A5032993442- Neurological disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Prion Diseases and Protein Misfolding
- Hemoglobinopathies and Related Disorders
- Autism Spectrum Disorder Research
- Dysphagia Assessment and Management
- Cardiac Structural Anomalies and Repair
- Epilepsy research and treatment
- Dementia and Cognitive Impairment Research
- Sphingolipid Metabolism and Signaling
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Microtubule and mitosis dynamics
- Meningioma and schwannoma management
- Multiple Sclerosis Research Studies
- Voice and Speech Disorders
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Cervical and Thoracic Myelopathy
- Glioma Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
AHEPA University Hospital
2015-2025
Aristotle University of Thessaloniki
2016-2025
The aim of this study is to propose a practical smartphone-based tool accurately assess upper limb tremor in Parkinson's disease (PD) patients. uses signals from the phone's accelerometer and gyroscope (as phone held or mounted on subject's hand) compute set metrics which can be used quantify patient's symptoms. In small-scale clinical with 25 PD patients 20 age-matched healthy volunteers, we combined our machine learning techniques correctly classify 82% 90% high compared similar studies....
The DEAD/DExD/H-box RNA helicases are a group of RNA-binding proteins involved in the metabolism mRNAs. They coordinate gene expression programs and play role cellular signaling, fate, survival. We describe case 36-year-old female with neuromuscular disease, sensorineural hearing loss, retinitis pigmentosa, primary ovarian insufficiency harboring heterozygous de novo missense pathogenic variant DEAH-box helicase 16 (DHX16) gene. This is first exhibiting high intellectual level highest...
Repulsive guidance molecule-a (RGMa) has emerged as a significant therapeutic target in variety of neurological disorders, including neurodegenerative diseases and acute conditions. This review comprehensively examines the multifaceted role RGMa central nervous system (CNS) pathologies such Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, multiple neuromyelitis optica spectrum disorder, spinal cord injury, stroke, vascular dementia, auditory neuropathy, epilepsy. The...
With an ever-growing number of technologically advanced methods for the diagnosis and quantification movement disorders, comes need to assess their accuracy see how they match up with widely used standard clinical assessment tools. This work compares quantitative measurements hand tremor in twenty-three Parkinson's disease patients, scores components Unified Disease Rating Scale (UPDRS), which is considered "gold standard" disease. Our were obtained using a smartphone-based platform,...
To investigate whether neurofilament light polypeptide (NfL) level in cerebrospinal fluid (CSF), currently a prognostic biomarker of neurodegeneration patients with multiple sclerosis (MS), may be potential cognitive dysfunction MS.This observational case-control study included MS. CSF levels NfL were determined using enzyme-linked immunosorbent assay. Cognitive function was measured the Brief International Assessment for MS (BICAMS) battery and Paced Auditory Serial Addition Test (PASAT3),...
Recent advances in mobile phone technology have placed an impressive array of sensing and communication equipment at the hands ever-growing number people. One areas which can potentially be transformed by availability what is essentially a cheap, ubiquitous networked sensor, that remote diagnosis movement disorders, such as Parkinson's disease. This work describes smartphone-based method for detecting quantifying hand tremor associated with disorders using signals from accelerometer...
Extrapyramidal symptoms are observed in frontotemporal dementia (FTD). <sup>123</sup>I-FP-CIT (DaT scan) single photon emission computed tomography (SPECT) can detect loss of presynaptic dopamine transporters the striatum. We aimed to evaluate dopaminergic status striatum patients with FTD using DaT scan. Seven (age range 65–76 years), who fulfilled Neary criteria and whom diagnosis was confirmed by hexamethylpropyleneamine oxime SPECT, were included study. The severity...
Clear cell renal carcinomas (ccRCCs) constitute the most common carcinomas, characterized by a relatively aggressive clinical course. Thus, scientific research is targeting towards identification of immunohistochemical and molecular markers that could be useful regarding diagnosis, appropriate therapy prediction prognosis. In present study we assessed correlated expression caspase-8, phosphorylated p38 mitogen-activated protein kinase (p-p38) bcl-2 with histopathological features outcome 27...
Background:Alzheimer's Disease (AD) and Vascular Dementia (VaD) are the most common causes of dementia in older people. Both diseases appear to have similar clinical symptoms, such as deficits attention executive function, but specific cognitive domains affected. Current cohort studies shown a close relationship between αβ deposits age-related macular degeneration (Johnson et al., 2002; Ratnayaka 2015). Additionally, link thinning retinal nerve fiber (RNFL) AD patients has been described,...
Spinal muscular atrophy (SMA) is a hereditary neuromuscular disorder, typically caused by survival motor neuron 1 (SMN1) gene deletion in chromosome 5q resulting loss of SMN protein. SMA type progresses rapidly leading to increased mortality usually before the age 2 years. Nusinersen, first approved disease-modifying treatment for all 5q-SMA types and ages, an antisense oligonucleotide administered intrathecally via repeated lumbar punctures. However, adult patients present with severe...