A5033225743- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Edible Oils Quality and Analysis
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Plant biochemistry and biosynthesis
- Cholesterol and Lipid Metabolism
- Meat and Animal Product Quality
- Wnt/β-catenin signaling in development and cancer
- Phytochemistry and Biological Activities
- RNA Research and Splicing
- Cancer-related gene regulation
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Aquaculture Nutrition and Growth
- Biochemical Analysis and Sensing Techniques
- Fatty Acid Research and Health
- Phase Equilibria and Thermodynamics
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Nuts composition and effects
- Fermentation and Sensory Analysis
- Olfactory and Sensory Function Studies
- Bioactive natural compounds
- RNA modifications and cancer
University of Cagliari
2016-2025
Toscana Life Sciences
2024-2025
Gloucestershire Hospitals NHS Foundation Trust
2024
SUNY Downstate Health Sciences University
2021
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2002-2017
Siena Biotech (Italy)
2010-2016
Queen's Medical Centre
2012-2015
Nottingham University Hospitals NHS Trust
2012-2015
In-Q-Tel
2015
University of Nottingham
2015
Glioblastoma multiforme (GBM) is among the most deadly cancers. A number of studies suggest that a fraction tumor cells with stem cell features (Glioma Stem-like Cells, GSC) might be responsible for GBM recurrence and aggressiveness. GSC similarly to normal neural cells, can form neurospheres (NS) in vitro, seem mirror genetic original better than glioma growing adherently presence serum. Using cDNA microarray analysis we identified relevant genes biology are differentially expressed...
This study investigated chemical composition, cytotoxicity in normal and cancer cells, antimicrobial antioxidant activity of the essential oil (EO) isolated by hydrodistillation from discarded leaves lemon (Citrus limon) plants cultivated Sardinia (Italy). The volatile composition leaf EO (LLEO) was analyzed with gas chromatography-mass spectrometry combined flame ionization detection (GC/MS GC/FID). most abundant component LLEO limonene (260.7 mg/mL), followed geranial (102.6 mg/mL) neral...
The cytotoxic and apoptotic properties of four bioactive natural compounds, the prenylated α-pyronephloroglucinol heterodimer arzanol (ARZ), methoxylated flavones eupatilin (EUP) xanthomicrol (XAN), sesquiterpene zerumbone (ZER), were compared in SH-SY5Y human neuroblastoma cells to assess their potential as neuroblastoma-specific therapeutics. EUP, XAN, ZER (2.5–100 μM) exerted marked significant cytotoxicity (MTT assay) morphological changes after 24 h incubation, following order XAN >...
Hot peppers are a good source of dietary antioxidants, encompassing, apart from widespread compounds (flavonoids, phenolic acids, carotenoids, vitamin A, ascorbic acid, tocopherols), also specific constituents such as the pungent capsaicinoids (capsaicin, dihydrocapsaicin, and related analogues). We have shown that capsinoids show remarkable antioxidant activity. These benign analogues capsaicin could protect linoleic acid against free radical attack in simple vitro systems, inhibiting both...
Objectives To assess the role of serum amylase and lipase in diagnosis acute pancreatitis. Secondary aims were to perform a cost analysis these enzyme assays patients admitted surgical admissions unit. Design Cohort study. Setting care. Participants Patients with pancreatitis unit from January December 2010 included Methods Data collated demographics, laboratory results aetiology. The measuring single assay was £0.69 both £0.99. Results Of 151 included, 117 had gallstones (n=51) as most...
Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized water by mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- folate-conjugated PF108 so that the possess targeting, therapeutic, imaging properties. Nanoparticles investigated DLS, cryo-TEM, SAXS to confirm their structural...
The stability of extra virgin olive oils is mainly due to their relatively low fatty acids unsaturation and the antioxidant activity some unsaponifiable components. We studied α-tocopherol in oil its natural state, using new simple oxidizing conditions "thin layer" "bulk phase". Oxidation time course was monitored at 37 °C or 75 °C. A storage test also performed. Two parameters were evaluated: depletion formation PUFA hydroperoxides, measured as conjugated dienes (CD) peroxide value. value...
Abstract: Isolation of volatile and fixed oils from nutmeg have been obtained by supercritical fractioned extraction with carbon dioxide. Extraction experiments were carried out at pressures 90 250 bar temperature 40 °C. The step performed produced a fraction mainly formed myristicin (32.8%), sabinene (16.1%), α‐pinene (9.8%), β‐pinene (9.4%), β‐phellandrene (4.9%), safrole (4.1%) terpinen‐4‐ol (3.6%). oil yield relative to this the process was 1.4% weight charge. last butter‐like material...
Analysis of living cells after staining with organelle-specific dyes shows that monoolein-based cubosome treatment induces accumulation lipid droplets (green) and mitochondrial (red) hyperpolarization.
Microfluidic mixing is recognized as a convenient method to produce liposomes for its scalability and reproducibility. Numerous studies have described the effect of process parameters such flow rate ratios total on size distribution vesicles. In this work, we focused our attention encapsulation efficiency liposomes, hypothesized that different amount residual organic solvent could affect retention lipophilic drug molecules within bilayer. further step, investigated how integrity loading were...
This study examined the supercritical fluid extraction of wheat germ oil. The effects pressure (200-300 bar at 40 degrees C) and time on oil quality/quantity were studied. A comparison was also made between relative qualities material obtained by SFE organic solvent extraction. extracts analyzed for alpha-tocopherol polyunsaturated fatty acid content. maximum yield about 9% with carbon dioxide 300 bar, while composition not remarkable affected either or method.
Isolation of volatile and fixed oils from dried berries Laurus nobilis L. Tunisia have been obtained by supercritical fractioned extraction with carbon dioxide. Extraction experiments were carried out at a temperature 40 degrees C pressures 90 250 bar. The step performed bar produced fraction mainly composed (E)-beta-ocimene (20.9%), 1,8-cineole (8.8%), alpha-pinene (8.0%), beta-longipinene (7.1%), linalool acetate (4.5%), cadinene (4.7%), beta-pinene (4.2%), alpha-terpinyl (3.8%)...
Bioavailability studies in animals and humans fed with extravirgin olive oil demonstrated that hydroxytyrosol tyrosol, the major simple phenolic compounds oil, are dose-dependently absorbed excreted. Once absorbed, they undergo extensive metabolism; tyrosol concentrate mainly kidney, where may exert an important role prevention of oxidative stress induced renal dysfunction. In this study we monitored ability to protect cells (LLC-PK1) following damage by H 2 O . Oxidative was evaluated...