A5055895883- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Pregnancy and preeclampsia studies
- Pharmacological Effects of Natural Compounds
- Vitamin D Research Studies
- Bone health and treatments
- Phytochemistry and Biological Activities
- Folate and B Vitamins Research
- Birth, Development, and Health
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Bioactive Compounds
- Renal Transplantation Outcomes and Treatments
- Drug Transport and Resistance Mechanisms
- Gestational Diabetes Research and Management
- Pharmacogenetics and Drug Metabolism
- Medicinal Plants and Neuroprotection
- Nutrition, Genetics, and Disease
- Medicinal Plant Extracts Effects
- Phytoestrogen effects and research
- Ovarian function and disorders
- Natural product bioactivities and synthesis
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
Institute of Natural Fibres and Medicinal Plants
2016-2025
Poznan University of Medical Sciences
2010-2025
Heliodor Swiecicki Clinical Hospital
2025
Pomeranian Medical University
2014-2022
Podhale State Higher Vocational School in Nowy Targ
2014-2015
PharmacoGenetics (China)
2014-2015
Medicina
2013-2015
Medical University of Warsaw
2014
Vitamin D affects bone metabolism and calcium-phosphate metabolism. Its deficiency leads to mineralization disorders is the cause of abnormal skeletal development from fetal life period completed growth. In later periods life, vitamin disorders, i.e., osteoporosis. Disturbance balance between osteoblasts responsible for formation osteoclasts associated with resorption results in reduced mass weakening, consequently susceptibility fractures. Analysis genetic variants receptor (VDR) concerns...
Melissa officinalis (MO, English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for prevention treatment nervous disturbances. The aim our study was to assess effect subchronic (28-fold) administration a 50% ethanol extract MO leaves (200 mg/kg, p.o.) compared with rosmarinic acid (RA, 10 huperzine A (HU, 0.5 on behavioral cognitive responses scopolamine-induced rats. results were linked acetylcholinesterase (AChE),...
Inflammation is the critical component of neuropathic pain; therefore, this study aimed to assess potential anti-inflammatory effects Cannabis sativa L. extracts in a vincristine-induced model pain. The different doses (5.0–40.0 mg/kg) two (B and D) on COX-1, COX-2, TNF-α, NF-κB mRNA protein levels were examined rat hippocampus, cerebral cortex, blood lymphocytes. There statistically significant differences TNF-α expression hippocampus with COX-2 Extract D dose-dependently increased COX-1...
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), has triggered an enormous scientific response. Many studies have focused on understanding the entry of SARS-CoV-2 into host cell. angiotensin-converting enzyme-2 (ACE2) is recognized as receptor used to enter its target cells. Recent suggest that ACE2 gene polymorphisms might be candidates for genetic susceptibility infection. aim this study evaluate influence disease risk and severity. In...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Łukasz Mikołajczak P, Kędzia B, Ożarowski M, et al. Evaluation of anti-inflammatory and analgesic activities extracts from herb Chelidonium majus L. Central European Journal Immunology. 2015;40(4):400-410. doi:10.5114/ceji.2015.54607. APA Mikołajczak, P., Kędzia, B., Ożarowski, M., Kujawski, R., Bogacz, A., & Bartkowiak-Wieczorek, J. (2015). Immunology, 40(4), 400-410. https://doi.org/10.5114/ceji.2015.54607...
The aim of the study was to investigate combined effects flavonoids (apigenin, baicalein, chrysin, quercetin, and scutellarin) methyldopa on expression selected proinflammatory vascular factors in vitro for prediction their action pregnancy-induced hypertension. research conducted a trophoblast-derived human choriocarcinoma cell line primary umbilical vein endothelial line. Cytotoxicity compounds concentrations (20, 40, 100 µmol) measured using MTT test concentration 40 µmol further...
The conjugate 8 was obtained as a result of condensation 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect OAO-ASA (8) for the range doses 0.3 – 300.0 mg/kg (p.o.) performed mice using hot plate test. Anti-inflammatory activity assessed on carrageenan-induced paw edema rats same doses. did not significantly change locomotor mice, therefore sedative properties compound should be excluded. proved simple, proportional, dose-dependent analgesic action expressed...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A number PCOS complications may be associated with the elevated level angiotensin II and low bradykinin concentrations. The aim present study was to investigate frequencies converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms determine association between ACE genetic variants risk metabolic cardiovascular such women. total 138 patients 110 healthy volunteers were enrolled....
