A5019580029- Reproductive Biology and Fertility
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- TGF-β signaling in diseases
- Diabetes Management and Research
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Tissue Engineering and Regenerative Medicine
- Endometriosis Research and Treatment
- Kruppel-like factors research
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetic Syndromes and Imprinting
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Ovarian cancer diagnosis and treatment
- Hormonal and reproductive studies
- Birth, Development, and Health
- Reproductive Physiology in Livestock
- Menopause: Health Impacts and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Lipid metabolism and disorders
Poznan University of Medical Sciences
2013-2024
University of Life Sciences in Poznań
2015
Aims The aim was to evaluate the outcome of pregnancies with type 1 diabetes ( T 1DM) treated from first trimester continuous subcutaneous insulin infusion CSII ) or multiple daily injections MDI ). Methods In a retrospective, observational study, we matched 64 patients for age, age at onset and duration H b A 1c in pregnancies. We analysed carbohydrate metabolism, requirements, development PIH , progression retinopathy fetal outcome. Results group, found significantly smaller requirement...
Because of the deep involvement granulosa cells in processes surrounding cycles menstruation and reproduction, there is a great need for deeper understanding ways which they function during various stages those cycles. One main influence numerous sex associated hormonal interaction. Expression steroid hormones influences range both primary secondary sexual characteristics, as well regulate oogenesis, folliculogenesis, ovulation, pregnancy. Understanding exact molecular mechanisms underlying...
Proper course of folliculogenesis and oogenesis have an enormous impact on female fertility. Both processes take place in the ovary involve not only maturing germ cell, but also few types somatic cells that assist ovarian mediate dialog with oocyte. These cells, granulosa theca, are heavily involved essential reproductive processes, such as ovulation, fertilization, embryo implantation. In this study, we used expressive microarray approach to analyze transcriptome porcine during short-term...
Recurrent implantation failure (RIF) is a global health issue affecting significant number of infertile women who undergo in vitro fertilization (IVF) cycles. Extensive vasculogenesis and angiogenesis occur both maternal fetal placental tissues, vascular endothelial growth factor (VEGF) fibroblast (FGF) family molecules their receptors are potent angiogenic mediators the placenta. Five single nucleotide polymorphisms (SNPs) genes encoding angiogenesis-related factors were selected genotyped...
The human ovarian granulosa cells (GCs) surround the oocyte and form proper architecture of follicle. ability GCs to proliferate differentiate in conditions vitro culture has been proven. However, there is still a large field for extensive investigation molecular basics, as well marker genes, responsible these processes. This study aimed find new encoding proteins that regulate capability proliferation differentiation during long-term primary culture. follicular were collected from...
The growth and development of oocyte affect the functional activities surrounding somatic cells. These cells are regulated by various types hormones, proteins, metabolites, regulatory molecules through gap communication, ultimately leading to maturation oocytes. close association between oocytes, which together form cumulus-oocyte complexes (COCs), their bi-directional communication crucial for acquisition developmental competences oocyte. In this study, oocytes were extracted from ovaries...
The physiological processes that drive the development of ovarian follicle, as well process oogenesis, are quite known. Granulosa cells major players in this occurrence, being somatic element female gamete development. They participate directly building cumulus-oocyte complex surrounding ovum. In addition to that, they have a further impact on reproductive processes, place steroid sex hormone synthesis and secretion. It is known follicle creates need for angiogenesis blood vessel ovary....
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A number PCOS complications may be associated with the elevated level angiotensin II and low bradykinin concentrations. The aim present study was to investigate frequencies converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms determine association between ACE genetic variants risk metabolic cardiovascular such women. total 138 patients 110 healthy volunteers were enrolled....
Oocyte maturation is essential for proper fertilization, embryo implantation and early development. While the physiological conditions of these processes are relatively well‑known, its exact molecular mechanisms remain widely undiscovered. growth, differentiation therefore subject scientific debate. Precious literature has indicated that oocyte itself serves a regulatory role in underlying processes. Hence, present study performed expression microarrays to analyze complete transcriptome...
