A5033942828- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Hematological disorders and diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Breast Cancer Treatment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Head and Neck Cancer Studies
- COVID-19 Clinical Research Studies
- Insects and Parasite Interactions
- Breast Lesions and Carcinomas
- Histiocytic Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Ultrasound and Hyperthermia Applications
- Lung Cancer Diagnosis and Treatment
- Gender Politics and Representation
- Glioma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Pancreatic and Hepatic Oncology Research
Motilal Nehru National Institute of Technology
2024
University of Münster
2022
University of Miami
2019-2022
Boston University
2020-2021
College of Applied Sciences, Nizwa
2020
Chirayu Medical College & Hospital
2016-2018
Constructor University
2015
Jawaharlal Nehru University
2012-2015
King Edward Memorial Hospital and Seth G.S. Medical College
2011-2013
Tata Memorial Hospital
2013
As cells encounter adverse environmental conditions, such as hypoxia, oxidative stress or nutrient deprivation, they trigger response pathways to protect themselves until transient stresses have passed. Inhibition of translation is a key component cellular responses and mounting evidence has revealed the importance class tRNA-derived small RNAs called tiRNAs in this process. The most potent these are those with capability assembling into tetrameric G-quadruplex (G4) structures. However,...
The production of ribosomes is an energy-intensive process owing to the intricacy these massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins and four non-coding RNAs. Accurate assembly requires precise regulation protein RNA subunits. In response stress, integrated stress (ISR) rapidly inhibits global translation. How rRNA coordinately regulated with rapid inhibition synthesis not known. Here, we show that specifically first step processing. Unprocessed stored...
DEAD-box proteins (DBPs) are RNA remodeling factors associated with helicase activity that found in nearly all organisms. Despite extensive studies on the mechanisms used by DBPs to regulate function, very little is known about how themselves regulated. In this work, we have analyzed expression and regulation of DeaD/CsdA, largest Escherichia coli ( E. ). We show deaD transcription initiates 838 nt upstream start coding region. also DeaD autoregulated through a negative feedback mechanism...
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising from follicular cells of germinal centers. The most common site origin lymph nodes and it may mimic variety tumors at that location, including carcinomas sarcomas. Diagnosis frequently missed on cytology as there are very few case reports describing the cytological characteristics lesion. Even histology, high degree suspicion required for an appropriate diagnosis.A 60-year-old male presented with gradually increasing left...
<i>Background:</i> Infantile digital fibromatosis (IDF) or inclusion body is a benign proliferation of fibroblastic and myofibroblastic cells. Its most common site the digits young children it named for intracytoplasmic inclusions that are detected in lesional <i>Case:</i> A two half-year-old male child presented with single flesh-colored nodule on dorsal aspect his right little toe since sixth month life. FNAC from lesion showed characteristic cytomorphological...
A 55-year-old female presented to outpatient department with complaints of left flank pain, vomiting and abdominal fullness.CT scan revealed a large mass at lower pole kidney which appeared arise from renal parenchyma was in close proximity hilar structures.Renal vein be patent tumour seen anterior the wall [Table /Fig-1].No emboli were no other lesions suggestive distant metastasis seen.Diagnosis RCC made as imaging findings suggested origin kidney.Due well circumscribed nature favouring...
Background and Objectives: Pancytopenia is one of the most common indications for bone marrow (BM) examination. There are spectrums condition involving that can present with pancytopenia include malignant as well benign diseases. The objective this study to evaluate BM findings in cases pancytopenia. Materials Methods: This was a retrospective 156 presenting over period 3 years. Data were retrieved from laboratory clinical records analysed. Results: Out cases, cause megaloblastic anemia...
<b><i>Objective:</i></b> To analyze the cases diagnosed as myeloid sarcoma on fine-needle aspiration cytology (FNAC) of lymph nodes. <b><i>Study Design:</i></b> Ten node aspirate were analyzed. FNAC was performed a routine outpatient procedure in all cases. Correlation with peripheral smear, bone marrow examination, flow cytometry and cytogenetics done wherever possible. <b><i>Results:</i></b> Diagnosis hematologic...
To put forth the cytological features and diagnostic pitfalls of spontaneously infarcted breast lesions on fine-needle aspiration cytology (FNAC).We present 19 cases encountered FNAC over a 5-year period. Histological follow-up was correlated wherever available.The majority were seen in second decade life. The smears all cellular. cytomorphologic findings scattered dyscohesive cells (n = 16), ghost 11) necrosis 10). small had normal nuclear cytoplasmic ratio with pyknotic nuclei. presence...
In the compact and haploid genome of Dictyostelium discoideum control transposon activity is particular importance to maintain viability. The non-long terminal repeat retrotransposon TRE5-A amplifies continuously in D. cells even though it produces considerable amounts minus-strand (antisense) RNA presence an active interference machinery. Removal host-encoded C-module-binding factor (CbfA) from resulted a more than 90 % reduction both plus- strong decrease retrotransposition cellular...
Brown tumor (BT) is caused by altered metabolism of calcium resulting from hyperparathyroidism (primary or secondary). The most common cause isolated parathyroid adenoma (PA), and the symptoms are hypercalcemia related. BT considered as a late manifestation PA usually diagnosed after surgical treatment bony lesion. Fine-needle aspiration cytology (FNAC) cheap, easy, less traumatic procedure should be performed in all lesions wherever possible unnecessary surgeries may avoided. We here report...
ABSTRACT Production of ribosomes is an energy-intensive process owing to the intricacy these massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins and four non-coding RNAs. Accurate assembly requires precise regulation protein RNA subunits. In response stress, integrated stress (ISR) rapidly inhibits global translation. How rRNA coordinately regulated with rapid inhibition synthesis not known. Here we show that specifically first step processing. Unprocessed...
Background- Bone marrow is an important site for metastasis in cases of non hematological malignancies and routinely performed to stage the disease or rule out suspected cases.. Purpose- Purpose study evaluate bone solid tumors also enumerate types metastasizing at our institute. Methods- This was a retrospective clinical laboratory data were retrieved from case files records. All where aspirate staging included along with those patient presented us abnormalities diagnosed have marrow....
Abstract Background: Breast cancer is arising as the most common among women. Axillary lymph node status considered one of important predictors survival in breast and a very component to staging system. The tumors under skin have abundant access dermal lymphatic an increased chance metastasizing draining nodes. Aim Study: To evaluate whether distance tumor can be predictor for metastasis. Materials Methods: This was retrospective study on all operated cases infiltrating mammary carcinoma...
Background: Decalcification of bone is a very important procedure in pathology especially an oncology set up for proper staging, chemotherapy response or even diagnosis tumors. Objectives- To evaluate the use tissue floatation bath (TFB) rapid decalcification mandibulectomy specimens setup. Materials and Methods: Bony received at department were sliced using saw then placed 10% formalin 45 0 C 4 hours. These sections kept overnight nitric acid TFB decalcification. was checked manually next...