Jianjun Li
A5092150654- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Metallurgical Processes and Thermodynamics
- Metal Extraction and Bioleaching
- Iron and Steelmaking Processes
Yunnan Metallurgical Group (China)
2025
Guangxi Center for Disease Prevention and Control
2023-2024
The molten salt chlorination method is one of the two main methods for producing titanium tetrachloride, an important intermediate product in industry. To effectively improve efficiency and reduce unnecessary waste generation, it necessary to understand mechanism reaction, consequently this paper conducted studies on carbon reaction salts by combining ab initio molecular dynamics (AIMD) deep potential (DeePMD) methods. use DeePMD allowed simulations a larger spatial longer time scale,...
Abstract Background National treatment guidelines of China evolving necessitates population-level surveillance transmitted drug resistance (TDR) to inform or update HIV strategies. Methods We analyzed the demographic, clinical, and virologic data obtained from people with (PWH) residing in 31 provinces who were newly diagnosed between 2018 2023. Evidence TDR was defined by World Health Organization list for mutations. Results Among 22 124 PWH protease reverse transcriptase sequences, 965...
Abstract Introduction A lower adherence rate (percentage of individuals taking drugs as prescribed) to ART may increase the risk emergence and transmission HIV drug resistance, decrease treatment efficacy, mortality rate. Exploring impact on resistance could provide insights in controlling epidemic. Methods We proposed a dynamic model incorporating CD4 cell count-dependent rates diagnosis, with transmitted (TDR) acquired resistance. This was calibrated validated by 2008–2018 HIV/AIDS...
Abstract Objectives To investigate the epidemic patterns of pretreatment drug resistance (PDR) and acquired (ADR) in HIV-1 sequences from China. Methods pol associated epidemiological data were collected Los Alamos HIV Sequence Database, NCBI, Gene Database PubMed. Genotypic subtypes identified using Stanford Drug Resistance Database. Results A total 36 263 ART-naïve individuals 1548 ART-experienced with virological failure evaluated. PDR prevalence was 6.64%, initially decreasing then...
Abstract Background In 2016, China has implemented the World Health Organization's “treat all” policy. We aimed to assess impact of significant improvements in 95-95-95 targets on population-level human immunodeficiency virus (HIV) transmission dynamics and incidence. Methods focused 3 steps HIV care continuum: diagnosed, antiretroviral therapy, achieving viral suppression. The molecular clusters were inferred using HIV-TRACE. New infections estimated incidence method European Centre for...