A5101496130- Genetic and phenotypic traits in livestock
- Animal Disease Management and Epidemiology
- Cancer Genomics and Diagnostics
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Animal Behavior and Reproduction
- Animal Virus Infections Studies
- Animal Behavior and Welfare Studies
- Animal Genetics and Reproduction
- Genetic factors in colorectal cancer
- Stroke Rehabilitation and Recovery
- Economic and Financial Impacts of Cancer
- Viral Infections and Vectors
- Mobile Health and mHealth Applications
- Genomics and Rare Diseases
- Reproductive System and Pregnancy
- Identity, Memory, and Therapy
- Effects of Environmental Stressors on Livestock
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
- Ovarian function and disorders
- Healthcare professionals’ stress and burnout
Memorial Sloan Kettering Cancer Center
2023-2024
Jilin University
2023-2024
Hendrix Genetics (Canada)
2023-2024
Kettering University
2023-2024
University of Alberta
2019-2023
Second Affiliated Hospital of Jilin University
2021-2022
Weatherford College
2021
Food & Nutrition
2019
The digitization of health records and growing availability tumour DNA sequencing provide an opportunity to study the determinants cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text siloed datasets. Here we combine natural language processing annotations1,2 structured medication, patient-reported demographic, registry genomic from 24,950 patients at Memorial Sloan Kettering Cancer Center generate a clinicogenomic, harmonized oncologic real-world...
Cancer genomes from patients with African (AFR) ancestry have been poorly studied in clinical research. We leverage two large genomic cohorts to investigate the relationship between alterations and AFR six common cancers. Cross-cancer type associations, such as an enrichment of MYC amplification lung, breast, prostate cancers, depletion BRAF are observed colorectal pancreatic There differences actionable alterations, KRAS G12C EGFR L858R, ROS1 fusion lung Interestingly, cancer, mutations...
ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior the estimation of genetic parameters. However, impact different on parameter estimates depends dataset at hand. The objective this study was evaluate effects eight common ( z ‐score, log, square root, probit, arcsine, logit, Box‐Cox and Yeo‐Johnson) for fitness in turkeys. Three fertility turkeys were analysed. Egg production...
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It anticipated that improved disease will sustainably increase production efficiency, as resilient animals maintain their performance the face of infection. The objective this study was identify phenotypes related using complete blood count (CBC) data from wean-to-finish natural challenge model, established mimic pressure caused by many common pathogens at commercial level pig production. In total, 2433...
Abstract Background Disease resilience, which is the ability of an animal to maintain performance under disease, important for pigs in commercial herds, where they are exposed various pathogens. Our objective was investigate population-level gene expression profiles blood 912 healthy F1 barrows at ~ 27 days age associations with and health before after their exposure a natural polymicrobial disease challenge 43 age. Results Most significant ( q < 0.20) level individual genes young were...
This study aimed to explore the genetic basis of walking ability and potentially related performance traits in turkey purebred populations. Phenotypic, pedigree, genomic datasets from 2 lines hatched between 2010 2023 were included study. Walking data, defined based on a scoring system ranging 1 (worst) 6 (best), collected 192,019 animals female line 235,461 male line. Genomic information was obtained for 46,427 turkeys (22,302 24,125 line) using 65K single nucleotide polymorphism (SNP)...
Abstract Background Genetic improvement for disease resilience is anticipated to be a practical method improve efficiency and profitability of the pig industry, as resilient pigs maintain relatively undepressed level performance in face infection. However, multiple biological functions are known involved this complexity means that genetic architecture remains largely unknown. Here, we conducted genome-wide association studies (GWAS) 465,910 autosomal SNPs complete blood count (CBC) traits...
The aim of this study was to investigate the potential non-linear relationship between growth and walking ability (WA). phenotypic data included body weights at 12 20 weeks WA age measured on 276,059 male turkeys. rate three periods (0 12, 0 weeks) calculated. Each bird assigned one quartiles distribution for each period. Between first fourth quartiles, incidence score 1 (bad WA) increased by 31, 18, 33% first, second, third periods, respectively. For good (scores 4, 5, 6), decreased 55, 66,...
