A5090784277- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Pharmacogenetics and Drug Metabolism
- Galician and Iberian cultural studies
- Epilepsy research and treatment
- Poisoning and overdose treatments
- Historical and socio-economic studies of Spain and related regions
- Spanish History and Politics
- Drug Transport and Resistance Mechanisms
- Spanish Culture and Identity
- Spanish Literature and Culture Studies
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
- Media, Journalism, and Communication History
- Blood transfusion and management
- Wound Healing and Treatments
- Medieval Iberian Studies
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Drug-Induced Adverse Reactions
- History of Education in Spain
- Graphene and Nanomaterials Applications
- Oral and gingival health research
- X-ray Diffraction in Crystallography
- Pharmaceutical studies and practices
Imperial College London
2021-2022
Institut Químic de Sarrià
2021
Universitat Ramon Llull
2021
Instituto Nacional de Salud del Niño
2020
Universitat de Barcelona
2016-2017
Hospital Universitari Arnau de Vilanova
2011
Hospital Universitario Virgen Macarena
1993-2010
Complejo Hospitalario Torrecárdenas
2006
University of the Basque Country
2005
Hospital de Magalhães Lemos
2002
A chronic adverse reaction may occur in some instances of drug-induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from a Spanish registry and evaluated cases DILI with biochemical evidence long-term damage. Chronic outcome was defined as persistent abnormality hepatocellular pattern damage more than 3 months after withdrawal or 6 cholestatic/mixed Data on 28 patients clinical evolution (mean follow-up 20 months) between November 1995 October 2005 were...
Amoxicillin-clavulanate (AC) hepatotoxicity has been reported to exhibit a higher predominance of cholestatic types damage, especially in males. However, the determinants its clinical expression are unknown. This study prospectively evaluated profile AC hepatotoxicity. Data on all cases Spanish Registry attributed and assessed as definite or probable Council for International Organizations Medical Sciences (CIOMS) scale were collated compared published case series. Hepatotoxicity related...
Drug-induced idiosyncratic liver disease (DIILD) depends largely on host susceptibility factors. Small studies support the genetic influence of human leukocyte antigen (HLA) class II molecules predisposition to DIILD. We sought associations between HLA-DRB and -DQB alleles DIILD considered collectively or according biochemical expression damage. studied a total 140 patients with definitive probable diagnosis DIILD, as assessed Council for International Organizations Medical Sciences scale,...
Drug-induced liver injury (DILI) susceptibility has a potential genetic basis. We have evaluated possible associations between the risk of developing DILI and common variants manganese superoxide dismutase ( SOD2 Val16Ala) glutathione peroxidase GPX1 Pro200Leu) genes, which are involved in mitochondrial oxidative stress management. Genomic DNA from 185 patients assessed by Council for International Organizations Medical Science scale 270 sex- age-matched controls were analyzed. The...
Abstract: A functional role for melatonin is its relationship to circadian timing mechanisms. In addition, there has recently been assumed be a connection between the pineal gland and immune system in mammals birds, with some findings showing free radical scavenger general antioxidant. The present study investigates possible rhythm of ingestion capacity as well superoxide anion levels ring dove ( Streptopelia risoria ) heterophils. heterophils, their ability ingest kill different antigens,...
Impaired cutaneous healing leading to chronic wounds affects between 2 and 6% of the total population in most developed countries it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings mechanical debridement are often not effective, causing severe pain, emotional distress, social isolation patients for years or even decades, ultimately resulting limb amputation. Alternatively, gene therapy (such as mRNA therapies) has emerged viable option...
A functional connection between the neuroendocrine and immune systems has been established. Of particular interest is finding that hormones such as melatonin corticosterone are able to exert modulating effects on function. Therefore, after determining circadian rhythms of corticosterone, we evaluated in vitro effect physiological concentrations separately together, phagocytic function superoxide anion levels heterophils ring dove ( Streptopelia risoria ). Trials were performed with...
Introducción: la reexposición al agente causal constituye un incidente potencialmente grave en hepatotoxicidad.Objetivos: evaluar las características y evolución de los casos con positiva.Material métodos: estudio retrospectivo una serie evidencia positiva incluidos el Registro Español Hepatopatías Asociadas a Medicamentos, analizando su relación variables demográficas clínicas, causalidad, consecuencias.Resultados: total 520 casos, 31 (6%) cumplían criterios reexposición.La fatal, necesidad...
OBJECTIVE: To describe a case of acute interstitial nephritis (AIN) probably related to administration diltiazem. CASE SUMMARY: A 53-year-old white man presented the hospital experiencing abdominal pain radiating both renal fossae, as well dysuria. Diltiazem and atenolol had been prescribed treat an episode precordial associated with effort. An erythematous maculopapular rash developed approximately 2 hours after single dose diltiazem, failure, elevated liver function test results, 6 days...
To analyze the characteristics of hepatotoxicity due to ticlopidine.We describe all case attributed ticlopidine and reported Register drug associated hepatopathies. We also obtained data from MEDLINE Spanish Medical Index regarding cases during period 1982 2001.We twelve hepatopathy related use ticlopidine. These made up 5% notified Register. Eighty three percent patients were male, an average age 68 years. Sixty six required hospital admission. The latent varied between 2 13 weeks. liver...
gamma-Aminobutyric acid (GABA) and sodium valproate (VPA) inhibit the formation of stress-induced gastric ulcers in guinea-pigs. The present study was conducted to evaluate effect these drugs on development cold- restraint-induced In control saline-pretreated animals, a 3 h exposure cold restriction resulted production 9 out 10 animals. GABA (200 mg kg-1 oral, i.p.) completely prevented ulcers. VPA (100 200 exerted no significant effects oral (oral) also exhibited partially protective...
A case of toxic psychosis due to cycloplegic eyedrops is reported. The characteristic mental symptoms atropine intoxication include confusion with vivid visual hallucinations, restlessness, muscular incoordination, and later emotional lability. These a short period retrograde amnesia occurred in our patient. adverse drug reaction was confirmed following rechallenge. possible preventive measures against caused by are described. All healthcare professionals should be aware the temporal...