A5102101471- Enzyme Production and Characterization
- Protein Hydrolysis and Bioactive Peptides
- Studies on Chitinases and Chitosanases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver physiology and pathology
- HIV Research and Treatment
- Biofuel production and bioconversion
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Aquaculture disease management and microbiota
- BRCA gene mutations in cancer
- HIV/AIDS drug development and treatment
- Exercise and Physiological Responses
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- High Altitude and Hypoxia
- Microbial Metabolic Engineering and Bioproduction
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- Tea Polyphenols and Effects
- Nanoparticles: synthesis and applications
- Cancer-related molecular mechanisms research
- Plant tissue culture and regeneration
- Heavy Metal Exposure and Toxicity
Shanghai Institute of Organic Chemistry
2024
Chinese Academy of Sciences
2024
Ocean University of China
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Fishery Sciences
2024
Beijing Normal University
2024
Nanjing Agricultural University
2024
Wuhan Prevention and Treatment Center for Occupational Diseases
2023
Columbia University Irving Medical Center
2021-2023
Harbin Veterinary Research Institute
2021
Abstract Extensive decoration of backbones is a major factor resulting in resistance enzymatic conversion hemicellulose and other branched polysaccharides. Employing debranching enzymes the main strategy to overcome this kind recalcitrance at present. A carbohydrate-binding module (CBM) contiguous amino acid sequence that can promote binding various carbohydrates, thereby facilitating hydrolysis. According previous studies, CBMs be classified into four types based on their preference ligand...
Abstract Background National treatment guidelines of China evolving necessitates population-level surveillance transmitted drug resistance (TDR) to inform or update HIV strategies. Methods We analyzed the demographic, clinical, and virologic data obtained from people with (PWH) residing in 31 provinces who were newly diagnosed between 2018 2023. Evidence TDR was defined by World Health Organization list for mutations. Results Among 22 124 PWH protease reverse transcriptase sequences, 965...
Chitinases are enzymes which degrade β-1,4-glycosidid linkages in chitin. The enzymatic degradation of shellfish waste (containing chitin) to chitooligosaccharides is used industrial applications generate high-value-added products from such waste. However, chitinases currently produced with low efficiency and poor tolerance, limiting the utility. Therefore, identifying higher activity tolerance great importance.Primers were designed using genomic database Paenibacillus chitinolyticus NBRC...
Camellia sinensis var. assamica seed cake (a by-product of tea-seed oil) is an abundant resource with poor utilisation. C. saponin (CSS) one kind non-ionic surfactant. In this study, the CSS extraction conditions were optimised by response surface methodology (RSM) and then detergent was developed. Additionally, safety decontamination ability developed evaluated.The including extracting temperature 40.04 °C, time 4.97 h, ethanol concentration 64.11% liquid-solid ratio 14.57:1 mL g-1 . The...
Effective microorganisms (EM) might alleviate deterioration of soil environmental quality and yield decline pepper (
<title>Abstract</title> The lumpy skin disease virus (LSDV), a member of the <italic>Poxviridae</italic> family, is primarily characterized by formation nodules in cattle. In our study, RNA sequencing was employed to investigate LSDV-infected Madin-Darby bovine kidney (MDBK) cells. At 4 hours post-infection (hpi), 108 differentially expressed long non-coding RNAs (delncRNAs) were identified. A co-expressed functional analysis indicated that lncRNAs may influence cellular glycometabolic...
Abstract Background and Purpose Physical activity is an effective therapeutic protocol for treating chronic obstructive pulmonary disease (COPD). However, the mechanisms underlying benefits of physical in COPD are not fully elucidated. Experimental Approach In a mouse model COPD, analysis biological markers lung proteomics identified molecular pathways through which exercise ameliorates COPD. Key Results Exercise improved function, emphysema, small airway disease, inflammation, glucose...
Background: Physical activity is an effective therapeutic protocol for COPD, yet the exact mechanisms through which physical conveys its benefits are not entirely elucidated.Methods: Comprehensive analyses involving biological markers and lung proteomics were conducted to uncover molecular pathways exercise ameliorates COPD.Results: Exercise was found improve pulmonary function, emphysema, small airway disease, inflammation, glucose metabolism disorders, insulin resistance in COPD mice....
Abstract Background In 2016, China has implemented the World Health Organization's “treat all” policy. We aimed to assess impact of significant improvements in 95-95-95 targets on population-level human immunodeficiency virus (HIV) transmission dynamics and incidence. Methods focused 3 steps HIV care continuum: diagnosed, antiretroviral therapy, achieving viral suppression. The molecular clusters were inferred using HIV-TRACE. New infections estimated incidence method European Centre for...
This study aimed to estimate the distribution of hepatitis B virus (HBV) C/D recombinant in Han and Tibet patients with chronic (CHB) then learn such strain's replication capacity vivo. A total 331 serum samples were collected from outpatients Sichuan Province Tibetan Tibet. Viral genotypes these identified. An HBV replicative plasmid was constructed selected genome. Sequentially, mouse models established viral strain studied In 314 patients, 66% (207) infected by genotype while 31% (96) C...
Background: Coronary atherosclerotic disease (CAD) is often accompanied by peripheral atherosclerosis, resulting in a higher risk of ischemia and cardiovascular death. Exposure to metals associated with plaques at specific sites. However, less known about the effects mixed on systemic burden CAD patients.Methods: This was cross-sectional study from southwest China, 1562 patients were included. The concentrations 10 blood measured Inductively coupled plasma spectrometry. defined as least one...
Abstract We studied the penetrance and clinical outcomes of seven breast cancer susceptibility genes ( BRCA1, BRCA2, TP53, CHEK2, ATM, PALB2 PTEN ) in almost 25,000 participants unselected for personal or family history cancer. identified 420 with pathogenic likely variants, 147 were women who did not previously know their genetic results. Out these women, 32 diagnosed at an average age 52.8 years. Estimated by 60 years ranged from 18-44%, depending on gene. Within first twelve months after...
Abstract One-step fermentation is a cheap way to produce xylo-oligosaccharides (XOS), where production of xylanases and XOS integrated into single process. In spite having cost advantage, one-step still short in yield so far due the limited exploration. To cope with this issue, from wheat bran by recombinant Escherichia coli through was investigated here. A xylanase gene belonging glycoside hydrolase family 11 Bacillus agaradhaerens employed construct E. . This showed maximal activity at...