Eryngium planum L. (EP) is as a rare medicinal plant with lot of potentials pharmaceutical crops. The aim our study was to assess the effect subchronic (28-fold) administration 70% ethanol extract EP roots (200 mg/kg, p.o.) on behavioral and cognitive responses in Wistar rats linked acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), beta-secretase (BACE-1) mRNA levels AChE BuChE activities hippocampus frontal cortex. On last day experiment, 30 min after dose or Huperzine A (HU),...
Objectives: Recent studies have demonstrated that disorders of bone metabolism, which is regulated by RANK/RANKL/OPG signaling pathway, are the cause osteoporosis. The aim study was to investigate distribution genotypes RANK 575C>T and RANKL –643C>T polymorphisms analyze their relationship with parameters in postmenopausal women. Material methods: A total 310 Caucasian women (139 osteoporosis, 107 osteopenia, 64 healthy controls) were included. Bone mineral density (BMD) at lumbar region...
P450 kodujących enzymy I fazy metabolizmu leków
A few years ago it was shown that disturbed metabolism of the vitamin D/receptor (VD/VDR) complex may be important in etiology spontaneous abortion, as well recurrent miscarriages (RM). The goal this study to investigate association between four maternal VDR polymorphisms haplotypes settings and RM occurrence a Polish population women reproductive age. total 230 were recruited (110 with RM, 120 consecutively age-matched healthy at least two full-term pregnancies no history miscarriages). DNA...
Recognition of different genetic variants underlying osteoporosis would make it possible to introduce individual, symptomatic treatment as well early prophylaxis osteoporosis. The aim the study was evaluate frequency rs2275913 (−197G > A) polymorphism IL-17 gene and assess relation this with clinical parameters osseous turnover degree postmenopausal included 800 women (505) reproductive (295) ages throughout Wielkopolska region in Poland. group osteopenia, those who were healthy. Women at...
Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC a heterogeneous group with regards to its molecular pathogenesis and genetic factors. Both variations anthropometric factors may affect morbidity patients. The aim this study was assess impact multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 general on risk.The included 250 patients who underwent colonoscopy polypectomy between 2006 2013...
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS characterized by anovulation, polycystic ovaries, hyperandrogenism leading to infertility, dermatological and psychological problems, as well risk developing Metabolic Syndrome (MetS) cardiovascular disease (CVD). The exact cause remains unclear. Various biochemical genetic markers have been implicated predisposition PCOS, but no single variant has associated with syndrome....
Cancer is the second most common cause of death, with breast cancer (BC) as frequently diagnosed neoplasm among females. The origin BC multifactorial and depends on environmental genetic factors. disease presents a significant challenge due to its drug resistance frequent metastasis. Thus, new effective therapies metastasis prevention are much needed. Rosmarinic acid (RA) natural polyphenol which possesses ability inhibit cell proliferation demonstrates cytotoxic properties against those...
BACKGROUND Immunosuppressive drugs such as cyclosporine A (CsA) are characterized by a narrow therapeutic range and high interindividual pharmacokinetic variations. Therefore, the effective monitoring of drug serum level is crucial for successful therapy. This variability can be caused polymorphisms in genes encoding transporters enzymes responsible biotransformation. The aim this study was to determine relationship between CYP3A4*1B MDR1 dose requirements achieve target CsA. MATERIAL AND...
This study was designed to investigate the relationship between levels of select adipocytokines (adiponectin, visfatin and apelin) angiotensin in converting enzyme (ACE) gene insertion/deletion (ID) polymorphism lean women with without polycystic ovary syndrome (PCOS). The PCOS group (N = 94) identified according Rotterdam criteria. Control 68) included age- body mass index (BMI)-matched healthy volunteers. Serum were measured using immunoassays (EIA) ACE genes evaluated by polymerase chain...