Chenli Zheng
A5052255559- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Cardiovascular Health and Disease Prevention
- Cytomegalovirus and herpesvirus research
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
Shenzhen Center for Disease Control and Prevention
2024-2025
Fu Wai Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Preexposure prophylaxis (PrEP) and postexposure (PEP) have been proven effective in preventing human immunodeficiency virus (HIV) transmission. Men who sex with men (MSM) incorrectly used PrEP/PEP demonstrated higher HIV positivity rates compared to both correct users non-users. Since are more likely engage unprotected anal intercourse (UAI), incorrect use of these prophylactic measures may constitute a significant risk factor for transmission among MSM. It is crucial implement strategies...
Abstract Background National treatment guidelines of China evolving necessitates population-level surveillance transmitted drug resistance (TDR) to inform or update HIV strategies. Methods We analyzed the demographic, clinical, and virologic data obtained from people with (PWH) residing in 31 provinces who were newly diagnosed between 2018 2023. Evidence TDR was defined by World Health Organization list for mutations. Results Among 22 124 PWH protease reverse transcriptase sequences, 965...
Abstract Background Shenzhen, a city with substantial mobile population, was identified as the first discovered region of human immunodeficiency virus-1 (HIV-1) CRF55_01B and epicenter its severe epidemic. During implementation venue-based behavioral interventions “treat-all” policy, identifying patterns spread transmission hotspots is imperative. Methods In this study, 1450 partial pol sequences, demographic information, were collected from all newly diagnosed infections in Shenzhen 2008 to...
In the evolution landscape of HIV, coexistence multiple subtypes has led to new, complex recombinants, posing public health challenges. CRF55_01B, first identified among MSM in Shenzhen, China, spread rapidly across China. this study, 47 plasma samples from newly diagnosed HIV-1 CRF55_01B patients which genotype was only by routine HIV drug resistance test, were collected. Multiple gene regions acquired using Sanger and next-generation sequencing methods, followed phylogenetic...
Abstract Background In 2016, China has implemented the World Health Organization's “treat all” policy. We aimed to assess impact of significant improvements in 95-95-95 targets on population-level human immunodeficiency virus (HIV) transmission dynamics and incidence. Methods focused 3 steps HIV care continuum: diagnosed, antiretroviral therapy, achieving viral suppression. The molecular clusters were inferred using HIV-TRACE. New infections estimated incidence method European Centre for...
Objective: To investigate the prevalence of albuminuria in Chinese residents aged >35 years and its potential association with cardiovascular disease (CVD). Methods: A total 34 647 subjects ≥35 were selected by stratified multi-stage random sampling from 2012 to 2015. Data collected through questionnaires, physical examinations, laboratory tests. Albuminuria was categorized into 3 types according urinary albumin-to- creatinine ratio: normal (<30 mg/g), microalbuminuria (MAU, 30-300...