You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation II (MP35)1 May 2024MP35-03 INVESTIGATING TOBACCO USE AND GENETIC ANCESTRY IN THE GENOMICS OF UROTHELIAL BLADDER CANCER USING NATURAL LANGUAGE PROCESSING NEXT GENERATION TUMOR SEQUENCING Kelly R. Pekala, Xuechun Bai, Justin Jee, Tomin Perea-Chamblee, Michele Waters, Chris Fong, Ronglai Shen, Niki Schultz, Richard Matulewicz, Eugene Pietzak, and Jian Carrot-Zhang PekalaKelly Pekala , BaiXuechun Bai JeeJustin Jee...
The COVID-19 epidemic has affected the psychological well-being and daily life of college students, leading to a decrease in their quality life. Health status can be influenced by variety factors. This study aims assess current health university students explore relationships among care knowledge, self-efficacy, healthy lifestyle behaviors, how these factors are influenced. Among 1694 participants, 49.4% were male, 50.6% female, 82.2% freshmen. results revealed that across all dimensions...
Abstract Allostatic load (AL) is the cumulative burden of chronic stress and life events typically measured by lab vital values routinely collected during standard care. AL has been associated with adverse socioenvironmental stressors increased mortality rates including risk cancer death. Despite modifications as a result progressing anti-cancer treatments, may serve valuable biomarker for outcomes, highlight similar disparities across sociodemographic groups agnostic history diagnosis....
Abstract Genetic similarity of populations (or genetic ancestry) contributes to cancer driving alterations. We performed a meta-analysis leveraging two real-world cohorts targeted gene panel sequencing, comprising 275,605 tumor samples, investigate ancestry-associated somatic alterations across 14 common cancers. focused on five continental ancestries – European (EUR), African (AFR), East Asian (EAS), South (SAS), and admixed American (AMR). ancestry was inferred using single nucleotide...
Abstract Background: Colorectal cancer (CRC) patients of African ancestry (AFR) have higher incidence, mortality, and shorter overall survival (OS) than non-African (non-AFR) in the United States. This disparity is likely due to a combination clinical, genomic, socioeconomic factors. We investigated real-world data from single tertiary center delineate contribution each those variables. Methods: analyzed 3,995 CRC patients, including 247 AFR 3,748 non-AFR diagnosed after 2014 treated at...
PURPOSE In lung squamous cell carcinoma (LUSC), Black patients show significantly higher incidence and lower overall survival than White patients. Although socioeconomic factors likely contribute to this disparity, genomic have yet be elucidated in LUSC. METHODS Using 416 LUSC tumor samples the Cancer Genome Atlas (TCGA), we assessed transcriptomic profiles by ancestry. We replicated our analyses pan-cancer data from TCGA, American Association of Research (AACR) Genomics Evidence Neoplasia...
The purpose of this study was to explore plasma metabolite levels in young healthy pigs and their potential association with disease resilience estimate genetic phenotypic correlation the change lymphocyte concentration following challenge. Plasma samples were collected from 968 nursery over 15 batches at an average 28 ± 3.23 d age. Forty-four metabolites identified quantified by nuclear magnetic resonance. Pigs then introduced into a natural challenge barn, classified four groups based on...
Abstract BackgroundGenetic improvement for disease resilience is anticipated to be a practical method improve efficiency and profitability of the pig industry, as resilient pigs maintain relatively undepressed level performance in face infection. However, multiple biological functions are known involved this complexity means that genetic architecture remains largely unknown. Here, we conducted genome-wide association studies (GWAS) 465,910 autosomal SNPs complete blood count (CBC) traits...
Abstract Rationale: Chromosome 18 long arm deletion syndrome is a group of clinical syndromes caused by partial or total genetic material the chromosome (18q), whose manifestations are related to presentation and developmental abnormalities in various aspects such as intelligence, face, movement. Prenatal diagnosis this challenging because its low incidence uncharacteristic prenatal performance. In paper, 2 cases 18q found amniotic fluid examination high-throughput sequencing were reported...
Abstract Infectious diseases impact the swine industry through increased morbidity and mortality, leading to large economic losses reduced animal welfare. Disease resilience is ability of an maintain production performance under pathogen exposure has gained traction as approach help reduce infectious disease. For this purpose, a wean-to-finish polymicrobial natural disease challenge model was set up, in which, using continuous flow system, batches 60 or 75 young healthy Landrace × Yorkshire...