Baby A. Satravada
A5046762003- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Bioinformatics and Genomic Networks
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical and Engineering Education
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Biotechnology and Related Fields
- Lung Cancer Treatments and Mutations
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Single-cell and spatial transcriptomics
- Machine Learning in Healthcare
- Biomedical Text Mining and Ontologies
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
Memorial Sloan Kettering Cancer Center
2021-2024
Kettering University
2022-2024
Molecular Oncology (United States)
2021-2023
Abstract International cancer registries make real-world genomic and clinical data available, but their joint analysis remains a challenge. AACR Project GENIE, an international registry collecting from 19 centers, makes >130,000 patients publicly available through the cBioPortal for Cancer Genomics (https://genie.cbioportal.org). For 25,000 patients, additional longitudinal data, including treatment outcome are being collected by GENIE Biopharma Collaborative using PRISSMM curation...
Cancer classification is foundational for patient care and oncology research. Systems such as International Classification of Diseases Oncology (ICD-O), Systematized Nomenclature Medicine Clinical Terms (SNOMED-CT), National Institute Thesaurus (NCIt) provide large sets cancer terminologies but they lack a dynamic modernized platform that addresses the fast-evolving needs in clinical reporting genomic sequencing results associated research.To meet these needs, we have developed OncoTree, an...
The digitization of health records and growing availability tumour DNA sequencing provide an opportunity to study the determinants cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text siloed datasets. Here we combine natural language processing annotations1,2 structured medication, patient-reported demographic, registry genomic from 24,950 patients at Memorial Sloan Kettering Cancer Center generate a clinicogenomic, harmonized oncologic real-world...
Gallbladder carcinoma (GBC) is an uncommon and aggressive disease, which remains poorly defined at a molecular level. Here, we aimed to characterize the landscape of GBC identify markers with potential prognostic therapeutic implications.
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics analyze human tissue samples at different stages of development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), invasive HGSOC. Our findings reveal immune modulating mechanisms within precursor...
Abstract High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics analyze human tissue samples at different stages of development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), invasive HGSOC. Our findings reveal immune modulating mechanisms within...
159 Background: Advancing genetic and computational technologies have increased the complexity quantity of data available in field rectal cancer research. As such, there is a need for centralized source to aid organize current research efforts. To this end, our team has created unique online biorepository tumoroids which may serve as resource community researchers. Methods: The tumoroid was cBioPortal 2015. Organoids were derived from patient tumor samples (tumoroids). These represented...
Abstract cBioPortal for Cancer Genomics is an open-source platform interactive, exploratory analysis of large-scale clinico-genomic data. provides a suite user-friendly visualizations and analyses, including OncoPrints, mutation lollipop plots, variant interpretation, group comparison, survival analysis, expression correlation alteration enrichment cohort patient-level visualization. The public site (https://www.cbioportal.org) accessed by >35,000 unique visitors each month hosts data...
Abstract cBioPortal for Cancer Genomics is an open-source platform interactive, exploratory analysis of large-scale clinico-genomic data sets. provides a suite user-friendly visualizations and analyses, including OncoPrints, mutation “lollipop” plots, variant interpretation, group comparison, survival analysis, expression correlation alteration enrichment cohort patient-level visualization. The public site (https://www.cbioportal.org) accessed by >35,000 unique visitors each month...
<p>List of AACR Project GENIE Consortium Members</p>
<div>AbstractPurpose:<p>Gallbladder carcinoma (GBC) is an uncommon and aggressive disease, which remains poorly defined at a molecular level. Here, we aimed to characterize the landscape of GBC identify markers with potential prognostic therapeutic implications.</p>Experimental Design:<p>GBC samples were analyzed using MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling Actionable Cancer Targets) platform (targeted NGS assay that analyzes 505...
<div>AbstractPurpose:<p>Gallbladder carcinoma (GBC) is an uncommon and aggressive disease, which remains poorly defined at a molecular level. Here, we aimed to characterize the landscape of GBC identify markers with potential prognostic therapeutic implications.</p>Experimental Design:<p>GBC samples were analyzed using MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling Actionable Cancer Targets) platform (targeted NGS assay that analyzes 505...
<p>Figure S2. Microbiome analysis in GBC.</p>
<p>supplementary legend</p>
<p>Table S3. Therapy regimens</p>
<p>Table S1. Sample list (cBioPortal identifiers, ‘DMP_SAMPLE_ID’). Only the primary tumor (if available) or earliest collected metastasis are included (n=233)</p>
<p>supplementary legend</p>
<p>Detailed statistical results</p>
<p>Table S2. Oncogenic/Likely-oncogenic structural variants in GBC</p>
<p>Detailed statistical results</p>
<p>Table S1. Sample list (cBioPortal identifiers, ‘DMP_SAMPLE_ID’). Only the primary tumor (if available) or earliest collected metastasis are included (n=233)</p>
<p>Figure S1. Mutation signatures and altered canonical pathways in GBC.</p>
<p>Table S3. Therapy regimens</p>
<p>Figure S2. Microbiome analysis in GBC.</p>