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder, affecting 5–10% of women reproductive age. It results from complex environmental factors, genetic predisposition, hyperinsulinemia, hormonal imbalance, neuroendocrine abnormalities, chronic inflammation, autoimmune disorders. PCOS impacts menstrual regularities, fertility, dermatological complications, may induce disturbances, diabetes, coronary heart disease. Comprehensive profiling patients with be a...
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS characterized by anovulation, polycystic ovaries, hyperandrogenism leading to infertility, dermatological and psychological problems, as well risk developing Metabolic Syndrome (MetS) cardiovascular disease (CVD). The exact cause remains unclear. Various biochemical genetic markers have been implicated predisposition PCOS, but no single variant has associated with syndrome....
This study was designed to investigate the relationship between levels of select adipocytokines (adiponectin, visfatin and apelin) angiotensin in converting enzyme (ACE) gene insertion/deletion (ID) polymorphism lean women with without polycystic ovary syndrome (PCOS). The PCOS group (N = 94) identified according Rotterdam criteria. Control 68) included age- body mass index (BMI)-matched healthy volunteers. Serum were measured using immunoassays (EIA) ACE genes evaluated by polymerase chain...
Abstract The efficiency of the process obtaining mature oocytes, and then porcine embryos in vitro depends on many factors requires meeting conditions. These include selection morphologically appropriate medium components, as well a number abiotic (appropriate microenvironment during culture). Oocytes were taken from 45 pubertal crossbred Landrace gilts. BCB test was carried out. + oocytes divided into two groups: “before IVM” “after IVM”. “Before subjected to molecular analyzes immediately...
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in premenopausal women, associated with risk of metabolic and cardiovascular disease (CVD). CVD evaluation recommended for PCOS patients. This study aimed to evaluate the patients identify best predictors disturbances.The included 169 110 healthy women reproductive age. We estimated according American Heart Association Androgen Excess-PCOS Society criteria that classified as metabolically unhealthy (MU) or (MH).The group had...
Abstract Context Higher prevalence of polycystic ovary syndrome (PCOS) in women with type 1 diabetes (T1DM) is linked to exogenous insulin, especially when diagnosed before puberty. Objective The study evaluates the impact prepubertal onset T1DM and insulin therapy on PCOS diagnosis phenotypic characteristics T1DM. Design, Setting, Patients We studied 83 (age 26 ± 5 years, BMI 24 3 kg/m2) 36 premenarchal (PM) [17 (PCOS+PM) 19 without (noPCOS+PM)] 47 postmenarchal [24 (PCOS-noPM) 23...
Abstract An oviduct is an essential organ for gamete transport, oocyte maturation, fertilization, spermatozoon capacitation and early embryo development. The epithelium plays important role in functioning. products of secretory cells provide optimal environment influence activities embryonic physiology changes during the female cycle, thus, ratio secreted molecules fluid differs between phases. In this study, a differential gene expression porcine epithelial was examined long-term primary...
Granulosa cells (GCs) have many functions in the endocrine system. Most notably, they produce progesterone following ovulation. However, it has recently been proven that GCs can change their properties when subjected to long‑term culture. In present study, were collected from hyper‑stimulated ovarian follicles during vitro fertilization procedures. They grown vitro, a manner. RNA was 1, 7, 15 and 30 days of Expression microarrays used for analysis, which allowed identify groups genes...
An attempt was made to demonstrate the superiority of treatment model using continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) in achieving a successful pregnancy outcome and good newborn's condition patients with type 1 diabetes.The study included 297 infants born diabetic patients; 175 were treated MDI 122 CSII. Maternal metabolic control during pregnancy, gestational weight gain, requirements, neonatal status compared between CSII arm. The composite...
Objectives: Preconception counseling, maternal health-related habits, diet, folic acid consumption, substances abuse, may all impact the outcome of pregnancy. The aim this study was to compare planning and preparation for pregnancy among pregnant women with without infertility. Material methods: A survey health behaviors prior during that could affect outcomes, including laboratory tests performed, stimulant usage, initiation prenatal care, intake, conducted 400 women. group included 121...