates that these subcortical regions are involved pathogenetic mechanisms mood disorders suicide. The current neuroimaging techniques inadequately resolve structural components small complex brain structures. previous studies, our group was able demonstrate a neuronal...