A5101496994- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Neural dynamics and brain function
- Animal Vocal Communication and Behavior
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Human-Animal Interaction Studies
- Biochemical Analysis and Sensing Techniques
- Primate Behavior and Ecology
- Attention Deficit Hyperactivity Disorder
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Maternal Mental Health During Pregnancy and Postpartum
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Evolutionary Psychology and Human Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
Otto-von-Guericke University Magdeburg
2015-2024
Center for Behavioral Brain Sciences
2014-2024
Environment Agency Austria
2024
Goethe University Frankfurt
2021
Universität Ulm
2018-2020
Fraunhofer Project Centre Wolfsburg
2020
University Hospital Magdeburg
2016
University of Münster
2012
Weizmann Institute of Science
2006-2008
Leibniz Institute for Neurobiology
1997-2006
Plastic products contain complex mixtures of extractable chemicals that can be toxic. However, humans and wildlife will only exposed to plastic are released under realistic conditions. Thus, we investigated the toxicological chemical profiles leaching into water from 24 everyday covering eight polymer types. We performed migration experiments over 10 days at 40 °C analyzed migrates using four in vitro bioassays nontarget high-resolution mass spectrometry (UPLC-QTOF-MSE). All induced baseline...
Abstract Both chronic stress in adulthood and episodes of the early postnatal period have been shown to interfere with neuronal development limbic prefrontal cortical regions. The present study rats showed for first time that layer II/III pyramidal neurons dorsal anterior cingulate (ACd) orbitofrontal cortex (OFC) is significantly affected offspring mothers exposed during pregnancy. In prenatally stressed (PS) male rat pups ACd OFC lower spine densities on apical dendrite (ACd, −20%; OFC,...
The common neurotransmitter serotonin controls different aspects of early neuronal differentiation, although the underlying mechanisms are poorly understood. Here we report that activation 5-HT 7 receptor promotes synaptogenesis and enhances synaptic activity in hippocampal neurons at postnatal stages. An analysis Gα 12 -deficient mice reveals a critical role G -protein for receptor-mediated effects neurons. In organotypic preparations from hippocampus juvenile mice, stimulation R/G...
The present study provides evidence for the hypothesis that extent and direction of experience-induced synaptic changes in cortical areas correlates with time windows neuronal as well endocrine development. Repeated brief exposure to maternal separation prior stress hyporesponsive period (SHRP) hypothalamic-pituitary-adrenal (HPA) axis induced significantly reduced dendritic spine density (−16%) layer II/III pyramidal neurons anterior cingulate cortex (ACd) 21-day-old rats, whereas after...
Abstract Early life stress (ELS) programs the developing organism and influences development of brain behavior. We tested hypothesis that ELS‐induced histone acetylations might alter expression synaptic plasticity genes are critically involved in establishment limbic circuits. Maternal separation (MS) from postnatal day 14–16 was applied as ELS two immediate early underlying experience‐induced plasticity, Arc growth response 1 (Egr1) were analyzed. show here repeated induces a rapid increase...
Auditory filial imprinting in the domestic chicken is accompanied by a dramatic loss of spine synapses two higher associative forebrain areas, mediorostral neostriatum/hyperstriatum ventrale (MNH) and dorsocaudal neostriatum (Ndc). The cellular mechanisms that underlie this learning-induced synaptic reorganization are unclear. We found local pharmacological blockade N -methyl- d -aspartate (NMDA) receptors MNH, manipulation has been shown previously to impair auditory imprinting, suppresses...
A quantitative anatomical study in the rodent anterior cingulate and somatosensory cortex, hippocampus, lateral amygdala revealed region-, cell-, dendrite-specific changes of spine densities 3-week-old Octodon degus after repeated parental separation. In parentally separated animals significantly higher were found on apical basal dendrites cortex (up to 143% 138% dendrite). Branching order analysis that this effect is seen all segments dendrite, whereas only outer branches (third fifth...
Adequate pain sensitivity requires a delicate balance between excitation and inhibition in the dorsal horn of spinal cord. This is severely impaired neuropathy leading to enhanced sensations (hyperalgesia). The underlying mechanisms remain elusive. Here we explored hypothesis that excitatory drive GABAergic neurons might be neuropathic animals. Transgenic adult mice expressing EGFP under promoter for GAD67 underwent either chronic constriction injury sciatic nerve or sham surgery. In...