A5024249031- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Plant Reproductive Biology
- Organometallic Complex Synthesis and Catalysis
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- S100 Proteins and Annexins
- Plant Molecular Biology Research
- Crystallography and molecular interactions
- Protease and Inhibitor Mechanisms
- Plant Stress Responses and Tolerance
- Plant and Fungal Interactions Research
- Seed Germination and Physiology
- Nuts composition and effects
- Plant Pathogens and Resistance
- Legume Nitrogen Fixing Symbiosis
- Cancer Research and Treatments
- Lipid metabolism and biosynthesis
- Plant Genetic and Mutation Studies
- Synthesis and Reactivity of Heterocycles
- Plant Virus Research Studies
- Biomarkers in Disease Mechanisms
- Peptidase Inhibition and Analysis
Leitat Technological Center
2013-2022
FC Barcelona
2015-2020
Helix (United States)
2018-2020
Institute for Biomedicine
2018
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2012
Imperial College London
2012
University of Sheffield
2012
Institute of Agrifood Research and Technology
1998-2001
Centre d’Investigació i Desenvolupament
1996-2001
Institut Botànic de Barcelona
1998
The aim of this study was to investigate the effect postoperative peritoneal infection on proliferation, migration, and invasion capacities cancer cells lines in vitro after surgery for colorectal cancer.Anastomotic leakage is associated with higher rates recurrence cancer. However, mechanisms responsible are unknown. We hypothesized that infection-induced inflammatory response may enhance tumor progression features residual cells.Prospective matched cohort study. Patients undergoing...
S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis stimulating angiogenesis. We demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via RAGE receptor, in promoting cell migration increasing KDR expression MMP-9 activity. In vivo overexpression led to significant increase vascularization human melanoma xenograft M21 model. Conversely, when silencing shRNA technology, dramatic decrease...
Angiogenesis is a fundamental process to normal and abnormal tissue growth repair, which consists of recruiting endothelial cells toward an angiogenic stimulus. The subsequently proliferate differentiate form tubes capillary-like structures. Little known about the metabolic adaptation through such transformation. We studied changes cell activation by factors using human umbilical vein (HUVECs), [1,2- 13 C 2 ]-glucose mass isotopomer distribution analysis. metabolism HUVEC allows us trace...
Despite progresses in diagnosis and treatment, pancreatic cancer continues to have the worst prognosis of all solid malignant tumors. Recent evidences suggest that metastasis-promoting protein S100P stimulates tumor proliferation, survival, invasion metastasis progression through extracellular functions. Moreover, its expression is strongly correlated with poor patients several types although entire molecular mechanism responsible for diverse biological functions not fully understood. We...
The synthesis of the endo five-membered cyclo-ortho-palladated benzophenone imines [Pd{C6H4(Ph)C═NR}]2(μ-X)2 [1 (X = OAc), 2 Cl), a (R phenyl), b 1-naphthyl), c benzyl), d α-methylbenzyl)], and trans-N,P-[Pd{C6H4(Ph)C═NR}X(PPh3)] [3 4 α-methylbenzyl)] X-ray molecular structure 1a, 1c, 1d, 4a, 4b, 4c are reported. antitumor activity, DNA interaction, cathepsin B inhibition palladium compounds a–d were studied compared with those previously reported for e R H compound 4f analogous to 4e but...
We analyzed several genes that were strongly expressed in response to dehydration of almond (Prunus amygdalus (L.) Batsch) as a means identifying and determining the genetic basis mechanisms involved drought tolerance. The advantages using model system for studying tolerance woody species include its small diploid genome adaptation drought. used differential expression technique cDNA-AFLP (amplified restriction fragment polymorphism derived RNA fingerprinting) identify transcripts...
Synthesis and biological evaluation of 1-(1-naphthyl)ethylamine platinum derivatives are reported.
The cyclopalladation of a series symmetric diimines with the formula (RC6H4CH═NZ)2, where Z = CH2 or (CH2)2OCH2 and R p-Cl, p-OMe, p-NO2, o-Cl, is described. Optimal conditions to obtain dimetalated compounds were found be palladium(II) acetate, in toluene, at 60 °C reaction time 2–4 h. reactivity monodentate, bidentate, bis(monodentate) Lewis bases was also studied. cytotoxic activity some selected evaluated against panel adenocarcinoma cell lines (colon HCT116 breast MCF7 MDA-MB231)....
The members of the human regulators calcineurin (RCAN) protein family are endogenous (CN)-cytosolic nuclear factor activated T-cells (NFATc) pathway activation. This function is explained by presence a highly conserved calcipressin inhibitor (CIC) motif in RCAN proteins, which has been shown to compete with NFATc for binding CN and therefore able inhibit dephosphorylation activation CN. Very recently, emerging roles proteins transformation, tumor angiogenesis metastasis have described...