A5053016661- Dementia and Cognitive Impairment Research
- Edible Oils Quality and Analysis
- Neurological Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Behavioral Health and Interventions
- Alzheimer's disease research and treatments
- Antioxidant Activity and Oxidative Stress
- Cannabis and Cannabinoid Research
- Obesity, Physical Activity, Diet
- Environmental Education and Sustainability
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Cholesterol and Lipid Metabolism
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Advanced Glycation End Products research
- Sphingolipid Metabolism and Signaling
- Hops Chemistry and Applications
- Mobile Health and mHealth Applications
- Health, Environment, Cognitive Aging
- Pharmacogenetics and Drug Metabolism
Municipal Institute for Medical Research
2016-2025
Universitat Pompeu Fabra
2016-2024
Hospital Del Mar
2016-2024
Hospital del Mar Research Institute
2016-2024
Advanced Neural Dynamics (United States)
2023
Hospital de Clínicas
2022
Universitat Autònoma de Barcelona
2016
Instituto de Salud Carlos III
2016
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2016
Universidad de Montevideo
2012
Hydroxytyrosol and tyrosol are dietary phenolic compounds present in virgin olive oil wine. Both also endogenously synthesized our body as byproducts of dopamine tyramine metabolisms, respectively. Over the last decades, research into hydroxytyrosol has experienced an increasing interest due to role that these may play prevention certain pathologies (e.g. cardiovascular, metabolic, neurodegenerative diseases cancer). The translation promising vitro vivo biological effects from preclinical...
Beer is a fermented beverage with beneficial phenolic compounds and widely consumed worldwide. The current study aimed to describe the content of three families relevant biological activities: prenylated flavonoids (from hops), simple alcohols fermentation) alkylresorcinols cereals) in large sample beers (n = 45). analyzed were xanthohumol, isoxanthohumol, 6- 8-prenylnaringenin. total present beer ranged from 0.0 9.5 mg/L. tyrosol hydroxytyrosol, ranging 0.2 44.4 0.1 mg/L, respectively. Our...
Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of strongest dietary antioxidants, by CYP2A6 CYP2D6 polymorphic enzymes. We investigated in humans rate this bioconversion after beer red (RW) intake. In a single blind, randomized, crossover, controlled clinical trial (n = 20 healthy subjects), we evaluated TYR absorption biotransformation HT following dose (i) RW, (ii) Indian pale ale (IPA), (iii) blonde beer, (iv)...
Acylethanolamides are a family of endogenous lipid mediators that involved in physiological and behavioral processes associated with addiction. Recently, oleoylethanolamide (OEA) has been reported to reduce alcohol intake relapse rodents but the contribution OEA other acylethanolamides addiction humans is unknown. The present study aimed characterize plasma dependence. Seventy-nine abstinent alcohol-dependent subjects (27 women) recruited from outpatient treatment programs age-/sex-/body...
Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods plant origin. Its dietary consumption leads formation several phase I and II metabolites vivo, which represent largest amount ferulates circulation intestine comparison with FA itself. In this work, we evaluated their efficacy against proinflammatory effects induced by lipopolysaccharide (LPS) intestinal Caco-2 cell monolayers, as well mechanisms underlying protective action....
Well-designed effective interventions promoting sustainable diets are urgently needed to benefit both human and planetary health. This study evaluated the feasibility, acceptability, potential impact of a pilot blended digital intervention aimed at diets. We conducted series ABA n-of-1 trials with baseline, intervention, follow-up phases over course year, involving twelve participants. The included text messages, individualized online feedback sessions. Quantitative data on diet composition...
Subjects exhibiting subjective cognitive decline (SCD) are at an increased risk for mild impairment and dementia. Given the delay between exposure disease onset, SCD individuals increasingly considered a good target population cost-effective lifestyle-based Alzheimer's prevention trials.The PENSA study is randomized, double-blind, controlled clinical trial that aims to evaluate efficacy of personalized multimodal intervention in lifestyle (diet counseling, physical activity, training, social...
Abstract Background The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) N- acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved multiple neurological disorders metabolic processes. Hypothesizing that eCBs NAEs will be biomarkers a MedDiet intervention related to the response, we investigated this relationship according sex apolipoprotein E ( APOE)...
Protective mechanisms against drug-induced liver injury are actively being searched to identify new therapeutic targets. Among them, the anti-inflammatory N-acyl ethanolamide (NAE)-peroxisome proliferators activated receptor alpha (PPARα) system has gained much interest after identification of its protective role in steatohepatitis and fibrosis. An overdose paracetamol (APAP), a commonly used analgesic/antipyretic drug, causes hepatotoxicity, it is as model. In present study, we have...
Extra virgin olive oil (EVOO) and red wine (RW) are two basic elements that form part of the so-called Mediterranean diet. Both stand out because their high phenolic compound content potential related health benefits. The present study is focused on metabolic disposition resveratrol (RESV), tyrosol (TYR), hydroxytyrosol (HT) following consumption EVOO, RW, a combination both. In this study, 12 healthy volunteers consumed single dose 25 mL 150 both in crossover randomized clinical trial....
Protective mechanisms of the endogenous cannabinoid system against drug-induced liver injury (DILI) are actively being investigated regarding differential regulatory role CB1 and CB2 receptors in fibrogenesis inflammation.The 2-arachidonoylglycerol (2-AG)-related signalling enzymatic machinery, inflammatory/fibrogenic factors were a mouse model hepatotoxicity induced by acute repeated overdoses (750 mg·kg-1 ·day-1 ) paracetamol (acetaminophen), previously treated with selective (ACEA)...
Introduction The maintenance of endothelial barrier function is essential for vasal homeostasis and prevention cardiovascular diseases. Among the toxic stimuli involved in initiation atherosclerotic lesions, Gram negative lipopolysaccharide (LPS) has been reported to be able trigger dysfunction, through alteration permeability inflammatory response. Hydroxytyrosol (HT) tyrosol (Tyr), major phenolic compounds extra virgin olive oil (EVOO), as wells their circulating sulphated glucuronidated...
Background: Sustainable diets are healthy dietary patterns with low environmental impact, that economically fair and affordable. This study aimed to evaluate the feasibility, acceptability, potential impact of a pilot blended digital intervention at promoting behavior change towards sustainable diets. Methods: We conducted series ABA (A phase: 2-week baseline evaluation; B 22-week intervention; A 24-week post-intervention, follow-up) N-of-1 trials over year. Intervention involved (i) text...
The sudden changes (increase in capillary permeability, edema formation, vasodilation and hypotension) observed septic patients the measurements taken order to revert this situation make vancomycin concentrations difficult interpret. Therapeutic drug monitoring (TDM) of is routinely performed at steady state, target are peaks between 20 40 mg/l troughs 5-10 mg/l. Lately, continuous infusion (CIV) has been used as an alternative mode administration mainly critically ill with sepsis or shock....
Epidemiological studies have shown that consuming olive oil rich in phenolic bioactive compounds is associated with a lower risk of neurodegenerative diseases and better cognitive performance aged populations. Since oxidative stress common hallmark age-related decline, incorporating exogenous antioxidants could beneficial effects on brain aging. In this review, we firstly summarize critically discuss the current preclinical evidence potential neuroprotective mechanisms. Existing indicates...