A5089711766- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Plant Pathogenic Bacteria Studies
- Plant and Fungal Interactions Research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
- Plant Virus Research Studies
- Redox biology and oxidative stress
- Cancer Mechanisms and Therapy
- DNA Repair Mechanisms
- Protein Degradation and Inhibitors
- Amyotrophic Lateral Sclerosis Research
- Histone Deacetylase Inhibitors Research
- Polish Law and Legal System
Poznan University of Medical Sciences
2020-2024
Institute of Plant Protection
2015
The production of ribosomes is an energy-intensive process owing to the intricacy these massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins and four non-coding RNAs. Accurate assembly requires precise regulation protein RNA subunits. In response stress, integrated stress (ISR) rapidly inhibits global translation. How rRNA coordinately regulated with rapid inhibition synthesis not known. Here, we show that specifically first step processing. Unprocessed stored...
Platinum-based antineoplastic drugs, such as cisplatin, are commonly used to induce tumor cell death. Cisplatin is believed apoptosis a result of cisplatin-DNA adducts that inhibit DNA and RNA synthesis. Although idea damage underlines anti-proliferative effects cisplatin dominant in cancer research, there poor correlation between the degree sensitivity extent platination. Here, we examined possible on post-transcriptional gene regulation may contribute cisplatin-mediated cytotoxicity. We...
A collection of 147 Potato virus Y (PVY) isolates from tomato, originating several commercial fields and greenhouses in different regions Poland, was tested for the presence PVY by reverse-transcription polymerase chain reaction. However, some cases, results obtained were ambiguous. Therefore, a sensitive loop-mediated isothermal amplification method developed rapid detection isolates. Phylogenetic recombination analyses performed based on sequences coat protein gene. In comparison with...
Cancer cells show significant dysregulation of genes expression, which may favor their survival in the tumor environment. In this study, cellular vault’s components MVP (major vault protein), TEP1 (telomerase-associated protein 1) and vPARP (vault poly(ADP-ribose) polymerase) were transiently or completely inhibited U2OS (human bone osteosarcoma epithelial cells) to evaluate impact on cell proliferative migratory capacity as well development resistance drug vinorelbine. Comparative analysis...
ABSTRACT Production of ribosomes is an energy-intensive process owing to the intricacy these massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins and four non-coding RNAs. Accurate assembly requires precise regulation protein RNA subunits. In response stress, integrated stress (ISR) rapidly inhibits global translation. How rRNA coordinately regulated with rapid inhibition synthesis not known. Here we show that specifically first step processing. Unprocessed...
Ocular abnormalities are becoming associated with a spectrum of pathological events in various neurodegenerative diseases. Huntington’s disease (HD) is just such an example fatal neurological disorder, where mutated genes (CAG trinucleotide expansions the Huntingtin gene) have widespread expression, leading to production mutant (mHTT) protein. It well known that HTT protein prone form toxic aggregates, which typical feature, along global transcriptome alterations. In this study, we employed...
Some chemotherapy drugs modulate the formation of stress granules (SGs), which are RNA-containing cytoplasmic foci contributing to response pathways. How SGs mechanistically contribute pro-survival or pro-apoptotic functions must be better defined. The drug lomustine promotes SG by activating stress-sensing eIF2α kinase HRI (encoded EIF2AK1 gene). Here, we applied a DNA microarray-based transcriptome analysis determine genes modulated lomustine-induced and suggest roles for in this process....
PHA pretreatment if given as a single stimulus exerted stimulatory effect on SRBC haemolysin production rats. If administered repeatedly, it proved to be immunosuppressive.
Abstract Stress granules (SGs) are cytoplasmic structures found in eukaryotic cells, from yeast to human cells. They made up of proteins, RNA and small ribosome subunits (40S). arise as a result the rapid shutdown active protein biosynthesis cell, which is appearance stress factor. The mechanism regulation response takes place at two control nodes: (1) phosphorylation α subunit eIF2 factor action stress-recognizing kinases or by modulation mTOR pathway activity, regulates initiation...