A5066823962- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and biosynthesis
- Edible Oils Quality and Analysis
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Meat and Animal Product Quality
- Advanced Glycation End Products research
- Protein Hydrolysis and Bioactive Peptides
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Probiotics and Fermented Foods
- Aquaculture Nutrition and Growth
- Ginger and Zingiberaceae research
- Cancer, Lipids, and Metabolism
- Barrier Structure and Function Studies
- Garlic and Onion Studies
- Birth, Development, and Health
- Phytochemical Studies and Bioactivities
- Diet, Metabolism, and Disease
- Dietary Effects on Health
University of Cagliari
2013-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2001-2011
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2008
Twenty-three Lactobacillus strains of dairy origin were evaluated for some functional properties relevant to their use as probiotics. A preliminary subtractive screening based on the abilities inhibit growth microbial pathogens and hydrolyze conjugated bile salts was applied, six selected further characterization including survival under gastrointestinal environmental conditions, adhesion gut epithelial tissue, enzymatic activity, safety properties. All maintained elevated cell numbers...
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering epithelial layer thus contributing pathogenesis human inflammatory bowel diseases colon cancer. Extra virgin olive oil polyphenols possess antioxidant anti-inflammatory properties, concentrate lumen, where help preventing diseases. In study we evaluated ability...
Conjugated linoleic acid (CLA) is known to provide certain health benefits in experimental animal models. The major CLA isomer food c 9,t11-CLA. A primary objective of this study was investigate the uptake 9,t11-CLA and its downstream metabolites into various lipid fractions liver rats fed either a high or low diet (containing 0.1 0.8 g CLA/100 diet, respectively). As expected, levels all conjugated diene (CD) fatty acids (CD 18:2 + CD 18:3 20:3 20:4) were elevated about 8-fold group....
Abstract There is increasing evidence that individual isomers of conjugated linoleic acid (CLA) may have unique biological or biochemical effects. A primary objective this study was to determine whether there might be differences in the anticancer activity 9,11-CLA and 10,12-CLA. This achieved by evaluating reduction premalignant lesions carcinomas mammary gland rats had been treated with a single dose methylnitrosourea given 0.5% either highly purified CLA isomer diet. Our results showed...
Abstract The objective of this report was to determine whether vaccenic acid (t11-18:1) is converted efficiently conjugated linoleic (c9,t11-18:2, CLA) in rats via the Δ2-desaturase reaction and, if so, could substitute for CLA as an anticancer agent. In Study 1, were fed 1%, 2%, or 3% their diet, and tissue levels metabolites determined liver mammary gland. general, concentrations increased proportionately with increase intake, at least up 2% dose level. Beyond dose, there clearly a...
The aim of this study was to investigate the ability sulfate metabolites hydroxytyrosol (HT) and tyrosol (TYR) act as antioxidants counteracting pro-oxidant effect oxidized cholesterol in intestinal cells. For purpose, we synthesized HT TYR using a chemical methodology examined their antioxidant activity Caco-2 monolayers comparison with parent compounds. Exposure led ROS production, oxidative damage, indicated by MDA increase, decrease reduced glutathione concentration an enhancement...
Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods plant origin. Its dietary consumption leads formation several phase I and II metabolites vivo, which represent largest amount ferulates circulation intestine comparison with FA itself. In this work, we evaluated their efficacy against proinflammatory effects induced by lipopolysaccharide (LPS) intestinal Caco-2 cell monolayers, as well mechanisms underlying protective action....
Abstract In this work the molecular fatty components of Pecorino Sardo Protected Designation Origin (PS PDO) cheese were characterized through an exhaustive investigation 1 H‐ and 13 C‐NMR spectra extracted lipids. Several acids (FA), such as long chain saturated, oleic, linoleic, linolenic, butyric, capric, caprylic, caproic, trans vaccenic, conjugated linoleic acid ( cis 9, 11–18:2), caproleic (9–10:1) unambiguously detected. The positional isomery some acyl groups in glycerol backbone...
n-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance the inflammatory response. We investigated changes to HUFA score of healthy adults, induced by different types amounts conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for periods time, compared dietary fish oil (FO) pills (500 mg, each containing 100 mg eicosapentaenoic docosahexaenoic acids—EPA+DHA) or α-linolenic (ALA)-rich linseed (4 g, 2 g ALA). A significant...