A5100627521- Rabies epidemiology and control
- Virology and Viral Diseases
- Microbial infections and disease research
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Vectors
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Streptococcal Infections and Treatments
- Machine Learning in Bioinformatics
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Parasites and Host Interactions
- Analytical Chemistry and Chromatography
- Protein Hydrolysis and Bioactive Peptides
- Mycobacterium research and diagnosis
- HIV Research and Treatment
- Reproductive tract infections research
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- Gut microbiota and health
- Urinary Tract Infections Management
- RNA Interference and Gene Delivery
Huaian First People’s Hospital
2025
Shenzhen Center for Disease Control and Prevention
2021-2024
Beijing Tian Tan Hospital
2023
Capital Medical University
2023
Xian Center for Disease Control and Prevention
2017-2022
East China Normal University
2019-2021
Mahidol University
2012-2021
Chinese Center For Disease Control and Prevention
2009-2020
Anhui Agricultural University
2020
National Institute for Parasitic Diseases
2019
Abstract Background The epidemic of rabies showed a rising trend in China recent years. To identify the potential factors involved emergence, we investigated and analyzed status characteristics human between 1996 2008. Moreover, infection vaccination dogs, prophylaxis humans after exposure were analyzed. Methods Human data 2008 collected from annual reports Chinese Center for Disease Control Prevention (China CDC) investigate dogs postexposure (PEP) humans, brain specimens domestic detected,...
China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial were reported southwest but are now almost every province. There have been several phylogenetic investigations into origin and spread virus within few reports investigating impact epidemic on neighboring countries. We therefore collected nucleoprotein sequences from South East Asia investigated their phylogeographic relationship. Our results indicate that Asia, isolates...
ObjectivesShenzhen is suffering severe HIV epidemic. No systematic surveillance on high risk populations, genetic diversity, transmitted drug resistance (TDR) and molecular transmission clusters (MTCs) have been reported yet. In this study, we described them based newly diagnosed positive cases from 2011 to 2018 in Shenzhen city, China.MethodsPlasma samples of Shenzhen, China were collected 2018. The pol gene was amplified sequenced for subtyping, characterization, TDR phylogenetic analysis....
Objective To analyse the characteristic features of infants with pneumonia who test positive for serum milk-specific immunoglobulin E (sIgE) and to provide a reference diagnosis, management prevention condition. Methods We retrospectively analysed data from 284 admitted our hospital between January 2017 December 2020 underwent allergen testing. Based on results, patients were categorised into three groups: pure milk sIgE-positive; mixed sIgE-negative. then compared general conditions,...
Rabies remains a serious problem in China with three epidemics since 1949 and the country midst of third epidemic. Significantly, control each outbreak has been followed by rapid reemergence disease. In 2005, government implemented rabies national surveillance program that included collection screening almost 8,000 samples. this work, we analyzed Chinese dataset comprising 320 glycoprotein sequences covering 23 provinces eight species, spanning second epidemics. Specifically, investigated...
Background: A pertussis outbreak was studied in a primary school Xi’an, China, March 2016. The consisted of 536 pupils 6–12 years age who were divided into 12 classes 6 grades (2 for each grade). identified index case an 11-year-old girl at class 2 grade 5. Methods: Interview conducted and nasopharyngeal swabs taken from all (N = 94) the Nasopharyngeal tested by both culture polymerase chain reaction (PCR). Results: Four culture- 17 PCR-positive cases 94 pupils. Infection rate significantly...
Bacterial vaginosis (BV) is a common complex associated with numerous adverse health outcomes, affecting women of different ages throughout the world. The etiology BV remains poorly understood due to difficulty establishing molecular genetic criterion recognize vaginal microbiota BV-positive from that normal women. We used techniques broad-range PCR-DGGE and gel imaging analysis system cooperated 16S rRNA gene sequencing statistical investigate community structure healthy BV-affected...
Schistosomiasis is a huge threat to human and animal health. Apart from bovines, goats play an important role in the transmission of schistosomiasis some endemic areas China. An accessible, quality-assured goat diagnostic technique needed. Recently, our laboratory identified two recombinant antigens, SjPGM SjRAD23 via immuno-proteomic method. The application these antigens develop higher sensitivity specificity for sheep diagnosis urgently Epitopes were predicted three polypeptides, one...
Abstract Bartonella quintana is a bacterium that causes broad spectrum of diseases in humans including trench fever. Humans were previously considered to be the primary, if not only, reservoir hosts for B. . To identify animal and extend our understanding ecological evolutionary history , we examined blood samples from macaques performed multilocus sequence typing ( MLST ) analysis. We demonstrated prevalence infection was common main primate centres mainland C hina. Overall, 18.0% (59/328)...
In China, rabies remains an ongoing threat to public health. Although control efforts have been effective in reducing the number of annual cases, virus continues spread into new areas. Tibet, Qinghai, Gansu and Ningxia western China have, until recently, reported only a handful events. However, since 2011, there increasing numbers cases recorded these this study, we report collection analysis samples collected from regions. We find that originate two different sources. Strains are closely...
Down syndrome cell adhesion molecule (Dscam) generates tens of thousands isoforms by alternative splicing, thereby providing crucial functions during immune responses. In this study, a novel Dscam signaling pathway was investigated in crab, which remains poorly characterized invertebrates. Bacterial infection induced the cytoplasmic cleavage intracellular domains (ICDs) γ-secretase, and then released ICDs carrying specific alternatively spliced exons could directly interact with IPO5 to...
Background. Congenital rubella syndrome (CRS) case identification is challenging in older children since laboratory markers of congenital virus (RUBV) infection do not persist beyond age 12 months. Methods. We enrolled with CRS born between 1998 and 2003 compared their immune responses to RUBV those mothers a group similarly aged without CRS. Demographic data sera were collected. Sera tested for anti–RUBV immunoglobulin G (IgG), IgG avidity, response the 3 viral structural proteins (E1, E2,...
Abstract Aims: The aim of this study was to characterize the different structures microbial communities between 20 healthy women and 17 bacterial vaginosis (BV)‐positive reproductive age using denaturing gradient gel electrophoresis (DGGE). Material Methods: Vaginal samples from BV‐positive BV‐negative were subjected DNA extraction, amplified with eubacterial 16S rRNA gene‐specific primers via polymerase chain reaction. reaction products separated DGGE. Bands excised, re‐amplified, purified...
A large-scale QSAR study of host defense peptides sheds light on the origin their bioactivities (antibacterial, anticancer, antiviral and antifungal).
The continued and general rise of antibiotic resistance in pathogenic microbes is a well-recognized global threat. Host defense peptides (HDPs), component the innate immune system have demonstrated promising potential to become next generation effective against plethora pathogens. While effectiveness antimicrobial HDPs has been extensively experimental studies, theoretical insights on mechanism by which these function comparably limited. In particular, studies AMP mechanisms are limited...